How to Commission, Operate and Maintain a Large Future Accelerator Complex from Far Remote

A study on future large accelerators [1] has considered a facility, which is designed, built and operated by a worldwide collaboration of equal partner institutions, and which is remote from most of these institutions. The full range of operation was considered including commi-ssioning, machine development, maintenance, trouble shooting and repair. Experience from existing accele-rators confirms that most of these activities are already performed 'remotely'. The large high-energy physics ex-periments and astronomy projects, already involve inter-national collaborations of distant institutions. Based on this experience, the prospects for a machine operated remotely from far sites are encouraging. Experts from each laboratory would remain at their home institution but continue to participate in the operation of the machine after construction. Experts are required to be on site only during initial commissioning and for par-ticularly difficult problems. Repairs require an on-site non-expert maintenance crew. Most of the interventions can be made without an expert and many of the rest resolved with remote assistance. There appears to be no technical obstacle to controlling an accelerator from a distance. The major challenge is to solve the complex management and communication problems.Comment: ICALEPCS 2001 abstract ID No. FRBI001 invited talk submitting author F. Willeke 5 pages, 1 figur

Beam diagnostics for charge and position measurements in ELI-NP GBS

The advanced source of Gamma-ray photons to be built in Bucharest (Romania), as part of the ELI-NP European Research Infrastructure, will generate photons by Compton back-scattering in the collision between a multi-bunch electron beam and a high intensity recirculated laser pulse. An S-Band photoinjector and the following C-band Linac at a maximum energy of 720MeV, under construction by an European consortium (EurogammaS) led by INFN, will operate at 100Hz repetition rate with trains of 32 electron bunches, separated by 16ns and a 250pC nominal charge. The different BPMs and current transformers used to measure transverse beam position and charge along the LINAC are described. Design criteria, production status and bench test results of the charge and position pickups are reported in the paper, together with the related data acquisition systems

Haematological and biochemical findings in pregnant, postfoaling and lactating jennies

The aims of this study were to: 1) verify if significant changes occur in hematological and biochemical parameters in jennies during the last two months of pregnancy and the first two months of lactation, and 2) determine any differences with equine species. Materials and methods. Hematological and biochemical parameters were evaluated in jennies every 15 days during late pregnancy, parturition, and early lactation. The Kolmogorov-Smirnov test, ANOVA for repeated measurements and Tukey’s multiple comparison test as post hoc were applied. The significance level was set at p<0.05. Results. Statistical analysis showed differences related to time for RBC and HCT, WBC, PLT, total proteins (TP), blood urea, triglycerides and total cholesterol concentrations, AST, GGT, CK activities, sodium (Na) and potassium (K). Discussion and conclusions. RBC and HCT were higher in late pregnancy than at foaling and during lactation. The relative anaemia might be due to increased water ingestion due to fluid losses. The WBC count was higher at foaling than during late pregnancy and lactation. This could be related to the release of cortisol and catecholamine during delivery. The PLT trend showed lower values from delivery to the first two months of lactation compared to late gestation. Blood urea increased near parturition, and then remained constant during delivery and lactation, which might be due to the high-energy demand at the beginning of lactation. Triglycerides and total cholesterol showed a decrease from delivery through the lactation period. Thus jennies seem to have a similar metabolism of fats to ponies and draft horse mares, characterized by a greater fat content and mobilization than light breed horses. AST activity decreased at parturition and early lactation, probably due to a predominance of anabolic over catabolic processes during pregnancy. GGT activity was lower at delivery and during lactation than at late gestation. This could be due to a physiological load on the liver in the perinatal period. GGT activity was always higher than in mares, but within the normal range for adult donkeys. CK decreased near delivery, then was constant from parturition through the first two months of lactation. Na decreased during lactation, probably due to an increased renal retention mediated by aldosterone release during pregnancy. K showed the same trend as Na, and concentrations are in line with the species. The higher K during pregnancy may be due to reabsorption by the gut. TP decreased more during the post-partum period and lactation than in the gestational period

Identification and characterization of citrus concave gum-associated virus infecting citrus and apple trees by serological, molecular and high-throughput sequencing approaches

Citrus concave gum-associated virus (CCGaV) is a negative-stranded RNA virus, first reported a few years ago in citrus trees from Italy. It has been reported in apple trees in the USA and in Brazil, suggesting a wider host range and geographic distribution. Here, an anti-CCGaV polyclonal antiserum to specifically detect the virus has been developed and used in a standard double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) that has been validated as a sensitive and reliable method to detect this virus both in citrus and apple trees. In contrast, when the same antiserum was used in direct tissue-blot immunoassay, CCGaV was efficiently detected in citrus but not in apple. Using this antiserum, the first apple trees infected by CCGaV were identified in Italy and the presence of CCGaV in several apple cultivars in southern Italy was confirmed by field surveys. High-throughput sequencing (HTS) allowed for the assembling of the complete genome of one CCGaV Italian apple isolate (CE-c3). Phylogenetic analysis of Italian CCGaV isolates from apple and citrus and those available in the database showed close relationships between the isolates from the same genus (Citrus or Malus), regardless their geographical origin. This finding was further confirmed by the identification of amino acid signatures specific of isolates infecting citrus or apple hosts. Analysis of HTS reads also revealed that the CE-c3 Italian apple tree, besides CCGaV, was simultaneously infected by several viruses and one viroid, including apple rubbery wood virus 2 which is reported for the first time in Italy. The complete or almost complete genomic sequences of the coinfecting agents were determined

ITER LHe Plants Parallel Operation

AbstractThe ITER Cryogenic System includes three identical liquid helium (LHe) plants, with a total average cooling capacity equivalent to 75kW at 4.5K.The LHe plants provide the 4.5 K cooling power to the magnets and cryopumps. They are designed to operate in parallel and to handle heavy load variations.In this proceedingwe will describe the presentstatusof the ITER LHe plants with emphasis on i) the project schedule, ii) the plantscharacteristics/layout and iii) the basic principles and control strategies for a stable operation of the three LHe plants in parallel

Identification, full-length genome sequencing, and field survey of citrus vein enation virus in Italy

Citrus vein enation virus (CVEV) was described in Spain and then it has been reported in several citrus growing areas of Asia, America and Australia. Here, the occurrence of CVEV in Italy has been documented for the first time. The full genome sequence of a CVEV Italian isolate (14Q) was determined by high-throughput sequencing and the presence of the virus was confirmed by RT-PCR and graft-transmission to indicator plants, from which the virus was recovered six-months post-inoculation. Phylogenetic analysis based on the full-length genome of CVEV isolates from different countries showed that they are phylogenetically related to each other based on their geographic origin, rather than on their host and that the Italian isolate is more closely related to the Spanish isolate than to the other ones. A field survey revealed the presence of CVEV in some areas of Campania region (southern Italy), prevalently infecting lemon trees. In the frame of this survey, kumquat was identified for the first time as a host of CVEV. No symptoms were observed in the field so far. The infection of asymptomatic hosts and the transmission by aphid species present in Italy increase the risk that the virus could further spread

Supplementary light differently influences physico-chemical parameters and antioxidant compounds of tomato fruits hybrids

One of the challenges for agriculture in the coming years will be producing more food avoiding reducing the nutritional values of fruits and vegetables, sources of nutraceutical com-pounds. It has been demonstrated that light-emitting diodes (LEDs) used as a supplementary light (SL) technology improve tomato yield in Mediterranean greenhouses, but few data have been re-ported about SL effects on fruit physio-chemical parameters. In this study, three tomato hybrid (F1) cultivars were grown for year-round production in a commercial semi-closed glasshouse in Southern Italy: red cherry type (“Sorentyno”), red plum type (“Solarino”), and yellow plum type (“Maggino”). From 120 to 243 days after transplant (DAT), Red/White/Blue LEDs were used as SL. The fruits harvested 180 DAT were analyzed and those obtained under LEDs had 3% more dry weight, 15% more total soluble solids, and 16% higher titratable acidity than fruits grown only under natural light. Generally, the antioxidant activity and the mineral profile of the fruits were not negatively influenced by SL. Lycopene content was unchanged and vitamin C content of “Sorentyno” even increased by 15% under LEDs. Overall, LEDs used as SL technology could be one of the tools used by agriculture in Mediterranean basin to produce more food maintaining high quality production

Experimental Setup and Measuring System to Study SolitaryWave Interaction with Rigid Emergent Vegetation

The aim of this study is to present a peculiar experimental setup, designed to investigate the interaction between solitary waves and rigid emergent vegetation. Flow rate changes due to the opening and closing of a software-controlled electro-valve generate a solitary wave. The complexity of the problem required the combined use of different measurement systems of water level and velocity. Preliminary results of the experimental investigation, which allow us to point out the effect of the vegetation on the propagation of a solitary wave and the effectiveness of the measuring system, are also presented. In particular, water level and velocity field changes due to the interaction of the wave with rigid vegetation are investigated in detail

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Background: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives: To evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. Animals: Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs. Methods: Prospective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. Results: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P &lt;.001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P =.005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7-490 vs 24.6 pg/mL, range, 5.5-56.4; P =.003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P =.02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg/mL, range, 120.8-575.6 vs 448.7 pg/mL, range, 244.8-753; P =.03). Conclusions and Clinical Importance: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism