Clinical trial of a new sulphonylurea in maturity-onset diabetes-hb419 (Glibenclamide)

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Some medical impressions of India, with particular reference to diabetes mellitus and cardiovascular disease

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Diabetes mellitus in the urbanized Johannesburg African

Diabetes mellitu is a common and important clinical problem in the urbanized Johannesburg African. A survey of Africans aged 30 and over attending the Baragwanath Hospital Casualty Department showed an incidence of diabetes of about 1%.1 Yet, apart from Campbell's studies on the Zulu diabetic, a search of the literature yielded little of note on diabetes in the South African Bantu. We have therefore undertaken an analysis of the records of 250 new cases of diabetes mellitus in African subjects admitted to Baragwanath Hospital during the period 1951 - 1957. These cases were selected at random and constituted at least 75% of all the new African diabetics admitted during this period

Treatment of human tapeworm infections with Yomesan: Single dose treatment in non-fasting subjects

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Haemolytic anaemia, thrombocytopenia and uraemia in eclampsia

Haemolytic anaemia has long been known as a not infrequent complication of eclampsia. Thrombocytopenia may also be associated with eclampsia, while the simultaneous occurrence of both haematological complications has recently been reported by Pritchard et al As these haematological disturbances may have an important bearing on the patbogenesis and therapy of eclampsia, it is the purpose of this paper to draw attention to their occurrence and management, by presenting 2 cases in African patients in whom eclampsia was associated with acute intravascular haemolysis, thrombocytopenia, and uraemia

Obesity in South Africa: Challenges for government and health professionals

OBJECTIVES: To review data on the prevalence, causes and health consequences of obesity in South Africa and propose interventions to prevent and treat obesity and related outcomes. METHODS: Data from existing literature were reviewed with an emphasis on changing eating and activity patterns, cultural factors, perceptions and beliefs, urbanisation and globalisation. Results of studies on the health consequences of obesity in South Africans are also reviewed. RESULTS: Shifts in dietary intakes and activity patterns to higher fat intakes and lower physical activity are contributing to a higher prevalence of obesity. Few overweight black women view themselves as overweight, and some associate thinness with HIV/AIDS. Glucose and lipid toxicity, associated with insulin resistance, play roles in the pathogenesis of the co-morbid diseases of obesity. Elevated free fatty acids in the black population predispose obese black patients to type 2 diabetes. CONCLUSION & RECOMMENDATIONS: Obesity prevention and treatment should be based on education, behaviour change, political support, intersectoral collaboration and community participation, local actions, wide inclusion of the population, adequately resourced programmes, infiltration of existing initiatives, evidence-based planning, and proper monitoring and evaluation. Interventions should have the following components: reasonable weight goals, healthful eating, physical activity and behavioural change. Genes and mutations affecting susceptibility to the development of co-morbidities of obesity and vulnerable periods of life for the development of obesity should be prioritised. Prevention should be managed in community services, identification of high-risk patients in primary healthcare services and treatment of co-morbid diseases in hospital services

IDIOPATHIC CARDIOMYOPATHY SIMULATING ORGANIC VALVE DISEASE

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VIRILIZATION CAUSED BY A LIPOID-CELL TUMOUR OF THE OVARY

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Asymptomatic bacteriuria in diabetes mellitus

A study was undertaken to determine the frequency of asymptomatic bacteriuria among 100 ambulant diabetic patients attending a diabetic outpatient clinic. At the same time, we assessed the reliability of the Uricult dip-slide method for detecting urinary bacterial growth. Significant bacteriuria occurred in 9% of the total diabetic group, largely attributable to the high prevalence in elderly diabetic women. Important characteristics of the affected diabetic patients included infection, commonly with Escherichia coli, frequently associated pyuria, good diabetic control with normal renal function and a high recurrence rate of bacteriuria after treatment. The dipslide method compared quite favourably with the laboratory culture method, but it failed to detect 2 out of 8 cases with significant bacteriuria.S. Afr. Med. J., 48, 1306 (1974)