691 research outputs found
Potential Quality Indicators for Seriously Ill Home Care Clients: A Cross-Sectional Analysis Using Resident Assessment Instrument for Home Care (RAI-HC) Data for Ontario
Background Currently, there are no formalized measures for the quality of home based palliative care in Ontario. This study developed a set of potential quality indicators for seriously ill home care clients using a standardized assessment. Methods Secondary analysis of Resident Assessment Instrument for Home Care data for Ontario completed between 2006 and 2013 was used to develop quality indicators (QIs) thought to be relevant to the needs of older (65+) seriously ill clients. QIs were developed through a review of the literature and consultation with subject matter experts in palliative care. Serious illness was defined as a prognosis of less than 6 months to live or the presence of severe health instability. The rates of the QIs were stratified across Ontario’s geographic regions, and across four common life-limiting illnesses to observe variation. Results Within the sample, 14,312 clients were considered to be seriously ill and were more likely to experience negative health outcomes such as cognitive performance (OR = 2.77; 95% CI: 2.66–2.89) and pain (OR = 1.59; 95% CI: 1.53–1.64). Twenty subject matter experts were consulted and a list of seven QIs was developed. Indicators with the highest overall rates were prevalence of falls (50%) prevalence of daily pain (47%), and prevalence of caregiver distress (42%). The range in QI rates was largest across regions for prevalence of caregiver distress (21.5%), the prevalence of falls (16.6%), and the prevalence of social isolation (13.7%). Those with some form of dementia were most likely to have a caregiver that was distressed (52.6%) or to experience a fall (53.3%). Conclusion Home care clients in Ontario who are seriously ill are experiencing high rates of negative health outcomes, many of which are amenable to change. The RAI-HC can be a useful tool in identifying these clients in order to better understand their needs and abilities. These results contribute significantly to the process of creating and validating a standardized set of QIs that can be generated by organizations using the RAI-HC as part of normal clinical practice
Longitudinal Current Dissipation in Bose-glass Superconductors
A scaling theory of vortex motion in Bose glass superconductors with currents
parallel to the common direction of the magnetic field and columnar defects is
presented. Above the Bose-glass transition the longitudinal DC resistivity
vanishes much faster than the
corresponding transverse resistivity , thus {\it reversing} the usual anisotropy of electrical transport in
the normal state of layered superconductors. In the presence of a current at an angle with the common field and columnar defect axis, the
electric field angle approaches as .
Scaling also predicts the behavior of penetration depths for the AC currents as
, and implies a {\it jump discontinuity} at in
the superfluid density describing transport parallel to the columns.Comment: 5 pages, revte
Defect-unbinding and the Bose-glass transition in layered superconductors
The low-field Bose-glass transition temperature in heavy-ion irradiated
Bi_2Sr_2CaCu_2O_8+d increases progressively with increasing density of
irradiation-induced columnar defects, but saturates for densities in excess of
1.5 x10^9 cm^-2. The maximum Bose-glass temperature corresponds to that above
which diffusion of two-dimensional pancake vortices between different vortex
lines becomes possible, and above which the ``line-like'' character of vortices
is lost. We develop a description of the Bose-glass line that is in excellent
quantitative agreement with the experimental line obtained for widely different
values of track density and material parameters.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let
Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study
The relations were examined between colorectal cancer and cigarette smoking and alcohol consumption within the Singapore Chinese Health Study, a population-based, prospective cohort of 63 257 middle-aged and older Chinese men and women enrolled between 1993 and 1998, from whom baseline data on cigarette smoking and alcohol consumption were collected through in-person interviews. By 31 December 2004, 845 cohort participants had developed colorectal cancer (516 colon cancer, 329 rectal cancer). Compared with nondrinkers, subjects who drank seven or more alcoholic drinks per week had a statistically significant, 72% increase in risk of colorectal cancer hazard ratio (HR)=1.72; 95% confidence interval (CI)=1.33–2.22). Cigarette smoking was associated with an increased risk of rectal cancer only. Compared with nonsmokers, HRs (95% CIs) for rectal cancer were 1.43 (1.10–1.87) for light smokers and 2.64 (1.77–3.96) for heavy smokers. Our data indicate that cigarette smoking and alcohol use interact in the Chinese population in an additive manner in affecting risk of rectal cancer, thus suggesting that these two exposures may share a common etiologic pathway in rectal carcinogenesis
Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Effects of columnar disorder on flux-lattice melting in high-temperature superconductors
The effect of columnar pins on the flux-lines melting transition in
high-temperature superconductors is studied using Path Integral Monte Carlo
simulations. We highlight the similarities and differences in the effects of
columnar disorder on the melting transition in YBaCuO
(YBCO) and the highly anisotropic BiSrCaCuO (BSCCO) at
magnetic fields such that the mean separation between flux-lines is smaller
than the penetration length. For pure systems, a first order transition from a
flux-line solid to a liquid phase is seen as the temperature is increased. When
adding columnar defects to the system, the transition temperature is not
affected in both materials as long as the strength of an individual columnar
defect (expressed as a flux-line defect interaction) is less than a certain
threshold for a given density of randomly distributed columnar pins. This
threshold strength is lower for YBCO than for BSCCO. For higher strengths the
transition line is shifted for both materials towards higher temperatures, and
the sharp jump in energy, characteristic of a first order transition, gives way
to a smoother and gradual rise of the energy, characteristic of a second order
transition. Also, when columnar defects are present, the vortex solid phase is
replaced by a pinned Bose glass phase and this is manifested by a marked
decrease in translational order and orientational order as measured by the
appropriate structure factors. For BSCCO, we report an unusual rise of the
translational order and the hexatic order just before the melting transition.
No such rise is observed in YBCO.Comment: 32 pages, 13 figures, revte
Ethnic differences in effects of maternal prepregnancy and pregnancy adiposity on offspring size and adiposity
10.1210/jc.2015-1728The Journal of Clinical Endocrinology & Metabolism100103641–3650GUSTO (Growing up towards Healthy Outcomes
Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation
While nonmyeloablative peripheral blood stem cell transplantation (NST) has shown efficacy against several solid tumors, it is untested in nasopharyngeal cancer (NPC). In a phase II clinical trial, 21 patients with pretreated metastatic NPC underwent NST with sibling PBSC allografts, using CY conditioning, thymic irradiation and in vivo T-cell depletion with thymoglobulin. Stable lymphohematopoietic chimerism was achieved in most patients and prophylactic CYA was tapered at a median of day +30. Seven patients (33%) showed partial response and three (14%) achieved stable disease. Four patients were alive at 2 years and three showed prolonged disease control of 344, 525 and 550 days. With a median follow-up of 209 (4–1147) days, the median PFS was 100 days (95% confidence interval (CI), 66–128 days), and median OS was 209 days (95% CI, 128–236 days). Patients with chronic GVHD had better survival—median OS 426 days (95% CI, 194–NE days) vs 143 days (95% CI, 114–226 days) (P=0.010). Thus, NST may induce meaningful clinical responses in patients with advanced NPC
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