Hydrogen generation performance of waste aluminum alloy chips and powders

WOS: 000570291400001The objective of this work is to compare and evaluate hydrogen generation performance of 1050, 6013, and 7075 series commercial aluminum machining chips and powders obtained from mechanical milling of the chips. Prior to mechanical milling 20 wt.% NaCl was added to aluminum chips to activate aluminum. NaCl salt also functioned as a process control agent and prevented excessive cold welding of aluminum particles during intense plastic deformation applied by ball milling. Morphology of chips and powders was analyzed by scanning electron microscopy. Hydrogen generation experiments were performed by using distilled water and 1 M NaOH solution at 70 degrees C. the effect of temperature on the hydrogen production performance of aluminum alloys was also investigated in the range of 30-70 degrees C. Mechanically milled powders gave higher hydrogen generation yield compared to the chips. Severe cold working by mechanical milling accelerated the corrosion and increased the hydrogen production performance of the powders. Hydrogen production efficiency of milled powders in NaOH solution was approximately 3.5-7 times higher than milled powders in distilled water. Hydrogen yield of aluminum alloys increased with increasing alloy content and the highest values were obtained from Al 7075 powders in NaOH solution. It was also verified that the hydrogen yield increases with increasing reaction temperature

Mechanical properties of Mg-based materials fabricated by mechanical milling and spark plasma sintering

###EgeUn###In this work, magnesium powders of different grain sizes were synthesized by mechanical milling for periods ranging from 0.5 to 30 h. Subsequent to milling, powders were consolidated by spark plasma sintering at 550 celcius for 10 min. Before and after sintering, microstructural changes were investigated by analytical methods including X-ray diffraction (XRD), X-ray spectrometer, optical and electron microscopy. Analyses showed that nanocrystalline sizes were achieved by mechanical milling for milling times exceeding 5 h. Additionally, it was recognized that grain growth occurred during sintering, but to a limited extent. Mechanical test results displayed reasonable improvements in both compressive yield strength and hardness values with increasing milling times up to 5 h, where these reached their maximum values (245.5 MPa and 75.9 HV). The enhancement in these properties with increased milling time up to 5 h was attributed to both the extent of grain refinement and the formation of MgO together with incorporation of Fe particles, originating from the milling process, into the matrix. On the other hand, a substantial decrease in yield strength and hardness values in the samples milled in excess of 5 h were recorded, which in turn was related to the accompanying decline in bulk density of the samples. Microstructural analysis of the deformed samples revealed that grain size reduction suppressed twin formation, which elucidates the enhancement in ductility with decreasing grain size

Synthesis of Some Heterofunctionalized Penicillanic Acid Derivatives and Investigation of Their Biological Activities

Alpay Karaoglu, Sengul/0000-0003-1047-8350WOS: 000332331800006PubMed: 242934036-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage were obtained from 6-apa. the treatment of carbonylamino and carbonothioylamino compounds with 4-chlorophenacyl bromide or ethyl bromoacetate gave 6-bis{4-[1,3-thiazol(idinone)amino]benzoyl}amino derivatives of 6-apa. Benzyl derivatives were synthesized in several steps, starting with 4-aminobenzoyl chloride. the treatment of 4-{[3-benzyl-4-oxo-1,3-thia(oxa)zolidin-2-ylidene]amino}benzoyl chlorides with 6-apa in ethanolic solution produced the 6-[bis(4-{[3-benzyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoyl)amino] derivative of penicillanic acid, while the reaction of the same intermediates in DMF gave the mono-substituted amino derivative of 6-apa. the synthesized compounds were screened for their biological activities, and some of them were found to possess good to moderate antimicrobial activity. Moreover, some of the compounds displayed antiurease, anti--lactamase, and/or antilipase activities.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T427]The support provided by Scientific and Technological Research Council of Turkey (TUBITAK, Project no: 111T427) is gratefully acknowledged

Evaluation of hereditary/familial breast cancer patients with multigene targeted next generation sequencing panel and MLPA analysis in Turkey.

Breast cancer, a worldwide leading cause of cancer in women, may occur in familial cases. Germline mutations in BRCA1/2 genes are responsible for 15% of the familial cases. With the power of next generation sequencing (NGS) analysis, it is possible to analyze genes related to hereditary susceptibility to breast cancer and investigate the genetic etiology more thoroughly.In this study, we investigated 30 genes identified frequent pathogenic alleles in Turkish population. The study includes 495 unrelated individuals diagnosed with breast cancer who are selected for genetic testing according to NCCN criteria for hereditary breast cancer. All patients were analyzed by NGS for BRCA1/2 genes. Deletion/duplication investigation by Multiplex ligation-dependent probe amplification (MLPA) and massive sequencing of 30 breast cancer-related genes (Oncorisk Gene Panel) were performed in a stepwise manner. BRCA1/2 variants are the most frequent pathogenic variants which are found in 45 of 495 (9.1%) patients. Four previously unreported, novel, pathogenic variants of BRCA2 gene are identified. In four cases, exonic deletions of BRCA1/2 genes are determined and there is no duplication of these genes. NGS panel investigation involving other moderate-high risk genes contributed genetic diagnosis in an extra 39 out of 419 (9.3%) cases. Our study presents the cost effectiveness of the gene panel approach. We suggest that gene panels should be the first-tier genetic testing for hereditary breast cancer and MLPA analysis of BRCA1/2 genes should be investigated as a complementary method of NGS analysis. (c) 2022 Published by Elsevier Inc