Alguns dados sobre pragas do marupa.

bitstream/item/91462/1/IAN-BT43-p9.pd

Designing efficient contemporary ship recycling yards through discrete event simulation

Today, the ship recycling industry is going through a transitional phase in order to comply with the new regulations which are forcing ship recycling yard owners to invest and improve yards. One way to compensate these investments is to optimise the current process and increase the efficiency; however, in the literature there is a gap on detailed approach to optimization of ship recycling processes. This paper aims to develop a framework for the ship recycling industry in order to improve and optimise the ship recycling procedures. This aim is achieved through preparation of simulation models in the ARENA software with current and alternatives practices/processes for every step of ship recycling. The simulation framework developed has been applied for a ship recycling yard in EU as a case study. Bottlenecks in the current process were identified and through simulations alternative solutions were considered to optimise the process. Potential improvements for the yard with simulation approach were summarized in this paper

Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article

A study on evaluating the status of current occupational training in the ship recycling industry in Bangladesh

Essential to steel production in Bangladesh, the ship recycling industry has become a vital component of the country’s economy. After four decades of growth, Bangladesh continues to compete with India to lead the international ship recycling industry. In the Chittagong area, the ship recycling sector, and related downstream activities, provides employment and resources to nearby communities. Despite its profitability and income generation, poor working practices and low environmental standards tarnish the image of the sector at national and international levels. Numerous accidents and fatalities in ship recycling processes highlight the lack of adequate Occupational Health and Safety (OHS) standards. Seasonal migrant workers, many of whom unfamiliar with industrial settings, represent the majority of workers in ship recycling yards. Recruited by subcontractors, most of the workers in Bangladesh lack sufficient hazard awareness and basic safety requirements necessary to work in a ship recycling yard. For these reasons, as identified by the Bangladesh High Court and subsequent national rules, training of workers must be addressed in yards in Bangladesh. In this study, associated with the IMO-NORAD SENSREC project, existing conditions, solely about workers’ training, has been addressed, assessed, and compared in accordance with IMO’s Hong Kong Convention and ILO requirements, where detailed recommendations were provided to enhance OHS training in the yards

An approach to advance circular practices in the maritime industry through a database as a bridging solution

The concept of maritime circularity has gained increasing attention to address challenges arising from the net-zero targets of the maritime industry. The circular economy provides potential solutions to address these challenges through reuse, remanufacturing, and recycling practices. However, the industry faces complex challenges, including inefficient reverse supply chains, a lack of awareness about circular economy principles, standardisation issues, and the need for digital infrastructure to provide vital information in the sector. These challenges prevent the implementation of circularity practices, as access to crucial data throughout the vessel’s life cycle is obstructed. This novel research aims to create a robust first-of-its-kind database solution specifically designed to support the industry’s shift towards circularity. The database will facilitate fast and transparent information flow between the stakeholders, providing foundations for asset tracking and a robust reverse supply chain. A case study was conducted to show that a database could help extract higher financial value from end-of-life ships by over 80%. The ageing fleet increases the urgency of utilising such a database, which could be a pivotal strategy for a sustainable and circular industry. This digital solution offers significant benefits to all industry stakeholders and allows holistic resource management, influencing maritime operations’ sustainability, resilience, and profitability

Supramolecular peptide nanofiber morphology affects mechanotransduction of stem cells

Chirality and morphology are essential factors for protein function and interactions with other biomacromolecules. Extracellular matrix (ECM) proteins are also similar to other proteins in this sense; however, the complexity of the natural ECM makes it difficult to study these factors at the cellular level. The synthetic peptide nanomaterials harbor great promise in mimicking specific ECM molecules as model systems. In this work, we demonstrate that mechanosensory responses of stem cells are directly regulated by the chirality and morphology of ECM-mimetic peptide nanofibers with strictly controlled characteristics. Structural signals presented on l-amino acid containing cylindrical nanofibers (l-VV) favored the formation of integrin β1-based focal adhesion complexes, which increased the osteogenic potential of stem cells through the activation of nuclear YAP. On the other hand, twisted ribbon-like nanofibers (l-FF and d-FF) guided the cells into round shapes and decreased the formation of focal adhesion complexes, which resulted in the confinement of YAP proteins in the cytosol and a corresponding decrease in osteogenic potential. Interestingly, the d-form of twisted-ribbon like nanofibers (d-FF) increased the chondrogenic potential of stem cells more than their l-form (l-FF). Our results provide new insights into the importance and relevance of morphology and chirality of nanomaterials in their interactions with cells and reveal that precise control over the chemical and physical properties of nanostructures can affect stem cell fate even without the incorporation of specific epitopes

Towards engineering heart tissues from bioprinted cardiac spheroids.

Currentin vivoandin vitromodels fail to accurately recapitulate the human heart microenvironment for biomedical applications. This study explores the use of cardiac spheroids (CSs) to biofabricate advancedin vitromodels of the human heart. CSs were created from human cardiac myocytes, fibroblasts and endothelial cells (ECs), mixed within optimal alginate/gelatin hydrogels and then bioprinted on a microelectrode plate for drug testing. Bioprinted CSs maintained their structure and viability for at least 30 d after printing. Vascular endothelial growth factor (VEGF) promoted EC branching from CSs within hydrogels. Alginate/gelatin-based hydrogels enabled spheroids fusion, which was further facilitated by addition of VEGF. Bioprinted CSs contracted spontaneously and under stimulation, allowing to record contractile and electrical signals on the microelectrode plates for industrial applications. Taken together, our findings indicate that bioprinted CSs can be used to biofabricate human heart tissues for long termin vitrotesting. This has the potential to be used to study biochemical, physiological and pharmacological features of human heart tissue

Structure, mechanism, and inhibition of Hedgehog acyltransferase

The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi-pass transmembrane enzyme Hedgehog acyltransferase (HHAT). We present the high-resolution cryo-EM structure of HHAT bound to substrate analog palmityl-coenzyme A and a SHH-mimetic megabody, revealing a heme group bound to HHAT that is essential for HHAT function. A structure of HHAT bound to potent small-molecule inhibitor IMP-1575 revealed conformational changes in the active site that occlude substrate binding. Our multidisciplinary analysis provides a detailed view of the mechanism by which HHAT adapts the membrane environment to transfer an acyl chain across the endoplasmic reticulum membrane. This structure of a membrane-bound O-acyltransferase (MBOAT) superfamily member provides a blueprint for other protein-substrate MBOATs and a template for future drug discovery

Optical gain in 1.3-μm electrically driven dilute nitride VCSOAs

We report the observation of room-temperature optical gain at 1.3 μm in electrically driven dilute nitride vertical cavity semiconductor optical amplifiers. The gain is calculated with respect to injected power for samples with and without a confinement aperture. At lower injected powers, a gain of almost 10 dB is observed in both samples. At injection powers over 5 nW, the gain is observed to decrease. For nearly all investigated power levels, the sample with confinement aperture gives slightly higher gain