Galactic Cosmic Rays - Clouds Effect and Bifurcation Model of the Earth Global Climate. Part 2. Comparison of Theory with Experiment

The solution of energy-balance model of the Earth global climate and the EPICA Dome C and Vostok experimental data of the Earth surface palaeotemperature evolution over past 420 and 740 kyr are compared. In the framework of proposed bifurcation model (i) the possible sharp warmings of the Dansgaard-Oeschger type during the last glacial period due to stochastic resonance is theoretically argued; (ii) the concept of climatic sensitivity of water in the atmosphere, whose temperature instability has the form of so-called hysteresis loop, is proposed, and based of this concept the time series of global ice volume over the past 1000 kyr, which is in good agreement with the time series of delta O-18 concentration in the sea sediments, is obtained; (iii) the so-called "CO2 doubling" problem is discussedComment: 19 pages, 4 figure

Transformation of the French external cultural policy concept at the turn of the century

The variety of conceptual aspects of the Frances's external cultural policy is considered in the article through adjustments introduced to it by different governments which staggered each other since 1980s. The modern concept of the French cultural diplomacy was a result of a long historic evolution in the framework of the traditional action of its governors aimed at protection of cultural identity and national interests of their country. From its genesis in the Middle Ages in the form of voluntary acts by its Monarchs and further by Republican Presidents this very concept was never translated into a basic programmatic document. It happened only in 1983 within specific historical circumstances in a form of a doctrinal paper entitled "External cultural project of France" elaborated and approved by the government of socialists. Since that time, conventionally speaking, the doctrine of the external cultural action of France could be divided in three stock ideas: cultural "shining", cultural exception and cultural diversity which alternated each other

Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study

Erythrocytes (RBCs) loaded with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALD) can metabolize plasma ethanol and acetaldehyde but with low efficiency. We investigated the rate-limiting factors in ethanol oxidation by these enzymes loaded into RBCs. Mathematical modeling and in vitro experiments on human RBCs loaded simultaneously with ADH and ALD (by hypoosmotic dialysis) were performed. The simulation showed that the rate of nicotinamide-adenine dinucleotide (NAD+) generation in RBC glycolysis, but not the activities of the loaded enzymes, is the rate-limiting step in external ethanol oxidation. The rate of oxidation could be increased if RBCs are supplemented by NAD+ and pyruvate. Our experimental data verified this theoretical conclusion. RBCs loaded with the complete system of ADH, ALD, NAD+, and pyruvate metabolized ethanol 20–40 times faster than reported in previous studies. The one-step procedure of hypoosmotic dialysis is the optimal method to encapsulate ADH and ALD in RBCs after cell recovery, encapsulation yield, osmotic resistance, and RBC-indexes. Consequently, transfusion of the RBCs loaded with the complete metabolic system, including ADH, ALD, pyruvate, and NAD+ in the patients with alcohol intoxication, may be a promising method for rapid detoxification of blood alcohol based on metabolism

Synthesis and Structure of Nido-Carboranyl Azide and Its “Click” Reactions

Novel zwitter-ionic nido-carboranyl azide 9-N3(CH2)3Me2N-nido-7,8-C2B9H11 was prepared by the reaction of 9-Cl(CH2)3Me2N-nido-7,8-C2B9H11 with NaN3. The solid-state molecular structure of nido-carboranyl azide was determined by single-crystal X-ray diffraction. 9-N3(CH2)3Me2N-nido-7,8-C2B9H11 was used for the copper(I)-catalyzed azide-alkyne cycloaddition with phenylacetylene, alkynyl-3β-cholesterol and cobalt/iron bis(dicarbollide) terminal alkynes to form the target 1,2,3-triazoles. The nido-carborane-cholesterol conjugate 9-3β-Chol-O(CH2)C-CH-N3(CH2)3Me2N-nido-7,8-C2B9H11 with charge-compensated group in a linker can be used as a precursor for preparation of liposomes for Boron Neutron Capture Therapy (BNCT). A series of novel zwitter-ionic boron-enriched cluster compounds bearing a 1,2,3-triazol-metallacarborane-carborane conjugated system was synthesized. Prepared conjugates contain a large amount of boron atom in the biomolecule and potentially can be used for BNCT

Traveling Wave Reactor and Condition of Existence of Nuclear Burning Soliton-Like Wave in Neutron-Multiplying Media

Physical fundamentals of traveling wave reactor are considered. We show that the condition of existence of nuclear burning soliton-like wave in a neutron-multiplying medium is determined in general by two conditions. The first condition (necessary) is determined by relationship between the equilibrium concentration and critical concentration of active (fissionable) isotope that is a consequence of the Bohr–Sommerfeld quantization condition. The second condition (sufficient) is set by the so-called Wigner quantum statistics, or more accurately, by a statistics of the Gaussian simplectic ensembles with respect to the parameter that describes the squared width of burning wave front of nuclear fuel active component