Functional roles of Phe12 of deacetyl-thymosin β4 in the impaired blastogenic response of uraemic T-lymphocytes

Phe12 of deacetyl-thymosin β4 is one of the structural essentials for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal12]deacetyl-thymosin β4 and [Cha12]deacetyl4 thymosin β4, were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes. The results indicated that [1-Nal12]deacetyl-thymosin β4 which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin β4, but it was slightly weaker than that of [Phe(4F)12]deacetyl-thymosin β4. However, [Cha12]deacetyl-thymosin β4 showed no restorative effect on the impaired blastogenic response of uraemic T-lymphocytes

Syntheses of two deacetyl-thymosin α1 analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients

Two deacetyl-thymosin α1 analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)21]deacetyl-thymosin α1 and [Phe(4Br)21]deacetyl-thymosin α1, respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)21deacetyl-thymosin α1, demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α1, but the other analogue, [D-Phe(4Br)21]deacetyl-thymosin α1, showed no restorative effect under the same conditions

Generalized Conformal Symmetry and Oblique AdS/CFT Correspondence for Matrix Theory

The large N behavior of Matrix theory is discussed on the basis of the previously proposed generalized conformal symmetry. The concept of `oblique' AdS/CFT correspondence, in which the conformal symmetry involves both the space-time coordinates and the string coupling constant, is proposed. Based on the explicit predictions for two-point correlators, possible implications for the Matrix-theory conjecture are discussed.Comment: LaTeX, 10 pages, 2 figures, written version of the talk presented at Strings'9

Large N limit of SYM theories with 16 supercharges from superstrings on Dp-brane backgrounds

We investigate the holographic correspondence between (p+1)-dimensional ($0\le p\le 4$) SYM theories with 16 supercharges and superstring theories on the near-horizon limit of Dp-brane backgrounds. Following an approach based on the tunneling picture, we study Euclidean superstring semi-classically along null geodesics which connect two points on the boundary of the spacetime. We extend the analysis of hep-th/0308024 and study the fermionic sector of the superstring. For $p\ne 3$, we do not have world-sheet supersymmetry, and the energies of bosonic and fermionic fluctuations do not match. By interpreting the superstring amplitudes as correlators of gauge theory operators with large R-charge J, we obtain gauge theory two-point functions including those of fermionic operators. Our approach yields results consistent with the previous supergravity analysis for the D0-branes, including the subleading part in J. Our prediction from holography is that the two-point functions for the supergravity modes are power-law behaved, even for the non-conformal ($p\ne 3$) SYM theories.Comment: 31 pages, 1 figure; v2: discussion on the consistency with a known result of supergravity analysis adde

Triple-horizon spherically symmetric spacetime and holographic principle

We present a family of spherically symmetric spacetimes, specified by the density profile of a vacuum dark energy, which have the same global structure as the de Sitter spacetime but the reduced symmetry which leads to a time-evolving and spatially inhomogeneous cosmological term. It connects smoothly two de Sitter vacua with different values of cosmological constant and corresponds to anisotropic vacuum dark fluid defined by symmetry of its stress-energy tensor which is invariant under the radial boosts. This family contains a special class distinguished by dynamics of evaporation of a cosmological horizon which evolves to the triple horizon with the finite entropy, zero temperature, zero curvature, infinite positive specific heat, and infinite scrambling time. Non-zero value of the cosmological constant in the triple-horizon spacetime is tightly fixed by quantum dynamics of evaporation of the cosmological horizon.Comment: Honorable Mentioned Essay - Gravity Research Foundation 2012; submitted to Int. J. Mod. Phys.

Semidefinite Representation of the kk-Ellipse

The $k$-ellipse is the plane algebraic curve consisting of all points whose sum of distances from $k$ given points is a fixed number. The polynomial equation defining the $k$-ellipse has degree $2^k$ if $k$ is odd and degree $2^k{-}\binom{k}{k/2}$ if $k$ is even. We express this polynomial equation as the determinant of a symmetric matrix of linear polynomials. Our representation extends to weighted $k$-ellipses and $k$-ellipsoids in arbitrary dimensions, and it leads to new geometric applications of semidefinite programming.Comment: 16 pages, 5 figure

Diamond quantum magnetometer with dc sensitivity of < 10 pT Hz−1/2^{-1/2} toward measurement of biomagnetic field

We present a sensitive diamond quantum sensor with a magnetic field sensitivity of $9.4 \pm 0.1~\mathrm{pT/\sqrt{Hz}}$ in a near-dc frequency range of 5 to 100~Hz. This sensor is based on the continuous-wave optically detected magnetic resonance of an ensemble of nitrogen-vacancy centers along the [111] direction in a diamond (111) single crystal. The long $T_{2}^{\ast} \sim 2~\mathrm{\mu s}$ in our diamond and the reduced intensity noise in laser-induced fluorescence result in remarkable sensitivity among diamond quantum sensors. Based on an Allan deviation analysis, we demonstrate that a sub-picotesla field of 0.3~pT is detectable by interrogating the magnetic field for a few thousand seconds. The sensor head is compatible with various practical applications and allows a minimum measurement distance of about 1~mm from the sensing region. The proposed sensor facilitates the practical application of diamond quantum sensors.Comment: 8 pages, 5 figure