Chalcones, pyrazolines and aminopyrimidines as antibacterial agents

1442-14462,4–Bis-ethylamino-6-[4'-{3"-(substitutedphenyl/2'"-furanyl)-2"-propenone-1"-yl} phenyl amino]-s-triazine 5a-d have been prepared by treating ketone 4 with different substituted aromatic and heterocyclic aldehydes in the presence of alkali. These chalcones 5a-d on cyclisation with hydrazine hydrate and guani­dine nitrate to form pyrazolines 6a-d and aminopyrimidines 7a-d respectively. The structures of the synthesized compounds have been established on the bases of IR, 1H NMR and elemental analysis. The compounds have been evaluated for antibacterial activity against E. coli, S. paratyphi-A, S. aureus and B. subtilis

Synthesis and characterization of some novel isoxazoles and 1,5-benzothiazepines bearing s-triazine nucleus

473-476The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazine nucleus. These chalcones 6a-d on cyclisation with hydroxylamine hydro- chloride in presence of alkali and 2-aminothiophenol in presence of a few drops of glacial acetic acid give isoxazoles 7a-d and 1,5-benzothiazepines 8a-d respectively. All the products have been characterized by elemental analysis, IR, 1H NMR and LCMS data

Synthesis and studies of some novel s-triazine based aminopyrimidines, isoxazoles and 1,5-benzothiazepines

1707-1712An elegant synthesis of the titled compounds 7a-e, 8a-e and 9a-e have been presented starting from chalcones 6a-e based on s-triazine nucleus. These chalcones 6a-e on cyclisation with guanidine nitrate and hydroxylamine hydrochloride in the presence of alkali give aminopyrimidines 7a-e and isoxazoles 8a-e respectively. Further these chalcones 6a-e on cyclisation with 2-aminothiophenol in the presence of few drops of glacial acetic acid give 1,5-benzothiazepines 9a-e. All the products obtained from these reactions are characterized by elemental analysis, IR, ¹H NMR and mass spectral data

A Solankee 2.pmd

ABSTRACT 2-(Substitutedphenyl/ 2"-furanyl / 2"-thienyl)-3-(2'-ethylthiophene)-4-thiazolidinones (IIa-e) have been synthesized by cyclocondensation of thioglycolic acid with different Schiff-bases (Ia-e), which in turn were prepared by the action of different aromatic and heterocyclic aldehydes with thiophene-2-ethylamine. Cyclocondensation of Schiff-bases (Ia-e) with thiolactic acid resulted 2-(substitutedphenyl / 2"-furanyl / 2"-thienyl)-3-(2'-ethylthiophene)-5-methyl-4-thiazolidinones (IIa-e). The structure of newly synthesized compounds have been confirmed on the basis of IR, 1 H NMR spectral data and physical data. Key words: Schiff-bases, thioglycolic acid, thiolactic acid, 4-thiazolidinones, spectral data. EXPERIMENTAL All melting points were determined in open capillary and are uncorrected. The IR spectra were recorded on Perkin-Elmer 237 spectrophotometer

Yogesh Prajapat 1.pmd

ABSTRACT Chalones, 2,4-bis-(4'-flurophenylamino)-6-[4'-{3"-(substituted phenyl/2"'-furanyl)-2"-propenon-1"-yl} phenylamino] s-triazine (6a-e) have been prepared from ketone (5) on treatment with different aromatic/hetarocyclic aldehydes. These chalcones on cyclisation with guandiine nitrate in presence of alkali and malononitrile in presence of ammonium acetate give the corresponding aminopyrimidine (7a-e) and cyanopyridine (8a-e) derivatives respectively. All the synthesized compounds have been screened for their antibacterial activity against S. aureus (MTCC 96), B. subtilis (MTCC 441), E. coli (MTCC 443) and S. paratyphi-B. (MTCC 733). The structure of the synthesized compounds have been established on the basis of their elemental analysis and spectral studies