4,933 research outputs found

    Multiple Regimes in Cross-Region Growth Regressions with Spatial Dependence: A Parametric and a Semi-parametric Approach

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    This paper studies the distribution dynamics of development across European regions over the period 1975-2000. Regional development is measured in terms of both per capita GDP (Y/P) and its components: labour productivity and employment ratio (that in turn can be decomposed in terms of activity and unemployment rate). The Core/Periphery pattern in the European Union is firstly investigated and a comparative analysis in terms of income, productivity, employment and unemployment rates of the two partitions is carried out. Moreover, for each variable as well as for each partition, a nonparametric beta convergence analysis is applied. Synthetically, the results confirm the lack of regional convergence in per capita incomes, the presence of a negative quasi-linear relationship between growth rates and initial levels of labour productivity and a U-shaped relationship between growth rates and initial levels of unemployment rates. As it is well known, however, b-convergence analysis does not allow any test of multiple equilibria, such as “emerging twin peaks”, in the growth process. Equilibrium multiplicity can be properly assessed by using nonparametric techniques of analysis of the cross-regional distribution. In particular, a way to quantify the intra-distribution dynamics is the multivariate kernel, which estimates the joint density of regional income, productivity and (un)employment distribution at time t0 and t0+t. The results of this analysis suggest that over the period considered the regional growth pattern in Europe has followed a polarisation process rather than a convergence path. This appears particularly true in the case of per capita incomes and unemployment rates. Finally, in order to “explain” polarisation, conditional multivariate kernels are estimated. In particular, the role of spatial contiguity and regional sectoral specialisation is investigated.

    Effects of Increasing Doses of Intracoronary Adenosine on the Assessment of Fractional Flow Reserve

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    ObjectivesThe purpose of this study was to investigate the effects of increasing dose of intracoronary adenosine on fractional flow reserve (FFR) measurement.BackgroundsFFR is a validated method for the assessment of the severity of coronary artery stenosis. It is based on the change in the pressure gradient across the stenosis after the achievement of maximal hyperemia of the coronary microcirculation that may be obtained by either intracoronary bolus or intravenous infusion of adenosine. No study has explored so far the effects of very high doses of intracoronary adenosine on FFR.MethodsFFR was assessed in 46 patients with 50 intermediate lesions during cardiac catheterization by pressure-recording guidewire (PrimeWire, Volcano, San Diego, California). FFR was calculated as the ratio of the distal coronary pressure to the aortic pressure at hyperemia. Increasing doses of adenosine were administrated (60, 120, 180, 360, and 720 μg) as intracoronary boluses. Exclusion criteria were: 1) allergy to adenosine; 2) baseline bradycardia (heart rate <50 beats/min); 3) hypotension (blood pressure <90 mm Hg); and 4) refusal to provide signed informed consent.ResultsHigh doses of intracoronary adenosine were well tolerated, with no major side effects. Increasing doses up to 720 μg progressively decreased FFR values and increased the percentage of patients showing an FFR <0.75. Among angiographic parameters, both percent stenosis and lesion length were independently associated with lower FFR values.ConclusionsThis study shows that high doses of intracoronary adenosine (up to 720 μg) increased the sensitivity of FFR in the detection of hemodynamically relevant coronary stenoses. Furthermore, lesion length and stenosis severity were independent angiographic determinants of FFR

    Buenas prácticas para el desarrollo web

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    Una guía de buenas prácticas a tener en cuenta para el desarrollo seguro de aplicaciones web.Práctica profesional supervisada de la carrera Analista en Tecnologías de la Información y la Comunicación. Tutor: Matías Murieta.Facultad de Informátic

    Numerically stable formulations of convective terms for turbulent compressible flows

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    A systematic analysis of the discrete conservation properties of non-dissipative, central-difference approximations of the compressible Navier-Stokes equations is reported. A general triple splitting of the nonlinear convective terms is considered, and energy-preserving formulations are fully characterized by deriving a two-parameter family of split forms. Previously developed formulations reported in literature are shown to be particular members of this family; novel splittings are introduced and discussed as well. Furthermore, the conservation properties yielded by different choices for the energy equation (i.e. total and internal energy, entropy) are analyzed thoroughly. It is shown that additional preserved quantities can be obtained through a suitable adaptive selection of the split form within the derived family. Local conservation of primary invariants, which is a fundamental property to build high-fidelity shock-capturing methods, is also discussed in the paper. Numerical tests performed for the Taylor-Green Vortex at zero viscosity fully confirm the theoretical findings, and show that a careful choice of both the splitting and the energy formulation can provide remarkably robust and accurate results

    The Sunyaev-Zeldovich MITO Project

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    Compton scattering of the cosmic microwave background radiation by electrons in the hot gas in clusters of galaxies - the Sunyaev-Zeldovich effect - has long been recognized as a uniquely important feature, rich in cosmological and astrophysical information. We briefly describe the effect, and emphasize the need for detailed S-Z and X-ray measurements of nearby clusters in order to use the effect as a precise cosmological probe. This is the goal of the MITO project, whose first stage consisted of observations of the S-Z effect in the Coma cluster. We report the results of these observations.Comment: To appear in Proceedings of `Understanding our Universe at the close of XXth century', School held Apr 25 - May 6 2000, Cargese, 16 pages LaTeX, 2 figures ps (using elsart.sty & elsart.cls), text minor revisio

    Numerical Simulations of Vorticity Banding of Emulsions in Shear Flows

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    Multiphase shear flows often show banded structures that affect the global behavior of complex fluids e.g. in microdevices. Here we investigate numerically the banding of emulsions, i.e. the formation of regions of high and low volume fraction, alternated in the vorticity direction and aligned with the flow (shear bands). These bands are associated with a decrease of the effective viscosity of the system. To understand the mechanism of banding experimentally observed we have performed interface resolved simulations of the two-fluid system. The experiments were perfomed starting with a random distribution of droplets which, under the applied shear, evolves in time resulting in a phase separation. To numerically reproduce this process, the banded structures are initialized in a narrow channel confined by two walls moving in opposite direction. We find that the initial banded distribution is stable when droplets are free to merge and unstable when coalescence is prevented. In this case, additionally, the effective viscosity of the system increases, resembling the rheological behavior of suspensions of deformable particles. Droplets coalescence, on the other hand, allows emulsions to reduce the total surface of the system and hence the energy dissipation associated to the deformation, which in turn reduces the effective viscosity
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