A Solankee 2.pmd

Abstract

ABSTRACT 2-(Substitutedphenyl/ 2"-furanyl / 2"-thienyl)-3-(2'-ethylthiophene)-4-thiazolidinones (IIa-e) have been synthesized by cyclocondensation of thioglycolic acid with different Schiff-bases (Ia-e), which in turn were prepared by the action of different aromatic and heterocyclic aldehydes with thiophene-2-ethylamine. Cyclocondensation of Schiff-bases (Ia-e) with thiolactic acid resulted 2-(substitutedphenyl / 2"-furanyl / 2"-thienyl)-3-(2'-ethylthiophene)-5-methyl-4-thiazolidinones (IIa-e). The structure of newly synthesized compounds have been confirmed on the basis of IR, 1 H NMR spectral data and physical data. Key words: Schiff-bases, thioglycolic acid, thiolactic acid, 4-thiazolidinones, spectral data. EXPERIMENTAL All melting points were determined in open capillary and are uncorrected. The IR spectra were recorded on Perkin-Elmer 237 spectrophotometer