1,163 research outputs found
Statistics of work performed on a forced quantum oscillator
Various aspects of the statistics of work performed by an external classical
force on a quantum mechanical system are elucidated for a driven harmonic
oscillator. In this special case two parameters are introduced that are
sufficient to completely characterize the force protocol. Explicit results for
the characteristic function of work and the respective probability distribution
are provided and discussed for three different types of initial states of the
oscillator: microcanonical, canonical and coherent states. Depending on the
choice of the initial state the probability distributions of the performed work
may grossly differ. This result in particular holds also true for identical
force protocols. General fluctuation and work theorems holding for
microcanonical and canonical initial states are confirmed
Exploring the Therapeutic Potential of Rosemary: An In-depth Review of its Pharmacological Properties
The pharmacological effects of rosemary plant period a wide range and include anti-inflammatory and antioxidant properties. Rosemary is shown to have its potential on Ischemic stroke because of its Anti-oxidant and Anti-inflammatory properties. It contains strong antioxidants such carnosol, which has anti-inflammatory properties, and Rosmarinus acid, which fights oxidative stress. Rosemary is an attractive possibility for treating disorders like oxidative-related diseases because of its dual activity. Additionally, Rosemary has shown neuroprotective qualities that aid in maintaining brain health and cognitive function. The aromatic components in its essential oil may improve concentration and memory. Rosemary has also been investigated for its potential in hair care, with research indicating that it can encourage hair growth. These rosemary Officinalis also have different chemical substances and compounds like Terpenes, Essential oils, Bicyclic monoterpenes, Monoterpenoids, Ester and also, we have different pharmacological activates they are Anti-oxidative, Anti-inflammatory, Anti-microbial, Anti-obesity, Anti-fungal, Anti-cancer, Anti-diabetic, Cardiovascular activity, Skin health, Neuroprotective, Gastrointestinal, Sperm motility, Anti-depressant, Anti-viral activity
Vacuum ultraviolet photoabsorption spectra of nitrile ices for their identification on Pluto
Icy bodies, such as Pluto, are known to harbor simple and complex molecules. The recent New Horizons flyby of Pluto has revealed a complex surface composed of bright and dark ice surfaces, indicating a rich chemistry based on nitrogen (N2), methane (CH4), and carbon monoxide (CO). Nitrile (CN) containing molecules such as acetonitrile (CH3CN), propionitrile (CH3CH2CN), butyronitrile (CH3CH2CH2CN), and isobutyronitrile ((CH3)2CHCN) are some of the nitrile molecules that are known to be synthesized by radiative processing of such simple ices. Through the provision of a spectral atlas for such compounds we propose that such nitriles may be identified from the ALICE payload on board New Horizons</i
A New Rapid and Sensitive Stability-Indicating UPLC Assay Method for Tolterodine Tartrate: Application in Pharmaceuticals, Human Plasma and Urine Samples
A new rapid, simple, sensitive, selective and accurate reversed-phase stability-indicating Ultra Performance Liquid Chromatography (RP-UPLC) technique was developed for the assay of Tolterodine Tartrate in pharmaceutical dosage form, human plasma and urine samples. The developed UPLC method is superior in technology to conventional HPLC with respect to speed, solvent consumption, resolution and cost of analysis. Chromatographic run time was 6 min in reversed-phase mode and ultraviolet detection was carried out at 220 nm for quantification. Efficient separation was achieved for all the degradants of Tolterodine Tartrate on BEH C18 sub-2-μm Acquity UPLC column using Trifluoroacetic acid and acetonitrile as organic solvent in a linear gradient program. The active pharmaceutical ingredient was extracted from tablet dosage form using a mixture of acetonitrile and water as diluent. The calibration graphs were linear and the method showed excellent recoveries for bulk and tablet dosage form. The test solution was found to be stable for 40 days when stored in the refrigerator between 2 and 8 °C. The developed UPLC method was validated and meets the requirements delineated by the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness. The intra-day and inter-day variation was found be less than 1%. The method was reproducible and selective for the estimation of Tolterodine Tartrate. Because the method could effectively separate the drug from its degradation products, it can be employed as a stability-indicating one
Electronic structure of PrCaMnO near the Fermi level studied by ultraviolet photoelectron and x-ray absorption spectroscopy
We have investigated the temperature-dependent changes in the near-
occupied and unoccupied states of PrCaMnO which shows the
presence of ferromagnetic and antiferromagnetic phases. The
temperature-dependent changes in the charge and orbital degrees of freedom and
associated changes in the Mn 3 - O 2 hybridization result in varied O
2 contributions to the valence band. A quantitative estimate of the charge
transfer energy () shows a larger value compared to the earlier
reported estimates. The charge localization causing the large is
discussed in terms of different models including the electronic phase
separation.Comment: 19 pages, 7 figures, To be published in Phy. Rev.
Higgsless Theory of Electroweak Symmetry Breaking from Warped Space
We study a theory of electroweak symmetry breaking without a Higgs boson,
recently suggested by Csaki et al. The theory is formulated in 5D warped space
with the gauge bosons and matter fields propagating in the bulk. In the 4D dual
picture, the theory appears as the standard model without a Higgs field, but
with an extra gauge group G which becomes strong at the TeV scale. The strong
dynamics of G breaks the electroweak symmetry, giving the masses for the W and
Z bosons and the quarks and leptons. We study corrections in 5D which are
logarithmically enhanced by the large mass ratio between the Planck and weak
scales, and show that they do not destroy the structure of the electroweak
gauge sector at the leading order. We introduce a new parameter, the ratio
between the two bulk gauge couplings, into the theory and find that it allows
us to control the scale of new physics. We also present a potentially realistic
theory accommodating quarks and leptons and discuss its implications, including
the violation of universality in the W and Z boson couplings to matter and the
spectrum of the Kaluza-Klein excitations of the gauge bosons. The theory
reproduces many successful features of the standard model, although some
cancellations may still be needed to satisfy constraints from the precision
electroweak data.Comment: 17 pages, Latex; important correction in discussions on effects from
brane terms, reference adde
Crowdsourced assessment of surgical skill proficiency in cataract surgery
OBJECTIVE: To test whether crowdsourced lay raters can accurately assess cataract surgical skills.
DESIGN: Two-armed study: independent cross-sectional and longitudinal cohorts.
SETTING: Washington University Department of Ophthalmology.
PARTICIPANTS AND METHODS: Sixteen cataract surgeons with varying experience levels submitted cataract surgery videos to be graded by 5 experts and 300+ crowdworkers masked to surgeon experience. Cross-sectional study: 50 videos from surgeons ranging from first-year resident to attending physician, pooled by years of training. Longitudinal study: 28 videos obtained at regular intervals as residents progressed through 180 cases. Surgical skill was graded using the modified Objective Structured Assessment of Technical Skill (mOSATS). Main outcome measures were overall technical performance, reliability indices, and correlation between expert and crowd mean scores.
RESULTS: Experts demonstrated high interrater reliability and accurately predicted training level, establishing construct validity for the modified OSATS. Crowd scores were correlated with (r = 0.865, p \u3c 0.0001) but consistently higher than expert scores for first, second, and third-year residents (p \u3c 0.0001, paired t-test). Longer surgery duration negatively correlated with training level (r = -0.855, p \u3c 0.0001) and expert score (r = -0.927, p \u3c 0.0001). The longitudinal dataset reproduced cross-sectional study findings for crowd and expert comparisons. A regression equation transforming crowd score plus video length into expert score was derived from the cross-sectional dataset (r
CONCLUSIONS: Crowdsourced rankings correlated with expert scores, but were not equivalent; crowd scores overestimated technical competency, especially for novice surgeons. A novel approach of adjusting crowd scores with surgery duration generated a more accurate predictive model for surgical skill. More studies are needed before crowdsourcing can be reliably used for assessing surgical proficiency
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