81 research outputs found
On-chip differential interference contrast microscopy using lensless digital holography.
We introduce the use of a birefringent crystal with lensless digital holography to create an on-chip differential interference contrast (DIC) microscope. Using an incoherent source with a large aperture, in-line holograms of micro-objects are created, which interact with a uniaxial crystal and an absorbing polarizer, encoding differential interference contrast information of the objects on the chip. Despite the fact that a unit fringe magnification and an incoherent source with a large aperture have been used, holographic digital processing of such holograms rapidly recovers the differential phase contrast image of the specimen over a large field-of-view of approximately 24 mm(2)
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Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings.
The recent revolution in digital technologies and information processing methods present important opportunities to transform the way optical imaging is performed, particularly toward improving the throughput of microscopes while at the same time reducing their relative cost and complexity. Lensfree computational microscopy is rapidly emerging toward this end, and by discarding lenses and other bulky optical components of conventional imaging systems, and relying on digital computation instead, it can achieve both reflection and transmission mode microscopy over a large field-of-view within compact, cost-effective and mechanically robust architectures. Such high throughput and miniaturized imaging devices can provide a complementary toolset for telemedicine applications and point-of-care diagnostics by facilitating complex and critical tasks such as cytometry and microscopic analysis of e.g., blood smears, Pap tests and tissue samples. In this article, the basics of these lensfree microscopy modalities will be reviewed, and their clinically relevant applications will be discussed
The potential role of scar mapping in assessing of paroxysmal atrial fibrillation recurrence after cryoballoon application
Cryoballoon ablation for atrial fibrillation (AF) has become a frequently used therapy after failure of at least one antiarrhythmic drug. The main target of AF ablation has been durable pulmonary vein isolation. However, it is unclear if ablation strategies need to be modified after recurrence. Herein, we presented a female patient undergoing successful pulmonary vein re-connection ablation after left atrial scar mapping. In electroanatomical mapping, gray area shows intense scar tissue. Gray, red, and purple areas indicate atrial potentials <0.5 mV, 0.5–1.5 mV, and >1.5 mV, respectively. Please note that there is a non-scar area in the bottom of right inferior pulmonary vein (arrow)
Coronary artery fistula: Review of 54 cases from single center experience
Background: Demographic and clinical characteristics and angiographic findings of Turkish
patients with coronary artery fistula have been investigated in this study and diagnostic tests
and treatment methods used in these patients have also been evaluated in detail.
Methods: We have examined the cardiac catheterization laboratory database retrospectively
between March 2006 and July 2010. Among 49,567 patients, we have noted 60 patients
diagnosed as coronary artery fistula. After coronary angiographic images were evaluated by
two invasive cardiologists, 54 patients who had clear evidence of vessel of origin and drainage
were included in the study.
Results: A total of 54 (0.1%) patients with coronary artery fistula were noted. Mean age was
56.7 ± 10.7 years; 42 out of 54 patients had accompanying cardiac disorders. Patients’
complaints were directly associated with the presence of the fistula. Chest pain was the admission
symptom in all of the patients with isolated coronary artery fistula. Six patients had
coexistent congenital anomalies. Myocardial infarction with ST segment elevation occurred in
11 of the patients. In contrast to the previous reports, the most common artery of origin of the
fistula was left anterior descending artery (50.8%) and pulmonary artery was found to be the
most frequent region of the fistula drainage by 53.7%.
Conclusions: Our findings suggest that large fistulas originating from the proximal segments
of coronary arteries may increase the likelihood of atherosclerosis and myocardial
infarction even in asymptomatic patients with no evidence of ischemia in noninvasive tests
and no dilatation of cardiac chambers, and should therefore be closed
Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
Evaluation of nutritional status in pediatric intensive care unit patients: the results of a multicenter, prospective study in Turkey
IntroductionMalnutrition is defined as a pathological condition arising from deficient or imbalanced intake of nutritional elements. Factors such as increasing metabolic demands during the disease course in the hospitalized patients and inadequate calorie intake increase the risk of malnutrition. The aim of the present study is to evaluate nutritional status of patients admitted to pediatric intensive care units (PICU) in Turkey, examine the effect of nutrition on the treatment process and draw attention to the need for regulating nutritional support of patients while continuing existing therapies.Material and MethodIn this prospective multicenter study, the data was collected over a period of one month from PICUs participating in the PICU Nutrition Study Group in Turkey. Anthropometric data of the patients, calorie intake, 90-day mortality, need for mechanical ventilation, length of hospital stay and length of stay in intensive care unit were recorded and the relationship between these parameters was examined.ResultsOf the 614 patients included in the study, malnutrition was detected in 45.4% of the patients. Enteral feeding was initiated in 40.6% (n = 249) of the patients at day one upon admission to the intensive care unit. In the first 48 h, 86.82% (n = 533) of the patients achieved the target calorie intake, and 81.65% (n = 307) of the 376 patients remaining in the intensive care unit achieved the target calorie intake at the end of one week. The risk of mortality decreased with increasing upper mid-arm circumference and triceps skin fold thickness Z-score (OR = 0.871/0.894; p = 0.027/0.024). The risk of mortality was 2.723 times higher in patients who did not achieve the target calorie intake at first 48 h (p = 0.006) and the risk was 3.829 times higher in patients who did not achieve the target calorie intake at the end of one week (p = 0.001). The risk of mortality decreased with increasing triceps skin fold thickness Z-score (OR = 0.894; p = 0.024).ConclusionTimely and appropriate nutritional support in critically ill patients favorably affects the clinical course. The results of the present study suggest that mortality rate is higher in patients who fail to achieve the target calorie intake at first 48 h and day seven of admission to the intensive care unit. The risk of mortality decreases with increasing triceps skin fold thickness Z-score
Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin
Blockchain as a general-purpose technology: patentometric evidence of science, technologies and actors
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