51 research outputs found
Poisson-Nernst-Planck Systems for Narrow Tubular-like Membrane Channels
We study global dynamics of the Poisson-Nernst-Planck (PNP) system for flows
of two types of ions through a narrow tubular-like membrane channel. As the
radius of the cross-section of the three-dimensional tubular-like membrane
channel approaches zero, a one-dimensional limiting PNP system is derived. This
one-dimensional limiting system differs from previous studied one-dimensional
PNP systems in that it encodes the defining geometry of the three-dimensional
membrane channel. To justify this limiting process, we show that the global
attractors of the three-dimensional PNP systems are upper semi-continuous to
that of the limiting PNP system. We then examine the dynamics of the
one-dimensional limiting PNP system. For large Debye number, the steady-state
of the one-dimensional limiting PNP system is completed analyzed using the
geometric singular perturbation theory. For a special case, an entropy-type
Lyapunov functional is constructed to show the global, asymptotic stability of
the steady-state
Creating, maintaining and questioning (hetero)relational normality in narratives about vaginal reconstruction
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value OBFC1indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated our TL polygenic trait scores (PTS) were associated with increased risk of cancer-related phenotypes
Methodological nationalism and the domestic analogy: classical resources for their critique
The Somatic Genomic Landscape of Glioblastoma
We describe the landscape of somatic genomic alterations based on multi-dimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer
Evolution systems in semiconductor device modeling: A cyclic uncoupled line analysis for the gummel map
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