7 research outputs found
Using Community-Owned Resource Persons to Provide Early Diagnosis and Treatment and Estimate Malaria Burden at Community Level in North-Eastern Tanzania.
Although early diagnosis and prompt treatment is an important strategy for control of malaria, using fever to initiate presumptive treatment with expensive artemisinin combination therapy is a major challenge; particularly in areas with declining burden of malaria. This study was conducted using community-owned resource persons (CORPs) to provide early diagnosis and treatment of malaria, and collect data for estimation of malaria burden in four villages of Korogwe district, north-eastern Tanzania.In 2006, individuals with history of fever within 24 hours or fever (axillary temperature ≥37.5°C) at presentation were presumptively treated using sulphadoxine/pyrimethamine. Between 2007 and 2010, individuals aged five years and above, with positive rapid diagnostic tests (RDTs) were treated with artemether/lumefantrine (AL) while under-fives were treated irrespective of RDT results. Reduction in anti-malarial consumption was determined by comparing the number of cases that would have been presumptively treated and those that were actually treated based on RDTs results. Trends of malaria incidence and slide positivity rates were compared between lowlands and highlands. Of 15,729 cases attended, slide positivity rate was 20.4% and declined by >72.0% from 2008, reaching <10.0% from 2009 onwards; and the slide positivity rates were similar in lowlands and highlands from 2009 onwards. Cases with fever at presentation declined slightly, but remained at >40.0% in under-fives and >20.0% among individuals aged five years and above. With use of RDTs, cases treated with AL decreased from <58.0% in 2007 to <11.0% in 2010 and the numbers of adult courses saved were 3,284 and 1,591 in lowlands and highlands respectively. Malaria incidence declined consistently from 2008 onwards; and the highest incidence of malaria shifted from children aged <10 years to individuals aged 10-19 years from 2009. With basic training, supervision and RDTs, CORPs successfully provided early diagnosis and treatment and reduced consumption of anti-malarials. Progressively declining malaria incidence and slide positivity rates suggest that all fever cases should be tested with RDTs before treatment. Data collected by CORPs was used to plan phase 1b MSP3 malaria vaccine trial and will be used for monitoring and evaluation of different health interventions. The current situation indicates that there is a remarkable changing pattern of malaria and these areas might be moving from control to pre-elimination levels
Epidemiology of Malaria in an Area Prepared for Clinical Trials in Korogwe, North-eastern Tanzania.
Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria transmission intensities in Korogwe district, Tanzania. Four villages had passive case detection (PCD) of fever system using village health workers. Four malariometric cross-sectional surveys were conducted between November 2005 and May 2007 among individuals aged 0-19 years, living in lowland urban, lowland rural and highland strata. A total of 10,766 blood samples were collected for malaria parasite diagnosis and anaemia estimation. Blood smears were stained with Giemsa while haemoglobin level was measured by HaemoCue. Socio-economic data were collected between Jan-Apr 2006. Adjusting for the effect of age, the risk of Plasmodium falciparum parasitaemia was significantly lower in both lowland urban, (OR = 0.26; 95%CI: 0.23-0.29, p < 0.001) and highlands, (OR = 0.21; 95%CI: 0.17-0.25, p < 0.001) compared to lowland rural. Individuals aged 6-9 years in the lowland rural and 4-19 years in both lowland urban and highlands had the highest parasite prevalence, whilst children below five years in all strata had the highest parasite density. Prevalence of splenomegaly and gametocyte were also lower in both lowland urban and highlands than in lowland rural. Anaemia (Hb <11 g/dl) prevalence was lowest in the lowland urban. Availability of PCD and higher socio-economic status (SES) were associated with reduced malaria and anaemia prevalence. Higher SES and use of bed nets in the lowland urban could be the important factors for low malaria infections in this stratum. Results obtained here were used together with those from PCD and DSS in selecting a village for Phase 1b MSP3 vaccine trial, which was conducted in the study area in year 2008
Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania
In Tanzania, malaria is the major cause of morbidity and mortality, accounting for about 30% of all hospital admissions and around 15% of all hospital deaths. Severe anaemia and cerebral malaria are the two main causes of death due to malaria in Tanga, Tanzania. This was a prospective observational hospital-based study conducted from October 2004 to September 2005. Consent was sought from study participants or guardians in the wards. Finger prick blood was collected from each individual for thick and thin smears, blood sugar levels and haemoglobin estimations by Haemocue machine after admission. A total of 494 patients were clinically diagnosed and admitted as cases of severe malaria. Majority of them (55.3%) were children below the age of 5 years. Only 285 out of the total 494 (57.7%) patients had positive blood smears for malaria parasites. Adults aged 20 years and above had the highest rate of cases with fever and blood smear negative for malaria parasites. Commonest clinical manifestations of severe malaria were cerebral malaria (47.3%) and severe anaemia (14.6%), particularly in the under-fives. Case fatality was 3.2% and majority of the deaths occurred in the under-fives and adults aged 20 years and above with negative blood smears. Proper laboratory diagnosis is crucial for case management and reliable data collection. The non-specific nature of malaria symptomatologies limits the use of clinical diagnosis and the IMCI strategy. Strengthening of laboratory investigations to guide case management is recommended
Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment
Risk factors for low birth-weight in areas with varying malaria transmission in Korogwe, Tanzania: implications for malaria control
Low birth weight (LBW) is a risk factor for infant mortality,
morbidity, growth retardation, poor cognitive development, and chronic
diseases. Maternal exposure to diseases such as malaria, HIV, and
syphilis has been shown to have a significant impact on birth weight
(BW). This study was aimed at determining whether there was a
difference in rates of LBW in areas of varying malaria transmission
intensity in Korogwe, Tanzania. Retrospective data for one year (June
2004-May 2005) in three maternal and child health (MCH) clinics in the
district were analysed. Villages were stratified into three strata:
lowlands-semi urban (average altitude of 320m), lowlands-rural (below
600m) and highlands (≥600m). There was a significant decreasing
trend of rate of LBW from rural lowlands to highlands (X2 trend =7.335,
P=0.007). Adjusting for covariates, women in parity-two were at reduced
risk of delivering LBW babies compared to first parity women (OR=0.44,
95% CI 0.19-0.98, P=0.045). Similarly, the risk of LBW was higher in
women who had delayed MCH gestational booking and in women who
conceived during high malaria transmission seasons. There was high
degree of preference of digits ending with 0/5 in reporting BW in the
studied MCHs. In conclusion, a rate of LWB was high in rural lowlands
where malaria is also endemic, and was associated with high malaria
transmission seasons
Risk factors for low birth-weight in areas with varying malaria transmission in Korogwe, Tanzania: implications for malaria control
Low birth weight (LBW) is a risk factor for infant mortality,
morbidity, growth retardation, poor cognitive development, and chronic
diseases. Maternal exposure to diseases such as malaria, HIV, and
syphilis has been shown to have a significant impact on birth weight
(BW). This study was aimed at determining whether there was a
difference in rates of LBW in areas of varying malaria transmission
intensity in Korogwe, Tanzania. Retrospective data for one year (June
2004-May 2005) in three maternal and child health (MCH) clinics in the
district were analysed. Villages were stratified into three strata:
lowlands-semi urban (average altitude of 320m), lowlands-rural (below
600m) and highlands (≥600m). There was a significant decreasing
trend of rate of LBW from rural lowlands to highlands (X2 trend =7.335,
P=0.007). Adjusting for covariates, women in parity-two were at reduced
risk of delivering LBW babies compared to first parity women (OR=0.44,
95% CI 0.19-0.98, P=0.045). Similarly, the risk of LBW was higher in
women who had delayed MCH gestational booking and in women who
conceived during high malaria transmission seasons. There was high
degree of preference of digits ending with 0/5 in reporting BW in the
studied MCHs. In conclusion, a rate of LWB was high in rural lowlands
where malaria is also endemic, and was associated with high malaria
transmission seasons