6 research outputs found
Hemostatic Swabs Containing Polydopamine-like Catecholamine Chitosan-Catechol for Normal and Coagulopathic Animal Models
All animal experiments for evaluating
drug efficacy or developing
medical devices are unavoidably accompanied by bleeding that result
in unreliable outcomes with large variations between individuals.
Herein, we developed hemostatic swabs prepared by a mussel-inspired
catecholamine polymer called chitosan-catechol, which was inspired
by the chemical composition of the well-known material-independent
coating material of polydopamine. The hemostatic ability of the swabs
resulted from the formation of self-sealing membranes by rapid intermolecular
interactions between whole blood proteins and the applied chitosan-catechol.
The blood protein/chitosan-catechol composite sealing membrane resulted
in dramatic decreases in bleeding for both normal and coagulopathic
models, such as diabetes
General-Purpose Ultrasound Neuromodulation System for Chronic, Closed-Loop Preclinical Studies in Freely Behaving Rodents
Transcranial focused ultrasound stimulation (tFUS) is an effective noninvasive treatment modality for brain disorders with high clinical potential. However, the therapeutic effects of ultrasound neuromodulation are not widely explored due to limitations in preclinical systems. The current preclinical studies are head-fixed, anesthesia-dependent, and acute, limiting clinical translatability. Here, this work reports a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. This work uses microelectromechanical systems (MEMS) technology to design and fabricate a small and lightweight transducer capable of artifact-free stimulation and simultaneous neural recording. Using the general-purpose system, it can be observed that state-dependent ultrasound neuromodulation of the prefrontal cortex increases rapid eye movement (REM) sleep and protects spatial working memory to REM sleep deprivation. The system will allow explorative studies in brain disease therapeutics and neuromodulation using ultrasound stimulation for widespread clinical adoption.11Nsciescopu
Effect of Metal-Precursor Stacking Order on Volume-Defect Formation in CZTSSe Thin Film: Formation Mechanism of Blisters and Nanopores
In this study, we investigated the effect of the stacking order of metal precursors on the formation of volume defects, such as blisters and nanopores, in CZTSSe thin-film solar cells. We fabricated CZTSSe thin films using three types of metal-precursor combinations, namely, Zn/Cu/Sn/Mo, Cu/Zn/Sn/Mo, and Sn/Cu/Zn/Mo, and studied the blister formation. The blister-formation mechanism was based on the delamination model, taking into consideration the compressive stress and adhesion properties. A compressive stress could be induced during the preferential formation of a ZnSSe shell. Under this stress, the adhesion between the ZnSSe film and the Mo substrate could be maintained by the surface tension of a metallic liquid phase with good wettability, or by the functioning of ZnSSe pillars as anchors, depending on the type of metal precursor used. Additionally, the nanopore formation near the back-contact side was found to be induced by the columnar microstructure of the metal precursor with the Cu/Zn/Mo stacking order and its dezincification. Based on the two volume-defect-formation mechanisms proposed herein, further development of volume-defect-formation suppression technology is expected to be made. © 2022 American Chemical Society.FALS
Quality of Community Life Among Rural Residents: An Integrated Model
Quality of community life, Community satisfaction, Community attachment, Housing satisfaction, Spillover effects,