Modeling of immune life history and body growth: the role of antigen burden

In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune system. The treatise is based on the assumption of linear dependence of antigen load from basal metabolic rate, which, in turn, depends on body mass following the allometric relationship – 3/4 power scaling law (Kleiber, 1932; West, Brown, 2005). Energy cost of antigen burden, i.e. the energy needed to produce and maintain immune cells plus the energy loss due to infectious diseases, is estimated and used as a measure of the immune system effectiveness. The dependence of optimal resource allocation from the parameters of antigen load is studied.

Cytoenzymochemical study of polymorpho-nucleic leukocytes and their role in mechanism of natural resistence to plague

Revealed has been the dependence of the infection process flow heaviness versus the content of the biologically active proteins in the polymorpho-nucleic leukocytes and the activity of the enzymes. The participation of some proteins and enzymes in the realization of the natural resistance to the plague has been determined. The materials of the thesis have been the base for the methodical recommendations and the authorized Certificate 'Method of Isolation of Kation Proteins in Neutrophyl granulocytes of Blood'. The tests on estimation of the natural immunity state of the noon sandworts and mountain gophersAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

DEVELOPMENT OF METHOD OF LASER ATOMIC-FLUORESCENT SPECTROMETRY FOR DIRECT DETECTION OF FEMTOGRAM CONTENTS OF HEAVY METALS

The analytical properties of the resonant lines and two-frequency excitation circuits have been investigated. The methods for detection of Bi and Cd with detection limit 2,5 and 3,5 femtograms have been developed. The reconstructrion of the Cd content in the Antarctic atmosphere for 155000 years has been made. The content of Bi in the Greenland snow and ice has been detected firstly. The two-beam computer-aided laser fluorescent spectroscopy has been createdAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Energy cost of infection burden: An approach to understanding the dynamics of host-pathogen interactions

Abstract A mathematical model of long-term immune defense against infection was used to estimate the energy involved in the principal processes of immune resistance during periods of health and infection. From these values, an optimal level of energy was determined for immune response depending on infection burden. The present findings suggest that weak but prevalent pathogens lead to latent or chronic infection, whereas more virulent but less prevalent pathogens result in acute infection. This energy-based approach offers insight into the mechanisms of immune system adaptation leading to the development of chronic infectious diseases and immune deficiencies. Published by Elsevier Ltd

Large artificial ferromagnetic dot arrays for the critical current enhancement in superconducting YBa2Cu3O7-δthin films

© 2020 IOP Publishing Ltd. In order to enhance and/or control critical current density (J c) in superconducting YBa2Cu3O7-δ (YBCO) thin films, different arrays of 3 µm large ferromagnetic (iron) dots with differing configurations and shapes have been deposited on top of high-quality YBCO thin films post-buffered with a layer of CeO2. Some tremendous J c enhancement of up to nearly 100% have been obtained at high temperatures and low fields. However, the J c performance is strongly dependent on the array configurations, shape and amount of ferromagnetic iron involved. We show that it is possible to enhance J c at high or low magnetic field ranges. The results are clearly different to similar non magnetic array structures used to previously manipulate J c in YBCO films, which proves the magnetic origin of the changes in J c we observed. The enhancement is likely due to the flux localization and magnetic pinning effects, rather than magnetic shielding alone, which is effective at relatively low fields only. The results also suggest that the observed J c changes depend on rather minor variations in initial pinning and corresponding J c levels of the films. At the same time a common trend for all of the various investigated magnetic arrays could not be established due to explained factors

Origin of magnetic flux-jumps in Nb films subject to mechanical vibrations and corresponding magnetic perturbations

In this paper the origin of flux-jumps in Nb thin films is established during magnetization measurements using a vibrating sample magnetometer (VSM). Magnetization measurements of the flux avalanche activity show its strong dependence on frequency and amplitude of VSM vibration. In particular, under certain conditions the vibrations induce a transition from a stable superconducting critical state to an undercritical state, accompanied by the 20-fold drop in the magnetic moment. These features allow the elucidation of the origin of the flux-jumps. In contrast to the commonly assumed thermomagnetic instabilities to be responsible for the flux-jumps in Nb films, our results provide solid support for an alternative explanation being due to criticality-built instability well represented by a sandpile. Considering properties of the flux-flow during a flux avalanche regime allows us to estimate nonuniformity of a magnetic field in a VSM sample space developed as a result of vibrations