281 research outputs found
Lung region segmentation based on computer tomographic images
The article is written for the benefit of hospitals in order to identify segments of the lungs and thereby help in the process of bisecting lungs according to their respective segments during surgery. Further research in this area can also help in identification of various abnormalities related to each segment and also identify abnormal walls of unhealthy lungs. Segmentation of the lungs has not been implemented in reality, as the lung, being an organ with dynamic chest volumes during respiratory cycles, makes it impossible to address changes during respiration unlike fixed structures like the brain. Further, abnormalities situated on the walls of lung segments, make it more difficult to address volume changes concerned with the lungs. The author of this paper has provided a more effective method to identify various lung segments by using various well known segmentation techniques combined together to identify moving lung image segments more effectively
Biological measurement beyond the quantum limit
Quantum noise places a fundamental limit on the per photon sensitivity
attainable in optical measurements. This limit is of particular importance in
biological measurements, where the optical power must be constrained to avoid
damage to the specimen. By using non-classically correlated light, we
demonstrated that the quantum limit can be surpassed in biological
measurements. Quantum enhanced microrheology was performed within yeast cells
by tracking naturally occurring lipid granules with sensitivity 2.4 dB beyond
the quantum noise limit. The viscoelastic properties of the cytoplasm could
thereby be determined with a 64% improved measurement rate. This demonstration
paves the way to apply quantum resources broadly in a biological context
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Abstract: Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were clinically suspected. In five patients we detect a primary immunodeficiency or enteropathy, with clinical consequences (XIAP, CYBA, SH2D1A, PCSK1). We also present a case study of a VEO-IBD patient with a mosaic de novo, pathogenic allele in CYBB. The mutation is present in ~70% of phagocytes and sufficient to result in defective bacterial handling but not life-threatening infections. Finally, we show that VEO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patients and 18,780 controls; P < 4 × 10−10), and replicate this finding in an independent cohort of VEO-IBD cases and controls (117 patients and 2,603 controls; P < 5 × 10−10). This discovery indicates that a polygenic component operates in VEO-IBD pathogenesis
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