Опыт создания полнотекстовой базы данных «МедЛиб» в научно-медицинской библиотеке Сибирского государственного медицинского университета

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Large neutrino telescope Baikal-GVD: recent status

The Baikal-GVD is a deep-underwater neutrino telescope being constructed in Lake Baikal. After the winter 2023 deployment campaign the detector consists of 3456 optical modules installed on 96 vertical strings. The status of the detector and progress in data analysis are discussed in present report. The Baikal-GVD data collected in 2018-2022 indicate the presence of cosmic neutrino flux in high-energy cascade events consistent with observations by the IceCube neutrino telescope. Analysis of track-like events results in identification of first high-energy muon neutrino candidates. These and other results from 2018-2022 data samples are reviewed in this report

Search for directional associations between Baikal Gigaton Volume Detector neutrino-induced cascades and high-energy astrophysical sources

Baikal-GVD has recently published its first measurement of the diffuse astrophysical neutrino flux, performed using high-energy cascade-like events. We further explore the Baikal-GVD cascade dataset collected in 2018-2022, with the aim to identify possible associations between the Baikal-GVD neutrinos and known astrophysical sources. We leverage the relatively high angular resolution of the Baikal-GVD neutrino telescope (2-3 deg.), made possible by the use of liquid water as the detection medium, enabling the study of astrophysical point sources even with cascade events. We estimate the telescope's sensitivity in the cascade channel for high-energy astrophysical sources and refine our analysis prescriptions using Monte-Carlo simulations. We primarily focus on cascades with energies exceeding 100 TeV, which we employ to search for correlation with radio-bright blazars. Although the currently limited neutrino sample size provides no statistically significant effects, our analysis suggests a number of possible associations with both extragalactic and Galactic sources. Specifically, we present an analysis of an observed triplet of neutrino candidate events in the Galactic plane, focusing on its potential connection with certain Galactic sources, and discuss the coincidence of cascades with several bright and flaring blazars.Comment: 10 pages, 3 figure

Studies of the ambient light of deep Baikal waters with Baikal-GVD

The Baikal-GVD neutrino detector is a deep-underwater neutrino telescope under construction and recently after the winter 2023 deployment it consists of 3456 optical modules attached on 96 vertical strings. This 3-dimensional array of photo-sensors allows to observe ambient light in the vicinity of the Baikal-GVD telescope that is associated mostly with water luminescence. Results on time and space variations of the luminescent activity are reviewed based on data collected in 2018-2022

Monitoring of optical properties of deep waters of Lake Baikal in 2021-2022

We present the results of the two-year (2021-2022) monitoring of absorption and scattering lengths of light with wavelength 400-620 nm within the effective volume of the deep underwater neutrino telescope Baikal-GVD, which were measured by a device Baikal-5D No.2. The Baikal-5D No.2. was installed during the 2021 winter expedition at a depth of 1180 m. The absorption and scattering lengths were measured every week in 9 spectral points. The device Baikal-5D No.2 also has the ability to measure detailed scattering and absorption spectra. The data obtained make it possible to estimate the range of changes in the absorption and scattering lengths over a sufficiently long period of time and to investigate the relationship between the processes of changes in absorption and scattering. An analysis was made of changes in absorption and scattering spectra for the period 2021-2022

Экзогенные и эндогенные факторы в формировании хронической обструктивной болезни легких

To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.Для определения роли эндогенных и экзогенных факторов в формировании хронической обструктивной болезни легких (ХОБЛ) у 100 пациентов (50 — группа сравнения) проведено клинико-генеалогическое обследование, включающее составление родословных с анализом 3—4 поколений, генотипирование на наиболее распространенные аллели гена α1-протеиназного ингибитора (α1-ПИ) (M, S, Z), определение уровня α1-ПИ в сыворотке крови. В формировании ХОБЛ подтверждена роль экзогенных факторов (курение, поллютанты), в то время как первичный дефицит α1-ПИ имел место только у 6% больных ХОБЛ. Таким образом, необходимо дальнейшее изучение других генетических локусов у больных ХОБЛ

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

The cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG) was identified >25 y ago; however, efforts to obtain a structure of the entire PKG enzyme or catalytic domain from any species have failed. In malaria parasites, cooperative activation of PKG triggers crucial developmental transitions throughout the complex life cycle. We have determined the cGMP-free crystallographic structures of PKG from Plasmodium falciparum and Plasmodium vivax, revealing how key structural components, including an N-terminal autoinhibitory segment (AIS), four predicted cyclic nucleotide-binding domains (CNBs), and a kinase domain (KD), are arranged when the enzyme is inactive. The four CNBs and the KD are in a pentagonal configuration, with the AIS docked in the substrate site of the KD in a swapped-domain dimeric arrangement. We show that although the protein is predominantly a monomer (the dimer is unlikely to be representative of the physiological form), the binding of the AIS is necessary to keep Plasmodium PKG inactive. A major feature is a helix serving the dual role of the N-terminal helix of the KD as well as the capping helix of the neighboring CNB. A network of connecting helices between neighboring CNBs contributes to maintaining the kinase in its inactive conformation. We propose a scheme in which cooperative binding of cGMP, beginning at the CNB closest to the KD, transmits conformational changes around the pentagonal molecule in a structural relay mechanism, enabling PKG to orchestrate rapid, highly regulated developmental switches in response to dynamic modulation of cGMP levels in the parasite

Роль полиморфизма в промоторной области гена TNF в развитии хронической обструктивной болезни легких

Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars.Исследована ассоциация полиморфизма –308G/A гена фактора некроза опухолей-α (TNF) с развитием хронической обструктивной болезни легких в двух популяциях г. Томска (сибирские татары и русские). В результате, как в группах больных, так и в группах контроля, не отмечено отклонения распределений генотипов от ожидаемых при равновесии Харди—Вайнберга. Статистически значимых различий в распределении частот аллелей среди больных с ХОБЛ и в контрольных группах получено не было (p > 0,5), в том числе и между этническими группами (русские и татары). Для татар были установлены различия в распределении генотипов между больными и контрольной группой за счет преобладания гетерозитных носителей (AG) у больных (p < 0,05). Полученные данные позволяют сделать заключение о наличии ассоциации полиморфизма –308G/A гена TNF с развитием ХОБЛ у сибирских татар