The history of radioiodine therapy beginnings

This report contains historical review of radioiodine therapy invention and clinical implementation for the treatment of patients with diffuse toxic goiter and differentiated thyroid cancer. In 1923 Henry Plummer has strongly recommended to prescribe stable iodine in patients with Grave’s diseases after surgery in order to prevent thyrotoxic storm. Radioactive isotopes of iodine for the first time were obtained by Enrico Fermi in 1934 in laboratory. Clinical implementation of radioiodine was started in 40th years of past century. In 1940 experimentally have been shown that thyroid gland with Grave’s disease accumulated as much as 80% of radioiodine administered activity. Saul Hertz was the first physician who used radioactive iodine in January, 1941 with purpose to treat diffuse toxic goiter patients. Samuel Seidlin was first who used radioiodine in March, 1943 to treat patient with functioned differentiated thyroid cancer metastases. In Russia radioiodine treatment of patients started since 1982 in Medical Radiological Research Centre (former Institute of Medical Radiology), Obninsk

Synthesis and investigation of the thermal proper- ties of [Co(N H-3)(6)] [Co(C2O4)(3)]center dot 3H(2)O and [Ir(NH3)(6)][Ir(C2O4)(3)]

The complexes [Co (NH3)(6)][Ir (C2O4)(3)] and [Ir(NH3)(6)][Co (C2O4)(3)center dot H2O have previously been synthesized and their thermal properties studied. The [Ir(NH3)(6)][Ir(C2O4)(3)] and [Co(NH3)(6)][Co(C2O4)(3)]center dot 3H(2)O complexes considered here are the end members in a series of possible isostructural solid solutions based on the complex salts in the Co-Ir system. Their crystal structures and thermal properties are described in detail, including temperature-dependent in situ X-ray diffraction. During the thermolysis of these compounds, layered metal nanoparticles are formed. Close attention is paid to the details of the [Co(NH3)(6)][Ir(C2O4)(3)] synthesis. It has been shown that the formation of this complex salt is temperature dependent; upon heating, a new phase of the K-3[Co(NH3)(6)][Ir(C2O4)(3)](2)center dot 6H(2)O salt is formed, which incorporates the initial iridium compound into the crystal structure of the double complex salt. The target [Co(NH3)(6)][Ir(C2O4)(3)] product is obtained if the synthesis is carried out at room temperature

Formation of Catalytically Active Nanoparticles under Thermolysis of Silver Chloroplatinate(II) and Chloroplatinate(IV)

The thermal behaviour of Ag2[PtCl4] and Ag2[PtCl6] complex salts in inert and reducing atmospheres has been studied. The thermolysis of compounds in a helium atmosphere is shown to occur in two stages. At the first stage, the complexes decompose in the temperature range of 350–500 °C with the formation of platinum and silver chloride and the release of chlorine gas. At the second stage, silver chloride is sublimated in the temperature range of 700–900 °C, while metallic platinum remains in the solid phase. In contrast to the thermolysis of Ag2[PtCl6], the thermal decomposition of Ag2[PtCl4] at 350 °C is accompanied by significant heat release, which is associated with disproportionation of the initial salt to Ag2[PtCl6], silver chloride, and platinum metal. It is confirmed by DSC measurements, DFT calculations of a suggested reaction, and XRD. The thermolysis of Ag2[PtCl4] and Ag2[PtCl6] compounds is shown to occur in a hydrogen atmosphere in two poorly separable steps. The compounds are decomposed within 170–350 °C, and silver and platinum are reduced to a metallic state, while a metastable single-phase solid solution of Ag0.67Pt0.33 is formed. The catalytic activity of the resulting nanoalloy Ag0.67Pt0.33 is studied in the reaction of CO total (TOX) and preferential (PROX) oxidation. Ag0.67Pt0.33 enhanced Pt nano-powder activity in CO TOX, but was not selective in CO PROX

Precision low-dose brachytherapy of prostate cancer under PSMA-receptor molecular visualization

Brachytherapy with implantation of micro sources based on isotope 125I is a preferred treatment for localized prostate cancer without signs of germination of the gland capsule and in the absence of signs of metastases (stage cT1-T23aN0M0). Structural imaging methods (ultrasound, computed tomography, and magnetic resonance imaging) do not have high specificity in the differential diagnosis of prostate cancer. Hybrid technologies of radiation imaging (single-photon emission computed tomography/computed tomography, positron emission tomography/computed tomography, and positron emission tomography/magnetic resonance imaging) combine the advantages of high sensitivity of cross-sectional structural imaging methods (computed tomography and magnetic resonance imaging) and high specificity of molecular imaging methods (single-photon emission computed tomography and positron emission tomography) with tumorotropic radiopharmaceuticals. In this original clinical study, based on seven observations of localized prostate cancer (Gleason 6–7), it was shown that the precision of low-dose brachytherapy using 125I micro sources of localized prostate carcinomas, along with targeted biopsy, can be increased using hybrid methods of PSMA-receptor molecular imaging (single-photon emission computed tomography/ computed tomography, positron emission tomography/ computed tomography). The single-photon emission computed tomography/ computed tomography method is more accessible than positron emission tomography/ computed tomography. Moreover, when coupled with cold kits (HYNIC-PSMA), it allows research within any radioisotope diagnostics laboratory equipped with single-photon emission computed tomography/ computed tomography. The innovative technology of PSMA-navigation biopsy and brachytherapy, under the control of hybrid molecular imaging, can be used in primary and recurrent cases of localized prostate cancer, increases the accuracy and reduces the traumatic nature of procedures, and increases the medical and economic efficiency of low-dose brachytherapy with 125I micro sources. Further research is needed to improve the technology and evaluate its long-term results

USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective

Ubiquitin-specific protease 7 (USP7) regulates the stability of a plethora of intracellular proteins involved in the suppression of anti-tumor immune responses and its overexpression is associated with poor survival in many cancers. USP7 impairs the balance of the p53/MDM2 axis resulting in the proteasomal degradation of the p53 tumor suppressor, a process that can be reversed by small-molecule inhibitors of USP7. USP7 was shown to regulate the anti-tumor immune responses in several cases. Its inhibition impedes the function of regulatory T cells, promotes polarization of tumor-associated macrophages, and reduces programmed death-ligand 1 (PD-L1) expression in tumor cells. The efficacy of small-molecule USP7 inhibitors was demonstrated in vivo. The synergistic effect of combining USP7 inhibition with cancer immunotherapy is a promising therapeutic approach, though its clinical efficacy is yet to be proven. In this review, we focus on the recent developments in understanding the intrinsic role of USP7, its interplay with other molecular pathways, and the therapeutic potential of targeting USP7 functions

Polynuclear Hydroxido-Bridged Complexes of Platinum(IV) with Terminal Nitrato Ligands

For the first time the polynuclear hydroxido-bridged platinum­(IV) nitrato complexes with nuclearity higher than two were isolated from nitric acid solutions of [Pt­(H₂O)₂(OH)₄] and crystallized as supramolecular compounds of macrocyclic cavitands cucurbit­[<i>n</i>]­uril (CB­[<i>n</i>], <i>n</i> = 6,8) and 18-crown-6 ether: [Pt₄(μ₃-OH)₂­(μ₂-OH)₄­(NO₃)₁₀]·CB­[6]·25H₂O (<b>I</b>), [Pt₆(μ₃-OH)₄­(μ₂-OH)₆­(NO₃)₁₂]­(NO₃)₂·CB­[8]·50H₂O (<b>II</b>), and [H₃O⊂18-crown-6]₂­[Pt₂(μ₂-OH)₂(NO₃)₈]­[Pt₄(μ₃-OH)₂­(μ₂-OH)₄(NO₃)₁₀] (<b>III</b>). The isolation of the compounds in the single crystalline state allows the determination of the structure of the tetranuclear and hexanuclear complexes [Pt₄(μ₃-OH)₂­(μ₂-OH)₄(NO₃)₁₀] and [Pt₆(μ₃-OH)₄­(μ₂-OH)₆(NO₃)₁₂]²⁺, which have been previously unknown in the solid state. Stability of Pt_<i>x</i>(OH)_<i>y</i> cores of the polynuclear nitrato complexes toward alkaline hydrolysis was verified by ¹⁹⁵Pt NMR spectroscopy. Analysis of ¹⁹⁵Pt NMR spectra of the compound <b>III</b> reveals that addition of every Pt­(μ-OH)₂Pt ring results in ∼260 ppm downfield shift relative to the mononuclear form, which allows the prediction of signal positions for complexes of higher nuclearity

WSES project on decision support systems based on artificial neural networks in emergency surgery

The article is a scoping review of the literature on the use of decision support systems based on artificial neural networks in emergency surgery. The authors present modern literature data on the effectiveness of artificial neural networks for predicting, diagnosing and treating abdominal emergency conditions: acute appendicitis, acute pancreatitis, acute cholecystitis, perforated gastric or duodenal ulcer, acute intestinal obstruction, and strangulated hernia. The intelligent systems developed at present allow a surgeon in an emergency setting, not only to check his own diagnostic and prognostic assumptions, but also to use artificial intelligence in complex urgent clinical cases. The authors summarize the main limitations for the implementation of artificial neural networks in surgery and medicine in general. These limitations are the lack of transparency in the decision-making process; insufficient quality educational medical data; lack of qualified personnel; high cost of projects; and the complexity of secure storage of medical information data. The development and implementation of decision support systems based on artificial neural networks is a promising direction for improving the forecasting, diagnosis and treatment of emergency surgical diseases and their complications.Peer reviewe

USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective

5539-555

Pd-Ceria/CNMs Composites as Catalysts for CO and CH₄ Oxidation

The application of composite materials as catalysts for the oxidation of CO and other toxic compounds is a promising approach for air purification. In this work, the composites comprising palladium and ceria components supported on multiwall carbon nanotubes, carbon nanofibers and Sibunit were studied in the reactions of CO and CH4 oxidation. The instrumental methods showed that the defective sites of carbon nanomaterials (CNMs) successfully stabilize the deposited components in a highly-dispersed state: PdO and CeO2 nanoparticles, subnanosized PdOx and PdxCe1−xO2−δ clusters with an amorphous structure, as well as single Pd and Ce atoms, are formed. It was shown that the reactant activation process occurs on palladium species with the participation of oxygen from the ceria lattice. The presence of interblock contacts between PdO and CeO2 nanoparticles has an important effect on oxygen transfer, which consequently affects the catalytic activity. The morphological features of the CNMs, as well as the defect structure, have a strong influence on the particle size and mutual stabilization of the deposited PdO and CeO2 components. The optimal combination of highly dispersed PdOx and PdxCe1−xO2−δ species, as well as PdO nanoparticles in the CNTs-based catalyst, makes it highly effective in both studied oxidation reactions

Pd-Ce-Ox/MWCNTs and Pt-Ce-Ox/MWCNTs Composite Materials: Morphology, Microstructure, and Catalytic Properties

The composite nanomaterials based on noble metals, reducible oxides, and nanostructured carbon are considered to be perspective catalysts for many useful reactions. In the present work, multi-walled carbon nanotubes (MWCNTs) were used for the preparation of Pd-Ce-Ox/MWCNTs and Pt-Ce-Ox/MWCNTs catalysts comprising the active components (6 wt%Pd, 6 wt%Pt, 20 wt%CeO2) as highly dispersed nanoparticles, clusters, and single atoms. The application of X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM) provided analysis of the samples&rsquo; morphology and structure at the atomic level. For Pd-Ce-Ox/MWCNTs samples, the formation of PdO nanoparticles with an average crystallite size of ~8 nm was shown. Pt-Ce-Ox/MWCNTs catalysts comprised single Pt2+ ions and PtOx clusters less than 1 nm. A comparison of the catalytic properties of the samples showed higher activity of Pd-based catalysts in CO and CH4 oxidation reactions in a low-temperature range (T50 = 100 &deg;C and T50 = 295 &deg;C, respectively). However, oxidative pretreatment of the samples resulted in a remarkable enhancement of CO oxidation activity of Pt-Ce-Ox/MWCNTs catalyst at T &lt; 20 &deg;C (33% of CO conversion at T = 0 &deg;C), while no changes were detected for the Pd-Ce-Ox/MWCNTs sample. The revealed catalytic effect was discussed in terms of the capability of the Pt-Ce-Ox/MWCNTs system to form unique PtOx clusters providing high catalytic activity in low-temperature CO oxidation