SOFA score.

<p>Mean and SD of SOFA scores cumulatively observed for the entire population at the baseline, and then at 6, 12, 24 and 48 hrs after HCO-CVVHD initiation; and at 24 and 48 hrs after HCO-CVVHD discontinuation (Panel A). In Panel B, SOFA scores are shown for each subgroup (Survivors and non-Survivors). * Value statistically different to the baseline through statistical test for pairs data. † Value statistically different between groups through statistical test for unpaired data.</p

HCO-CVVHD treatment parameters across the groups.

<p>HCO-CVVHD treatment parameters across the groups.</p

Circulating levels of inflammatory mediators.

<p>Concentrations of mediators are expressed in a logarithmic scale.</p

Clinical and biochemical parameters for both the overall population and the Survivors and non-Survivors subgroups.

<p>Clinical and biochemical parameters for both the overall population and the Survivors and non-Survivors subgroups.</p

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p