A STUDY ON THE AWARENESS AND ATTITUDE TOWARDS PHARMACOVIGILANCE AND ADVERSE DRUG REACTION REPORTING AMONG NURSING STUDENTS IN A PRIVATE UNIVERSITY, MALAYSIA

Objective: This study was conducted to evaluate the knowledge and attitude towards pharmacovigilance and adverse drug reactions reporting among the nursing students in a private university, Malaysia. Methods: The survey was carried out using a pre-validated questionnaire that included demographics details and 29 survey items to evaluate the participant's knowledge and perception on adverse drug reactions and pharmacovigilance. The questionnaire was distributed to the participants (n=32) pre-final and final year nursing students after their informed consent. Results: The study results found that, there was no significant difference noticed between the mean knowledge score on ADRs reporting and pharmacovigilance of pre-final year and final year students (p>0.05). The overall mean score on knowledge was found to be 12.31. The study also observed that mean score on attitude in pre-final year and final year students were 13.24 and 16.00 respectively. There was no significant difference observed between the mean score on the perception of pre-final year and final year students (p>0.05). The overall mean score for perception on ADRs reporting and pharmacovigilance was found to be 15.06. Conclusion: The results show that nursing students who participated in the study were only moderately aware of pharmacovigilance and adverse drug reaction reporting. However, they had expressed the positive attitude towards pharmacovigilance and ADRs reporting. As future health care professionals, they are expected to have sound knowledge and positive attitude towards pharmacovigilance activities. Their knowledge and attitude would exert a strong influence on ADRs reporting

Spontaneous ovarian hyperstimulation syndrome with primary hypothyroidism: Imaging a rare entity

AbstractOvarian hyperstimulation syndrome is a disorder associated with ovulation induction and is rarely seen in pregnant women. Very few cases of spontaneous ovarian hyperstimulation syndrome have been reported in a woman who is neither pregnant nor undergoing ovulation therapy. This case report describes how spontaneous ovarian hyperstimulation syndrome is associated with primary hypothyroidism in a 25-year-old, nonpregnant woman who is not on ovulation induction therapy. Imaging and laboratory findings confirmed the diagnosis of this rare entity, which aided the clinicians in providing prompt management and in preventing further complications

EXTRACTION, ISOLATION OF ACTIVE PRINCIPLES, ANTI-BACTERIAL AND WOUND HEALING ACTIVITY OF THE MARINE ALGAL SPECIES OEDOGONIUM GLOBOSUM AND OEDOGONIUM INTERMEDIUM

Objective: Algae is the undisputed treasures of the sea and are a valuable raw material, providing unlimited opportunities for new drug discoveries. Marine algal products are in demand in the international market in the form of standardized algal extracts or semi-finished products. Methods: Aqueous and methanolic extracts of Oedogonium globosum and Oedogonium intermedium species were obtained maceration and hot percolation. The active principles from O. intermedium were isolated, purified by column chromatography, and characterized by spectral studies IR, λmax, 1HNMR and MS. The extracts of Oedogonium species were screened for their anti-microbial effects, acute dermal irritation and wound-healing activity studies. Results: Comparing to Oedogonium intermedium (45 %, 90 %, 87 %), very low extractive yields were obtained for Oedogonium globosum (10.80 %, 37 %, 28 %). At phytochemical screening, Terpenoids, Flavanoids and, Glycans were found to be present in a significant amount and upon their isolation, it was found that a collection of fractions from cold extract with Rf value in the range 0.32-0.34 as Glycans and those from the hot extract with 0.40-0.72 as Flavanoids and those from methanolic extracts with 0.23, 0.44 and 0.71 as for Terpenoids. Anti-bacterial study revealed out the fact of Oedogonium species could give higher inhibition to gram-positive than for gram-negative bacteria at (10 μg/10μl/disc) concentration. No symptoms of systemic toxicity and mortality were observed. Silver sulfadiazine, more potent in wound closure, the effect of methanolic extracts of O. intermedium (87 %) was almost at par to the standard (95 %) in action and significantly greater than O. globosum (72 %, P<0.05). Conclusion: Admittedly, Oedogonium type algal species can be known as medicinal algae with a plethora of a wide range of pharmacological activities. Thus, this research work may be considered further for extensive innovative discoveries of new lead molecules and any other pharmacological activities, in the future

Biomarkers for Antiplatelet Therapies in Acute Ischemic Stroke: A Clinical Review

Stroke is one of the world's leading causes of disability and death. Antiplatelet agents are administered to acute ischemic stroke patients as secondary prevention. Clopidogrel involves biotransformation by cytochrome P450 (CYP) enzymes into an active metabolite, and single nucleotide polymorphisms (SNPs) can influence the efficacy of this biotransformation. Despite the therapeutic advantages of aspirin, there is significant inter-individual heterogeneity in response to this antiplatelet drug. In this clinical review, the recent advances in the biomarkers of antiplatelet agents in acute ischemic stroke are discussed. The studies reviewed herein highlight the clinical relevance of antiplatelet resistance, pharmacotherapy of antiplatelet agents predicting drug response, strategies for identifying aspirin resistance, pharmacogenetic variants of antiplatelet agents, miRNAs, and extracellular vesicles (EVs) as biomarkers toward the personalized approach in the management of acute ischemic stroke. The precise pathways contributing to antiplatelet resistance are not very well known but are presumably multi-factorial. It is essential to understand the clinical relevance of clopidogrel and aspirin-related single nucleotide polymorphism (SNPs) as potential predictive and prognostic biomarkers. Prasugrel is a next-generation antiplatelet agent that prevents ADP-platelet activation by binding irreversibly to P2Y12 receptor. There are sporadic reports of prasugrel resistance and polymorphisms in the Platelet endothelial aggregation receptor-1 (PEAR1) that may contribute to a change in the pharmacodynamics response. Ticagrelor, a direct-acting P2Y12-receptor antagonist, is easily absorbed and partly metabolized to major AR-C124910XX metabolite (ARC). Ticagrelor's primary active metabolite, ARC124910XX (ARC), is formed via the most abundant hepatic cytochrome P450 (CYP) enzyme, CYP3A4, and CYP3A5. The integration of specific biomarkers, genotype as well as phenotype-related data in antiplatelet therapy stratification in patients with acute ischemic stroke will be of great clinical significance and could be used as a guiding tool for more effective, personalized therapy

Multimedia Kuronthogai / Mohan Sellappan

Project Multimedia Kuronthogai is a Final Year Project (Thesis) offered by the Faculty of Computer Science & Information Technology. This project was divided into Thesis I and Thesis II and supervised by my project supervisor Assoc. Prof. Dr. N.Selvanathan. The moderator for this project is Cik Hannyzzura Affal. Kuronthogai is a one of the Tamil anthologies. It contains 401 poems. The theme of these poems is love and the verse are of the five lands (tinais) in appropriate time. Most of the Tamil literatures are in the form of a book. Only few of them are in Multimedia environment. It is important to bring the Tamil literatures in Multimedia environment. The main objective of this project is to bring the Kuronthogai into a Multimedia environment. This Multimedia application will be a tool that will provide almost full assistance to the Tamil literature researcher. Chapter 1 of this report covered the general view of this project. This chapter covers the objective of this project, how this project was planned, the project scheduling, expected out come and the system requirement. Chapter 2 covers literature review . It contains a brief history of the Tamil literatures and how the poem in Kuronthogai were divided. The tools used for developing this application are Macromedia Director 6.0, Datagrip, Microsoft Access 7.0 and Murasu Anjal Tamil word processor. Chapter 3 covers the methodology of this application. The database design and system design were described in this chapter. Chapter 4 covers implementation, chapter 5 covers testing and chapter 6 covers evaluation

Molecular docking and identification of G-protein-coupled receptor 120 (GPR120) agonists as SARS COVID-19 MPro inhibitors

Abstract COVID-19 has become a pandemic, and any new drug for treating the disease could save millions of lives. Several drugs already in use for other diseases and medical conditions are repurposed for treating COVID-19 in an attempt to find treatment for the disease without spending research time on ADME TOX and other studies on side effects. In this exercise, the drugs repurposed are from antiviral, antibiotics, antiviral for HIV and HCV, anti-cancer, natural medicines, etc. Possible repurposing anti-diabetic GPR-120 agonists used as for SAR-CoV-2 is attempted in the study by carrying out docking of 68 GPR-120 agonists. Ten of these compounds were found to have docking scores −8.3 to −8.0, and the best docking score was observed for an arylsulfonamide and a biarylpropanoic acid belonging to GPR120 agonists previously evaluated for the treatment of type II diabetes. These GPR120 agonists could serve as start point for novel inhibitors for the discovery of drugs to treat COVID-19

Anionic Surfactant Based Topical Curcumin Nanosuspension: Fabrication, Characterization and Evaluation

Curcumin, a hydrophobic polyphenol isolated from dried rhizomes of turmeric exhibits diverse pharmacological activities including anti-bacterial. However, the clinical usefulness of curcumin was limited mainly due to low aqueous solubility and stability. The primary aim of the study was to prepare anionic surfactant based curcumin nanosuspension and to assess its in-vitro anti-bacterial efficacy on Escherichia coli in comparison with ethanolic solution of curcumin. Curcumin nanosuspension was prepared by nanoprecipitation method, characterized for the average particle size, span, uniformity, surface area, and surface morphology and assessed for its anti-bacterial activity against gram-negative bacteria Escherichia coli using agar well diffusion method. Prepared curcumin nanosuspension showed an average particle size of about 175 nm, span of about 1.5, uniformity of about 0.8, surface area of about 57 m2/g and nanoparticles were spherical in shape. Curcumin nanosuspension have shown significant (P<0.05) anti-bacterial activity against Escherichia coli at various concentrations in comparison with ethanolic solution of curcumin. We conclude that the size reduction of curcumin in nano range has increased the surface area resulting in increased aqueous solubility and reactability of curcumin, which in turn have increased the potency of curcumin nanosuspension

Carbon Nanotubes in Keeladi Potteries

Discovery of carbon nanotubes in Keeladi potterie

Spontaneous ovarian hyperstimulation syndrome with primary hypothyroidism: Imaging a rare entity

Ovarian hyperstimulation syndrome is a disorder associated with ovulation induction and is rarely seen in pregnant women. Very few cases of spontaneous ovarian hyperstimulation syndrome have been reported in a woman who is neither pregnant nor undergoing ovulation therapy. This case report describes how spontaneous ovarian hyperstimulation syndrome is associated with primary hypothyroidism in a 25-year-old, nonpregnant woman who is not on ovulation induction therapy. Imaging and laboratory findings confirmed the diagnosis of this rare entity, which aided the clinicians in providing prompt management and in preventing further complications