Analysis and Design of Detection for Liver Cancer using Particle Swarm Optimization and Decision Tree

Liver cancer is taken as a major cause of death all over the world. According to WHO (World Health Organization) every year 9.6 million peoples are died due to cancer worldwide. It is one of the eighth most leading causes of death in women and fifth in men as reported by the American Cancer Society. The number of death rate due to cancer is projected to increase by45 percent in between 2008 to 2030. The most common cancers are lung, breast, and liver, colorectal. Approximately 7, 82,000 peoples are died due to liver cancer each year. The most efficient way to decrease the death rate cause of liver cancer is to treat the diseases in the initial stage. Early treatment depends upon the early diagnosis, which depends on reliable diagnosis methods. CT imaging is one of the most common and important technique and it acts as an imaging tool for evaluating the patients with intuition of liver cancer. The diagnosis of liver cancer has historically been made manually by a skilled radiologist, who relied on their expertise and personal judgement to reach a conclusion. The main objective of this paper is to develop the automatic methods based on machine learning approach for accurate detection of liver cancer in order to help radiologists in the clinical practice. The paper primary contribution to the process of liver cancer lesion classification and automatic detection for clinical diagnosis. For the purpose of detecting liver cancer lesions, the best approaches based on PSO and DPSO have been given. With the help of the C4.5 decision tree classifier, wavelet-based statistical and morphological features were retrieved and categorised

Service and Repeated Volley Skills among Volleyball Players: A Relationship Study

Present study examined the relationship between Service and Repeated Volley Skills among Volleyball Players. Total twenty five (N-25) female volleyball players their age ranged from 17 to 19 years were selected as subject from Navodaya Vidyalaya School, Sector25, Chandigarh. Service and Repeated Volley abilities were measured by administrating RussellLange Volleyball Skill Test. The data was analyzed statistically by computing Pearson Product Moment Correlation method to find out the relationship between service and repeated volley skills among female volleyball players. Results revealed the significant relationship between service with repeated volleys as the coefficient of correlation value of .593 was statistically significant at 0.01 level

Assessment of prescription writing practices in a government tertiary care hospital in Haryana by using WHO prescribing indicators

Background: Writing a prescription is a combination of science and art. Good quality prescriptions are a sign of prescriber’s expertise. World Health Organization has defined certain parameters to promote rational drug use in all countries. This study was designed to assess the prescription writing practices in a government tertiary care hospital in Haryana by using WHO prescribing indicators.Methods: A total of 2155 prescriptions were evaluated. Each prescription was evaluated for average number of drugs prescribed per patient per encounter, percentage of drugs prescribed by generic name, percentage of encounters with an antibiotic prescribed, percentage of encounters with an injection prescribed and percentage of medicines from Essential drug list prescribed. These indicators help us to check polypharmacy, practice of prescribing drugs by brand names, antibiotic overuse, preference of injectables and non-adherence to Essential drug list.Results: The average number of drugs prescribed per patient per encounter was calculated to be 3.25±0.24. The percentage of medicines prescribed by generic names was 35.89%. Percentage of encounters with an antibiotic prescribed was 48.21 % and with an injection prescribed was 1.85%. The percentage of medicines form NLEM was 76.36%.Conclusions: The values of WHO prescribing indicators obtained from this study show that there are some areas where the prescribers need to improve their prescribing practices

A BRIEF DESCRIPTION ON VALIDATION: AN OVERVIEW

ABSTRACT Validation is the mean of catering enormous benefits to even more than the acceptable quality level which in the global standard scale. Lending importance to validation is increasingly profound in recent years. Validation is the art of designing and practicing the designed steps alongside with the documentation. Validation and quality assurance will go hand in hand, ensuring the through quality for the products. Hence, an emphasis made on to review that gives a detailed, overview of validation, Validation Documents, and reports. Additionally a view of validation against the elements of process validation and need of validation also describes in this review

Design expert assisted mathematical optimization of solubility and study of fast disintegrating tablets of Lercanidipine Hydrochloride

90% of drugs being researched today, posses poor solubility setback which inturn renders  the drug with slower rate of absorption from the buccal route; hence dissolution is the rate limiting step for such lipophilic drugs. So, there is a need to keep a check on the dissolution profile of these drugs to ensure maximum therapeutic utilization. The dissolution rate therefore becomes a primary factor which governs the rate and extent of its absorption. Enormous work is being performed in the field of enhancement of solubility and dissolution behaviour of such drugs. Advancements and innovations have developed solid dispersion (SD) technique as the novel method for the solubility enhancement. Precision of dosing and patient's compliance is a crucial prerequisite for the management of chronic Antihypertensive treatment, So there arised a need to formulate a system which should resolve the difficulties associated with conventional tablets. This issue can be better tackled with the formulation of orally fast disintegrating tablets. The aim of the present study was to improve the solubility and dissolution rate of Lercanidipine hydrochloride (LRH) by formulating a solid dispersion with Polyvinyl pyrollidine (PVP-K30) and Guargum. Full Factorial designs are exploited to learn and research the effects of different variables on the quality determinant parameters. An appropriate statistical model was selected for the scrutiny of the enhanced dissolution pattern. Finally, these solid dispersions were incorporated into fast disintegrating tablets. Keywords: Lercanidipine Hydrochloride, Solid dispersion, Statistical design approach, Melt fusion method, Fast disintegrating tablet, In vivo studie

Antibiotics-related adverse drug reactions at a tertiary care hospital in North India

Background: Antibiotics are considered to be commonly used drugs in hospital setting due to higher prevalence of infectious diseases especially in India. So, the present study was conducted to assess the incidence of adverse drug reactions (ADRs) due to antibiotics and analyze for causality of adverse drug events reported.Methods: The present retrospective and observational, study was conducted in BPS GMC for women, Khanpur Kalan, Sonepat, Haryana which is a 500 bedded government medical hospital situated in rural area between March 2016 to February 2019 (i.e., 3 years). Patients of either sex or age who developed ADRs by any route were included in the study.Results: 300 (38.65%) cases were reported due to antibiotics out of total 776 ADR cases. 3% cases were serious. Adults (65%) were found to be most commonly affected by ADRs. Among antibiotics, cephalosporins and penicillins (15.98%) were the major culprit to cause adverse events followed by nitroimidazoles (15.2%) and antitubercular drugs and fluoro quinolones (13.16%). The most affected organ system was skin (49.33%) followed by the gastrointestinal system (33%). As per WHO scale of causality assessment, 33.33% and 67.67% reported cases were found to probably and possibly related to adverse events respectively.Conclusions: Antibiotics are most commonly prescribed drugs so its monitoring regarding ADRs may benefit the clinicians in early identification and management of ADRs so that quality of life of patient can be safeguarded at an earliest

A COMPREHENSIVE ANALYSIS OF DRUG PRESCRIBING PRACTICES OF DOCTORS AND COMPLETENESS OF PRESCRIPTION IN A GOVERNMENT MEDICAL COLLEGE IN NORTHERN INDIA

Objective: This study was designed to analyze the drug prescribing practices of doctors and completeness of prescriptions in a government medical college in Northern India. Methods: A total of 2155 prescriptions were evaluated for adequacy of information related to prescribed drugs and completeness of information related to patients and doctors. Results: The weight of the patient was written only in 1.90% prescriptions. The diagnosis was not written on 43.85% prescriptions. A total number of drugs prescribed in all the prescriptions was 6998. The average number of drugs per prescription was found to be 3.25±0.24. Out of these, 64.10% were prescribed by brand names. About 69.14% of drugs were prescribed in the form of tablets. Route of administration was not found to be mentioned for 86.08% drugs. For 53.90% drugs, dose was not mentioned. The name of the prescribing doctor was mentioned in 1.95% prescriptions only. Conclusion: The study revealed that many prescriptions lacked crucial components of information pertaining to the drugs prescribed and the prescribing doctor. There is a vast scope for improvement by the prescribers

COMPARISON OF SAFETY OF LATANOPROST WITH PRESERVATIVE BENZALKONIUM CHLORIDE (BAK) VERSUS BAK-FREE TRAVOPROST IN PRIMARY OPEN-ANGLE GLAUCOMA

Objective: The objective of this study was to compare the safety of BAK-preserved latanoprost versus travoprost BAK-free ophthalmic solution in the primary open-angle glaucoma (POAG). Methods: Prospective, open-labeled, and randomized comparative study conducted in tertiary care hospital. Forty patients were enrolled and divided into 20 patients in each group: Group A topical latanoprost (0.005%) with BAK and Group B topical BAK-free travoprost (0.004%). Safety assessment was done by following parameters – Schrimer test (ST), tear break-up time (TBUT), and ocular surface disease index (OSDI). Results: ST and TBUT were calculated at baseline, 1 month, 2 months, 3 months, and 4 months and OSDI scores were calculated at baseline, 2 months and 4 months. Group A and B were compared using ST, TBUT, and OSDI scores. Group B showed statistically significant results (p<0.05). Conclusion: Topical BAK-free travoprost is more tolerable than BAK-preserved latanoprostin POAG

New corona virus: is just a tip of iceberg?

The world is again experiencing a global viral epidemic of zoonotic origin. As of March 30, 785807 confirmed cases of coronavirus disease 2019 (COVID-19) and 37820 deaths had been reported in more than 120 countries. Strenuous efforts are being made by various countries of the world to halt transmission through shutting down transport, quarantining entire cities and enforcing the use of face masks. International flights have been cancelled and affected cruise ships quarantined. As in all outbreaks, there is an urgent need to develop effective diagnostics, therapeutics and vaccines. Several experimental diagnostic platforms are already in use in China and elsewhere. The whole-genome sequence of SARS-CoV-2 has been obtained and shared widely. Several potential treatments have been proposed, however, no antiviral treatment has been approved for the novel coronavirus, and despite two outbreaks of novel coronaviruses in the past two decades, vaccine development is still in its infancy