Mammography-based screening program: preliminary results from a first 2-year round in a Brazilian region using mobile and fixed units

RLH, TBS and ALF made substantial contributions to the conception and design of the article, the acquisition, analysis and interpretation of the data, and drafting of the article. ECM, JSCM and NB made substantial contributions to the conception and design of the study.Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths among women worldwide. The use of mobile mammography units to offer screening to women living in remote areas is a rational strategy to increase the number of women examined. This study aimed to evaluate results from the first 2 years of a government-organized mammography screening program implemented with a mobile unit (MU) and a fixed unit (FU) in a rural county in Brazil. The program offered breast cancer screening to women living in Barretos and the surrounding area. Methods: Based on epidemiologic data, 54 238 women, aged 40 to 69 years, were eligible for breast cancer screening. The study included women examined from April 1, 2003 to March 31, 2005. The chi-square test and Bonferroni correction analyses were used to evaluate the frequencies of tumors and the importance of clinical parameters and tumor characteristics. Significance was set at p < 0.05. Results: Overall, 17 964 women underwent mammography. This represented 33.1% of eligible women in the area. A mean of 18.6 and 26.3 women per day were examined in the FU and MU, respectively. Seventy six patients were diagnosed with breast cancer (41 (54%) in the MU). This represented 4.2 cases of breast cancer per 1000 examinations. The number of cancers detected was significantly higher in women aged 60 to 69 years than in those aged 50 to 59 years (p < 0.001) or 40 to 49 years (p < 0.001). No difference was observed between women aged 40 to 49 years and those aged 50 to 59 years (p = 0.164). The proportion of tumors in the early (EC 0 and EC I) and advanced (CS III and CS IV) stages of development were 43.4% and 15.8%, respectively. Conclusions: Preliminary results indicate that this mammography screening program is feasible for implementation in a rural Brazilian territory and favor program continuation

Coastal hypoxia and eutrophication as key controls on benthic release and water column dynamics of iron and manganese

Continental shelves are a major source of iron (Fe) and manganese (Mn) to marine waters. Here, we investigate controls on benthic release of Fe and Mn and the impact on the water column in the Baltic Sea. We find high in situ benthic release rates of dissolved Fe and Mn at seasonally hypoxic sites (bottom water oxygen between 0–63 μmol L−1) receiving high inputs of organic matter. We find that benthic Fe and Mn release is sensitive to bottom water oxygen concentrations. Benthic Fe release is likely additionally controlled by Fe–sulfur redox chemistry in the surface sediment. For Mn, benthic release correlates positively with Mn oxide availability in the surface sediment. Benthic release contributes to high dissolved Fe and Mn concentrations in the water column and is amplified by repeated cycling of Fe and Mn between the sediment and overlying water through benthic release, oxidation in the water column, deposition as metal oxides, followed by reductive dissolution. Most water column Fe (∼ 80%) is present in particulate form near the seafloor. In contrast to Fe, a large percentage of the Mn remains dissolved (∼ 50%). We show that easily reducible Fe and Mn oxides are key forms of particulate Fe and Mn in suspended matter. The Baltic Sea represents a highly eutrophic, low oxygen end‐member when compared to other modern coastal systems. Our results imply that, upon continued eutrophication and deoxygenation of the coastal ocean, benthic release of dissolved Fe and Mn from continental shelves could become greater than previously thought

Coastal hypoxia and eutrophication as key controls on benthic release and water column dynamics of iron and manganese

Continental shelves are a major source of iron (Fe) and manganese (Mn) to marine waters. Here, we investigate controls on benthic release of Fe and Mn and the impact on the water column in the Baltic Sea. We find high in situ benthic release rates of dissolved Fe and Mn at seasonally hypoxic sites (bottom water oxygen between 0–63 μmol L−1) receiving high inputs of organic matter. We find that benthic Fe and Mn release is sensitive to bottom water oxygen concentrations. Benthic Fe release is likely additionally controlled by Fe–sulfur redox chemistry in the surface sediment. For Mn, benthic release correlates positively with Mn oxide availability in the surface sediment. Benthic release contributes to high dissolved Fe and Mn concentrations in the water column and is amplified by repeated cycling of Fe and Mn between the sediment and overlying water through benthic release, oxidation in the water column, deposition as metal oxides, followed by reductive dissolution. Most water column Fe (∼ 80%) is present in particulate form near the seafloor. In contrast to Fe, a large percentage of the Mn remains dissolved (∼ 50%). We show that easily reducible Fe and Mn oxides are key forms of particulate Fe and Mn in suspended matter. The Baltic Sea represents a highly eutrophic, low oxygen end‐member when compared to other modern coastal systems. Our results imply that, upon continued eutrophication and deoxygenation of the coastal ocean, benthic release of dissolved Fe and Mn from continental shelves could become greater than previously thought

Homogeneous basalts from the East Pacific Rise at 21° N: seady state magma reservoirs at moderately fast spreading centers

Fort y basaltic rocks collected by submersible during the "Cyamex" expedition (1978) on the East PacifIc Rise at 21 oN, a moderately fast spreading segment (6 cm/year opening rate) of the mid-ocean ridge, consist of angular pillow fragments and glass buds, sheet-flow slabs and samples of columnar pillars standing in collapsed fossillava pools. Most of the rocks are from the crestal are a of the Rise. The collection shows a striking petrographic homogeneity wh en compared with the range of basalts found on other segments of midocean ridges: olivine-phyric, or highly plagioclase-phyric rocks, so common in the slowspreading "Famous" are a in the Atlantic, are absent. All samples are typical lowpotassium oceanic tholeiites with a limited fractionation trend. Pillow-lavas, thin and thick sheet-flows cannot be distinguished by their major element compositions, as in the Galapagos rift which has the same spreading rate as the EPR at 21°N. Further, ferrobasalts have been described from the Galapagos rift, but do not appear in the Cyamex rocks. In the Cyamex area, olivine and plagioclase are the main silicate phases, and clinopyroxene is absent. In the pillows and sheet-flow samples, four generations of olivine and plagioclase crystals are distinguished. Samples from the fossillava pools are aphyric. The corresponding magma batches are presumed to have migrated rapidly through the magma chamber, and to have been extruded in large volumes, possibly during episodes ofhigh instantaneous opening rate. Fe-Ni and Fe-Cu-rich sulphide phases are common in an lava types as massive globules scatterred through the glass, or as microglobules decorating the walls of empty vesicles. Palagonite and Fe-Mn oxide thicknesses across the strike of the Rise indicate relative ages compatible with successive extrusions at the Rise axis. The few basaltic samples collected in the Western BrunhesMatuyama reversaI area and the Tamayo transform fault zone are not signiflcantly different from those described in the crestal area, except that they are more altered and have .thicker palagonite and manganese coats

Nature, Origin, and Evolution of the Pyrenean‐Cantabrian Junction

International audienc