1,776 research outputs found
Recommended from our members
Multibunch energy and spectrum control in the SLC High Energy Linac
Three intense bunches (two electron and one positron) are accelerated on each rf pulse in the SLC Linac. Careful control of the energy and energy spectrum of each bunch is needed to provide acceptable beams at the collision point and the positron productive target. The required rf amplitude, timing, and phase adjustments can be calculated and adjusted in real time to correct for changing conditions. BNS damping and energy feedback systems reduce the available reserve energy, which is limited. Observations and stability of actual beams are reviewed. Implications for a future collider are discussed. 10 refs., 3 figs., 1 tab
Recommended from our members
The trajectory control in the SLC linac
Due to wake field effects, the trajectories of accelerated beams in the Linac should be well maintained to avoid severe beam breakup. In order to maintain a small emittance at the end of the Linac, the tolerance on the trajectory deviations become tighter when the beam intensities increase. The existing two beam trajectory correction method works well when the theoretical model agrees with the real machine lattice. Unknown energy deviations along the linac as well as wake field effects can cause the real lattice to deviate from the model. This makes the trajectory correction difficult. Several automated procedures have been developed to solve these problems. They are: an automated procedure to frequently steer the whole Linac by dividing the Linac into several small regions; an automated procedure to empirically correct the model to fit the real lattice and eight trajectory correcting feedback loops along the linac and steering through the collimator region with restricted corrector strengths and a restricted number of correctors. 6 refs., 2 figs
Computer-aided design of nano-filter construction using DNA self-assembly
Computer-aided design plays a fundamental role in both top-down and bottom-up nano-system fabrication. This paper presents a bottom-up nano-filter patterning process based on DNA self-assembly. In this study we designed a new method to construct fully designed nano-filters with the pores between 5 nm and 9 nm in diameter. Our calculations illustrated that by constructing such a nano-filter we would be able to separate many molecules
Metacarpal cortical bone loss and osteoporotic fractures in the Coimbra Identified Skeletal Collection
There has been considerable progress in recent years in our understanding of the patterns of cortical bone loss in the second metacarpal in archeological skeletal samples. Nevertheless, cortical data from reference skeletal collections are insufficient, and the possible connection of metacarpal cortical parameters with osteoporotic fractures has not been thoroughly addressed. As such, this article aims to identify and explain sex-specific and age-associated metacarpal cortical bone loss in a large sample (N = 302females: 154/males: 148) from the Coimbra Identified Skeletal Collection. Another objective is to evaluate the association of cortical and demographic features with osteoporotic fractures. Age-related endocortical bone loss is significant in women but not evident in men. Periosteal accretion of the bone is absent in both sexes. Overall, there is a net loss of the cortical bone in women, whereas cortical bone strength seems to be preserved in men. The prevalence of osteoporotic fractures is similar in both sexes, with age at death significantly influencing the probability of exhibiting a fracture. Metacarpal cortical index does not seem to be an independent risk factor for osteoporotic fractures in this sample.Fundacao para a Ciencia e a TecnologiaPortuguese Foundation for Science and Technology [SFRH/BPD/74015/2010
The Slavic NBN founder mutation: a role for reproductive fitness?
The vast majority of patients with Nijmegen Breakage Syndrome (NBS) are of Slavic origin and carry a deleterious deletion (c.657del5; rs587776650) in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may thus be considered a Slavic founder mutation. Notably, not a single parenthood of a homozygous c.657del5 carrier has been reported to date, while heterozygous carriers do reproduce but have an increased cancer risk. These observations seem to conflict with the considerable carrier frequency of c.657del5 of 0.5% to 1% as observed in different Slavic populations because deleterious mutations would be eliminated quite rapidly by purifying selection. Therefore, we propose that heterozygous c.657del5 carriers have increased reproductive success, i.e., that the mutation confers heterozygote advantage. In fact, in our cohort study of the reproductive history of 24 NBS pedigrees from the Czech Republic, we observed that female carriers gave birth to more children on average than female non-carriers, while no such reproductive differences were observed for males. We also estimate that c.657del5 likely occurred less than 300 generations ago, thus supporting the view that the original mutation predated the historic split and subsequent spread of the 'Slavic people'. We surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination, akin to the previously described role of the DNA repair genes BRCA1 and BRCA2
Limitations of Self-Assembly at Temperature One (extended abstract)
We prove that if a subset X of the integer Cartesian plane weakly
self-assembles at temperature 1 in a deterministic (Winfree) tile assembly
system satisfying a natural condition known as *pumpability*, then X is a
finite union of doubly periodic sets. This shows that only the most simple of
infinite shapes and patterns can be constructed using pumpable temperature 1
tile assembly systems, and gives strong evidence for the thesis that
temperature 2 or higher is required to carry out general-purpose computation in
a tile assembly system. Finally, we show that general-purpose computation is
possible at temperature 1 if negative glue strengths are allowed in the tile
assembly model
Recommended from our members
Dispersion and Betatron Matching into the Linac
In high energy linear colliders, the low emittance beam from a damping ring has to be preserved all the way to the linac, in the linac and to the interaction point. In particular, the Ring-To-Linac (RTL) section of the SLAC Linear Collider (SLC) should provide an exact betatron and dispersion match from the damping ring to the linac. A beam with a non-zero dispersion shows up immediately as an increased emittance, while with a betatron mismatch the beam filaments in the linac. Experimental tests and tuning procedures have shown that the linearized beta matching algorithms are insufficient if the actual transport line has some unknown errors not included in the model. Also, adjusting quadrupole strengths steers the beam if it is offset in the quadrupole magnets. These and other effects have lead to a lengthy tuning process, which in the end improves the matching, but is not optimal. Different ideas will be discussed which should improve this matching procedure and make it a more reliable, faster and simpler process. 5 refs., 2 figs
DNA cruciform arms nucleate through a correlated but non-synchronous cooperative mechanism
Inverted repeat (IR) sequences in DNA can form non-canonical cruciform
structures to relieve torsional stress. We use Monte Carlo simulations of a
recently developed coarse-grained model of DNA to demonstrate that the
nucleation of a cruciform can proceed through a cooperative mechanism. Firstly,
a twist-induced denaturation bubble must diffuse so that its midpoint is near
the centre of symmetry of the IR sequence. Secondly, bubble fluctuations must
be large enough to allow one of the arms to form a small number of hairpin
bonds. Once the first arm is partially formed, the second arm can rapidly grow
to a similar size. Because bubbles can twist back on themselves, they need
considerably fewer bases to resolve torsional stress than the final cruciform
state does. The initially stabilised cruciform therefore continues to grow,
which typically proceeds synchronously, reminiscent of the S-type mechanism of
cruciform formation. By using umbrella sampling techniques we calculate, for
different temperatures and superhelical densities, the free energy as a
function of the number of bonds in each cruciform along the correlated but
non-synchronous nucleation pathways we observed in direct simulations.Comment: 12 pages main paper + 11 pages supplementary dat
Observation of the Dynamic Beta Effect at CESR with CLEO
Using the silicon strip detector of the CLEO experiment operating at the
Cornell Electron-positron Storage Ring (CESR), we have observed that the
horizontal size of the luminous region decreases in the presence of the
beam-beam interaction from what is expected without the beam-beam interaction.
The dependence on the bunch current agrees with the prediction of the dynamic
beta effect. This is the first direct observation of the effect.Comment: 9 page uuencoded postscript file, postscritp file also available
through http://w4.lns.cornell.edu/public/CLNS, submitted to Phys. Rev.
- …