THE CONCEPT OF COMPETITIVE OPPORTUNITIES DEVELOPMENT OF TRADE ORGANIZATION

Summary. The article gives the author’s vision of the concept of competitive opportunities development of the trade organization. To date, the theory of Applied Economics developed a wide array of concepts, which are the subject of a variety of economic phenomena and processes that accompany the operation of the organization, in accordance with the purpose of improving their prospects for the development of strategic development. Given that development of concepts accompanied by sufficiently convincing theoretical justification, not each of them is acceptable for use in economic practice. Many of the developers are limited staging concepts studied problems and arguments of its essential provisions, without bringing up the concept of applied instruments for its implementation. Furthermore, as shown by the results of acquaintance with the concepts of content close to the subject of our study, they overwhelmingly are not structured, presented logically interrelated provisions, but often not the logic of their development appears obvious. This, in our view, creates additional difficulties for the theoretical knowledge of the essence of new concepts and establishing differences of their content from existing, previously developed, and for the implementation of the concepts in economic practice. Therefore, the solution development concept of competitive potential trade organization, we consider it appropriate to precede the definition of the concept of structure, i.e. release of its structural units and the establishment of linkages between The author determines the necessity of its developing and structurizations of constituent blocks (target, methodological, criteria estimating, informative-analytical, tool-realizable) and gives their conten

PMU-based informational support of power system control tasks

Up-to-date wide area measurement systems (WAMS) based on phasor measurement units (PMU) appeared at the very end of the 20th century. Under present-day conditions, WAMS serve as the basis for information-measuring systems, which significantly improve power system control and operation. In practice, WAMS are mostly used for power system stability control and transient monitoring and visualization. This paper discusses the new opportunities for power system control quality improvement, resulting from PMU application for power system steady-state parameters' assessment. Firstly, better control is provided by online equivalent circuit parameters' identification using PMU measurement data and taking into account FACTS and other shunt and series compensation equipment. Secondly, the paper addresses the problems of "nodal" identification, which have taken on great importance recently due to the intensive development of small-scaled distributed generation. Based on PMU measurements of nodal voltages and incident transmission lines' electric currents, one can obtain online steady-state load characteristics, which can be used for dispatch control applications. Moreover, PMUs provide superaccelerated power flow calculations, which are of crucial importance for emergency automation, adjusted for prior operation. Such principles of emergency automation consist of the quick determination of control actions, aimed at power system stability maintenance in cases of any programmed faults' occurrence. It is known that such control is carried out by means of power flow calculations based on remote metering data. The proposed application and allocation of PMUs in the power system by means of combinatorial matrix transformation to triangle form give the possibility to perform accelerated node-voltage analysis without equivalent circuit simplification. All the calculations are verified using IEEE test networks. © 2014 WIT Press.International Journal of Safety and Security Engineering;International Journal of Sustainable Development and Planning;WIT Transactions on Ecology and the Environmen

Investigation of the infusion solutions of different qualitative composition influence on the dynamics of neuron specific enolase activity in patients with acute ischemic stroke

At the moment, the question remains insufficiently studied what kind of infusion fluids or their combination should be preferred in patients with acute ischemic stroke (AIS) to provide intensive care. Purpose. To investigate the dynamics of neuron-specific enolase (NSE) against the background of the iso-osmolar 0.9 % NaCl solution, colloid iso-osmolar fluid HES 130, colloid hyperosmolar fluid HAES-LX-5 % and hyperosmolar fluid mannitol application in AIS. Materials and methods. The study included 32 patients with AIS. As the studied solutions were used: colloid hyperosmolar HAES-LX-5 % (Gekoton), colloid iso-osmolar hydroxyethyl crystal 6 % 130/04 (HES 130), hyperosmolar mannitol 15 %, and iso-osmolar 0.9 % NaCl. The control group consisted of patients receiving only 0.9 % NaCl, the comparison groups – the patients receiving 0.9 % NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 %, or 0.9 % NaCl + mannitol. NSE activity was used as a marker of cerebral ischemia at the corresponding time (the 1st, 4th and 7th days). Results. An increase in NSE (P < 0.05) was observed in the 0.9 % NaCl group at the 7th day of stroke. A similar dynamics of NSE elevation was in the group with mannitol (P < 0.05), as well as in the control group. A 17.3 % decrease in the NSE activity was noted in the application of HES 130 at the end of observation relative to the 1st day. The NSE activity decreased by 34.6 % (P < 0.05) on the 7th day in comparison with the 1st day in the HAES-LX-5 % group and was significantly less than in the control group, groups of HES 130 and mannitol – on average 2.88 times and 30.3 %, 39.8 %, respectively. Conclusions. The use of 0.9 % NaCl or 0.9 % NaCl + mannitol within 7 days in patients with AIS in addition to basic therapy was accompanied by an increase in NSE. Infusion of 0.9 % NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 % was accompanied by a decrease in NSE activity at the 7th day of treatment, herewith the HAES-LX-5 % group showed the best dynamics of NSE activity decreasing (P < 0.05)

Assessment of infusion therapy impact on the dynamics of endothelin-1 in patients with acute ischemic stroke

The impact of infusion solutions on endothelial damage correction in acute ischemic stroke (AIS) remains an insufficiently studied. Purpose. To investigate the dynamics of endothelin-1 as one of the main markers of vasoconstriction and endothelial dysfunction (ED) with the use of 0.9 % NaCl, HES 130, HAES-LX-5 % and mannitol in patients with AIS. Materials and methods. The study included 32 patients with AIS. As the investigated solutions were used: colloid hyperosmolar HAES-LX-5 % (Gecoton), colloid isoosmolar hydroxyethylstarch 6% 130/04 (HES 130), hyperosmolar mannitol 15 %, isoosmolar 0.9 % NaCl. The control group consisted of patients who received only 0.9 % NaCl, comparison group patients received 0.9% NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 %, or 0.9 % NaCl + mannitol. The level of endothelin-1 (EN-1) served as a vasoconstriction marker of ED at a fixed time (days 1, 4 and 7). Results. Infusion therapy with only 0.9 % NaCl negatively affected the level of EN-1, since its level was 3.17 times increased on the 7th day of observation in comparison with the 4th day (P 0.05) at the end of observation in comparison with mannitol and 0.9 % NaCl groups, which showed a paradoxical increase in its level at the 7th day of infusion. Conclusions. The dynamics of EN-1 level as the main vasoconstrictor marker of ED were negative in the group of patients with 0.9 % NaCl and mannitol: its level was 3.17 and 3.48 times increased in the 0.9 % NaCl and mannitol groups (P < 0,05), respectively, on day 7 compared to day 4 of observation. Intensive therapy with HAES-LX-5 % and HES 130 had a better depressing effect on an increase in EN-1 level than other solutions

TREATMENT OF PYOINFLAMMATORY COMPLICATIONS WITH INDIVIDUALLY SELECTED OZONE DOSE IN PATIENTS WITH DIABETES

The severity of purulent-inflammatory process in patients with diabetes mellitus is determined by lymphocytotoxic test. The test shows that application of intravenous ozone therapy with individually selected ozone dose significantly decreases the spread of necrotic suppurative focus already on the third day of treatment. Granulation tissue and marginal epithelization in the wound develops on the 6-8th day of hospitalization; normalization of glycemic levels shorten of the period of the hospital stay up to 3-5 days, compared to the control group

Optimal Amount of Information Determination for Power System Steady State Estimation

On the basis of literature sources analysis, the paper provides the rationale for the necessity of considering the limited digital devices capabilities when designing closed digital control systems for the complex electrical power grids. The problem of design is decomposed into two subproblems: design of current state observation vector digital transmission systems and current controlled process state estimation; design of digital systems for optimal control vector calculation, transmission and control actions realization. The paper presents consideration of the former problem, i.e. design of current state observation vector digital transmission systems and current controlled process state estimation: the mathematical model of digital system of information transmission and state estimation considering speed and reliability of technical means of implementation is presented; the functional structure of simulation complex is developed; the paper provides the formulation of the problem of estimating the optimal amount of information about the control object state, resulting in a solution of computational experiments simulating complex. © 2021 The Author(s).The reported study was funded by RFBR, Russia, Sirius University of Science and Technology, JSC Russian Railways and Educational Fund “Talent and success”, project number 20-38-51007

Detailed analysis of the cell-inactivation mechanism by accelerated protons and light ions

Published survival data for V79 cells irradiated by monoenergetic protons, helium-3, carbon, and oxygen ions and for CHO cells irradiated by carbon ions have been analyzed using the probabilistic two-stage model of cell inactivation. Three different classes of DNA damages formed by traversing particles have been distinguished, namely severe single-track damages which might lead to cell inactivation directly, less severe damages where cell inactivation is caused by their combinations, and damages of negligible severity that can be repaired easily. Probabilities of single ions to form these damages have been assessed in dependence on their linear energy transfer (LET) values. Damage induction probabilities increase with atomic number and LET. While combined damages play crucial role at lower LET values, single-track damages dominate in high-LET regions. The yields of single-track lethal damages for protons have been compared with the Monte Carlo estimates of complex DNA lesions, indicating that lethal events correlate well with complex DNA double-strand breaks. The decrease in the single-track damage probability for protons of LET above approx. 30 keV/$\mu$m, suggested by limited experimental evidence, is discussed, together with the consequent differences in the mechanisms of biological effects between protons and heavier ions. Applications of the results in hadrontherapy treatment planning are outlined.Comment: submitted to Physics in Medicine and Biolog

Power Flows and Losses Calculation in Radial Networks by Representing the Network Topology in the Hierarchical Structure Form

This paper proposes a structured hierarchical-multilevel approach to calculating the power flows and losses of electricity in radial electrical networks with different nominal voltages at given loads and voltages of the power source. The researched electrical networks are characterized by high dimensionality, dynamism of development, but also insufficient completeness and reliability of state information. The approach is based on the representation of the initial network graph in the form of a hierarchical-multilevel structure, divided into two stages with rated voltages Unom ≤ 35 kV and Unom ≥ 35 kV, and using the traditional (manual) engineering two-stage method, where the calculation is performed in a sequence from bottom to top (stage 1) and from top to bottom (stage 2), moving along the structure of the network. The application of the above approach makes it possible to obtain an algorithm for implementation on a computer, which is characterized by universality (for an arbitrary configuration and complexity of the network), high performance and low requirements for the computer memory. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work was supported in part by the International Cooperation Project of National Natural Science Foundation of China under Grant 41761144079, in part by the Strategic Priority Research Program of the Chinese Academy of Sciences, in part by the Pan-Third Pole Environment Study for a Green Silk Road under Grant XDA20060303, in part by the K. C. Wong Education Foundation under Grant GJTD-2020-14, in part by the Research Fund for International Scientists of National Natural Science Foundation of China under Grant 42150410393, in part by the CAS PIFI Fellowship under Grant 2021PC0002, in part by the Xinjiang Tianchi Hundred Talents Program under Grant Y848041, in part by the CAS Interdisciplinary Innovation Team under Grant JCTD-2019-20, in part by the project of the Research Center of Ecology and Environment in Central Asia under Grant Y934031, and in part by the Regional Collaborative Innovation Project of Xinjiang Uygur Autonomous Regions under Grant 2020E01010