1,508 research outputs found
Quantum dissipation due to the interaction with chaotic degrees-of-freedom and the correspondence principle
Both in atomic physics and in mesoscopic physics it is sometimes interesting
to consider the energy time-dependence of a parametrically-driven chaotic
system. We assume an Hamiltonian where . The
velocity is slow in the classical sense but not necessarily in the
quantum-mechanical sense. The crossover (in time) from ballistic to diffusive
energy-spreading is studied. The associated irreversible growth of the average
energy has the meaning of dissipation. It is found that a dimensionless
velocity determines the nature of the dynamics, and controls the route
towards quantal-classical correspondence (QCC). A perturbative regime and a
non-perturbative semiclassical regime are distinguished.Comment: 4 pages, clear presentation of the main poin
Scars of Invariant Manifolds in Interacting Chaotic Few-Body Systems
We present a novel extension of the concept of scars for the wave functions
of classically chaotic few-body systems of identical particles with rotation
and permutation symmetry. Generically there exist manifolds in classical phase
space which are invariant under the action of a common subgroup of these two
symmetries. Such manifolds are associated with highly symmetric configurations.
If sufficiently stable, the quantum motion on such manifolds displays a notable
enhancement of the revival in the autocorrelation function which is not
directly associated with individual periodic orbits. Rather, it indicates some
degree of localization around an invariant manifold which has collective
characteristics that should be experimentally observable.Comment: 4 pages, RevTeX, 4 PS/EPS-figures, uses psfig.sty, quantum
computation changed, to be published in Physical Review Letter
Empirical validation and proof of added value of MUSICA\u27s tropospheric δD remote sensing products
Computational Method for Phase Space Transport with Applications to Lobe Dynamics and Rate of Escape
Lobe dynamics and escape from a potential well are general frameworks
introduced to study phase space transport in chaotic dynamical systems. While
the former approach studies how regions of phase space are transported by
reducing the flow to a two-dimensional map, the latter approach studies the
phase space structures that lead to critical events by crossing periodic orbit
around saddles. Both of these frameworks require computation with curves
represented by millions of points-computing intersection points between these
curves and area bounded by the segments of these curves-for quantifying the
transport and escape rate. We present a theory for computing these intersection
points and the area bounded between the segments of these curves based on a
classification of the intersection points using equivalence class. We also
present an alternate theory for curves with nontransverse intersections and a
method to increase the density of points on the curves for locating the
intersection points accurately.The numerical implementation of the theory
presented herein is available as an open source software called Lober. We used
this package to demonstrate the application of the theory to lobe dynamics that
arises in fluid mechanics, and rate of escape from a potential well that arises
in ship dynamics.Comment: 33 pages, 17 figure
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Castrate-Resistant Prostate Cancer (CRPC) is characterized by persistent androgen receptor-driven tumor growth in the apparent absence of systemic androgens. Current evidence suggests that CRPC cells can produce their own androgens from endogenous sterol precursors that act in an intracrine manner to stimulate tumor growth. The mechanisms by which CRPC cells become steroidogenic during tumor progression are not well defined. Herein we describe a novel link between the elevated cholesterol phenotype of CRPC and the TERE1 tumor suppressor protein, a prenyltransferase that synthesizes vitamin K-2, which is a potent endogenous ligand for the SXR nuclear hormone receptor. We show that 50% of primary and metastatic prostate cancer specimens exhibit a loss of TERE1 expression and we establish a correlation between TERE1 expression and cholesterol in the LnCaP-C81 steroidogenic cell model of the CRPC. LnCaP-C81 cells also lack TERE1 protein, and show elevated cholesterol synthetic rates, higher steady state levels of cholesterol, and increased expression of enzymes in the de novo cholesterol biosynthetic pathways than the non-steroidogenic prostate cancer cells. C81 cells also show decreased expression of the SXR nuclear hormone receptor and a panel of directly regulated SXR target genes that govern cholesterol efflux and steroid catabolism. Thus, a combination of increased synthesis, along with decreased efflux and catabolism likely underlies the CRPC phenotype: SXR might coordinately regulate this phenotype. Moreover, TERE1 controls synthesis of vitamin K-2, which is a potent endogenous ligand for SXR activation, strongly suggesting a link between TERE1 levels, K-2 synthesis and SXR target gene regulation. We demonstrate that following ectopic TERE1 expression or induction of endogenous TERE1, the elevated cholesterol levels in C81 cells are reduced. Moreover, reconstitution of TERE1 expression in C81 cells reactivates SXR and switches on a suite of SXR target genes that coordinately promote both cholesterol efflux and androgen catabolism. Thus, loss of TERE1 during tumor progression reduces K-2 levels resulting in reduced transcription of SXR target genes. We propose that TERE1 controls the CPRC phenotype by regulating the endogenous levels of Vitamin K-2 and hence the transcriptional control of a suite of steroidogenic genes via the SXR receptor. These data implicate the TERE1 protein as a previously unrecognized link affecting cholesterol and androgen accumulation that could govern acquisition of the CRPC phenotype
Design and performance of a Collimated Beam Projector for telescope transmission measurement using a broadband light source
Type Ia supernovae are the most direct cosmological probe to study dark
energy in the recent Universe, for which the photometric calibration of
astronomical instruments remains one major source of systematic uncertainties.
To address this, recent advancements introduce Collimated Beam Projectors
(CBP), aiming to enhance calibration by precisely measuring a telescope's
throughput as a function of wavelength. This work describes the performance of
a prototype portable CBP. The experimental setup consists of a broadband Xenon
light source replacing a more customary but much more demanding high-power
laser source, coupled with a monochromator emitting light inside an integrating
sphere monitored with a photodiode and a spectrograph. Light is injected at the
focus of the CBP telescope projecting a collimated beam onto a solar cell whose
quantum efficiency has been obtained by comparison with a NIST-calibrated
photodiode. The throughput and signal-to-noise ratio achieved by comparing the
photocurrent signal in the CBP photodiode to the one in the solar cell are
computed. We prove that the prototype, in its current state of development, is
capable of achieving 1.2 per cent and 2.3 per cent precision on the integrated
g and r bands of the ZTF photometric filter system respectively, in a
reasonable amount of integration time. Central wavelength determination
accuracy is kept below {0.91} nm and {0.58} nm for g and r bands.
The expected photometric uncertainty caused by filter throughput measurement is
approximately 5 mmag on the zero-point magnitude. Several straightforward
improvement paths are discussed to upgrade the current setup.Comment: submitted to RAS Techniques & Instruments (RASTI
Computer-assisted liver graft steatosis assessment via learning-based texture analysis
Purpose: Fast and accurate graft hepatic steatosis (HS) assessment is of primary importance for lowering liver dysfunction risks after transplantation. Histopathological analysis of biopsied liver is the gold standard for assessing HS, despite being invasive and time consuming. Due to the short time availability between liver procurement and transplantation, surgeons perform HS assessment through clinical evaluation (medical history, blood tests) and liver texture visual analysis. Despite visual analysis being recognized as challenging in the clinical literature, few efforts have been invested to develop computer-assisted solutions for HS assessment. The objective of this paper is to investigate the automatic analysis of liver texture with machine learning algorithms to automate the HS assessment process and offer support for the surgeon decision process. Methods: Forty RGB images of forty different donors were analyzed. The images were captured with an RGB smartphone camera in the operating room (OR). Twenty images refer to livers that were accepted and 20 to discarded livers. Fifteen randomly selected liver patches were extracted from each image. Patch size was 100 × 100. This way, a balanced dataset of 600 patches was obtained. Intensity-based features (INT), histogram of local binary pattern (HLBPriu2), and gray-level co-occurrence matrix (FGLCM) were investigated. Blood-sample features (Blo) were included in the analysis, too. Supervised and semisupervised learning approaches were investigated for feature classification. The leave-one-patient-out cross-validation was performed to estimate the classification performance. Results: With the best-performing feature set (HLBPriu2+INT+Blo) and semisupervised learning, the achieved classification sensitivity, specificity, and accuracy were 95, 81, and 88%, respectively. Conclusions: This research represents the first attempt to use machine learning and automatic texture analysis of RGB images from ubiquitous smartphone cameras for the task of graft HS assessment. The results suggest that is a promising strategy to develop a fully automatic solution to assist surgeons in HS assessment inside the OR
Diffusion tensor imaging metrics associated with future disability in multiple sclerosis
The relationship between brain diffusion microstructural changes and disability in multiple sclerosis (MS) remains poorly understood. We aimed to explore the predictive value of microstructural properties in white (WM) and grey matter (GM), and identify areas associated with mid-term disability in MS patients. We studied 185 patients (71% female; 86% RRMS) with the Expanded Disability Status Scale (EDSS), timed 25-foot walk (T25FW), nine-hole peg test (9HPT), and Symbol Digit Modalities Test (SDMT) at two time-points. We used Lasso regression to analyse the predictive value of baseline WM fractional anisotropy and GM mean diffusivity, and to identify areas related to each outcome at 4.1 years follow-up. Motor performance was associated with WM (T25FW: RMSE = 0.524, R2 = 0.304; 9HPT dominant hand: RMSE = 0.662, R2 = 0.062; 9HPT non-dominant hand: RMSE = 0.649, R2 = 0.139), and SDMT with GM diffusion metrics (RMSE = 0.772, R2 = 0.186). Cingulum, longitudinal fasciculus, optic radiation, forceps minor and frontal aslant were the WM tracts most closely linked to motor dysfunction, and temporal and frontal cortex were relevant for cognition. Regional specificity related to clinical outcomes provide valuable information that can be used to develop more accurate predictive models that could improve therapeutic strategies
Living with AIDS in Uganda: a qualitative study of patients' and families' experiences following referral to hospice
Background:
Globally, the majority of people with HIV/AIDS live in sub-Saharan Africa. While the increasing availability of antiretroviral therapy is improving the outlook for many, its effects are yet to reach all of those in need and patients still present with advanced disease. This paper reports findings from qualitative interviews with patients living with AIDS and their caregivers who were receiving palliative care from Hospice Africa Uganda (HAU). We aimed to understand what motivated patients and their families to seek formal healthcare, whether there were any barriers to help- seeking and how the help and support provided to them by HAU was perceived.
Methods:
We invited patients with AIDS and their relatives who were newly referred to HAU to participate in qualitative interviews. Patients and carers were interviewed in their homes approximately four weeks after the patient’s enrolment at HAU. Interviews were translated, transcribed and analysed using narrative and thematic approaches.
Results:
Interviews were completed with 22 patients (10 women and 12 men) and 20 family caregivers, nominated by patients. Interviews revealed the extent of suffering patients endured and the strain that family caregivers experienced before help was sought or accessed. Patients reported a wide range of severe physical symptoms. Patients and their relatives reported worries about the disclosure of the AIDS diagnosis and fear of stigma. Profound poverty framed all accounts. Poverty and stigma were, depending on the patient and family situation, both motivators and barriers to help seeking behaviour. Hospice services were perceived to provide essential relief of pain and symptoms, as well as providing rehabilitative support and a sense of caring. The hospice was perceived relieve utter destitution, although it was unable to meet all the expectations that patients had.
Conclusion:
Hospice care was highly valued and perceived to effectively manage problems such as pain and other symptoms and to provide rehabilitation. Participants noted a strong sense of being “cared for”. However, poverty and a sense of stigma were widespread. Further research is needed to understand how poverty and stigma can be effectively managed in hospice care for patients for advanced AIDS and their families
Episodic photic zone euxinia in the northeastern Panthalassic Ocean during the end-Triassic extinction
Severe changes in ocean redox, nutrient cycling, and marine productivity accompanied most Phanerozoic mass extinctions. However, evidence for marine photic zone euxinia (PZE) as a globally important extinction mechanism for the end-Triassic extinction (ETE) is currently lacking. Fossil molecular (biomarker) and nitrogen isotopic records from a sedimentary sequence in western Canada provide the first conclusive evidence of PZE and disrupted biogeochemistry in neritic waters of the Panthalassic Ocean during the end Triassic. Increasing water-column stratification and deoxygenation across the ETE led to PZE in the Early Jurassic, paralleled by a perturbed nitrogen cycle and ecological turnovers among noncalcifying groups, including eukaryotic algae and prokaryotic plankton. If such conditions developed widely in the Panthalassic Ocean, PZE might have been a potent mechanism for the ETE.National Science Foundation (U.S.) (Grant EAR-1147402)Exobiology Program (U.S.) (Grants NNX09AM88G and NNA08CN84A)American Association of Petroleum Geologists (Grant-In-Aid)Mary-Hill and Bevan M. French Fund for Impact Geolog
- …