天涯故鄉

Some genes regulate phenotypes that are either present or absent. They are often important regulators of developmental switches and are involved in morphological evolution. We have little understanding of the molecular mechanisms by which these absence/presence gene functions have evolved, because the phenotype and fitness of molecular intermediate forms are unknown. Here, we studied the sex-determining switch of 14 natural sequence variants of the csd gene among 76 genotypes of the honeybee (Apis mellifera). Heterozygous genotypes (different specificities) of the csd gene determine femaleness, while hemizygous genotypes (single specificity) determine maleness. Homozygous genotypes of the csd gene (same specificity) are lethal [1-6]. We found that at least five amino acid differences and length variation between Csd specificities in the specifying domain (PSD) were sufficient to regularly induce femaleness. We estimated that, on average, six pairwise amino acid differences evolved under positive selection [7-9]. We also identified a natural evolutionary intermediate that showed only three amino acid length differences in the PSD relative to its parental allele. This genotype showed an intermediate fitness because it implemented lethality regularly and induced femaleness infrequently (i.e., incomplete, penetrance). We suggest incomplete penetrance as a mechanism through which new molecular switches can gradually and adaptively evolve

Impact of DST (Daylight Saving Time) on Major Trauma: A European Cohort Study

(1) Background: Approximately 73 countries worldwide implemented a daylight saving time (DST) policy: setting their clocks forward in spring and back in fall. The main purpose of this practice is to save electricity. The aim of the present study was to find out how DST affects the incidence and impact of seriously injured patients. (2) Methods: In a retrospective, multi-center study, we used the data recorded in the TraumaRegister DGU® (TR-DGU) between 2003 and 2017 from Germany, Switzerland, and Austria. We compared the included cases 1 week before and after DST. (3) Results: After DST from standard time to summertime, we found an increased incidence of accidents of motorcyclists up to 51.58%. The result is consistent with other studies. (4) Conclusion: However, our results should be interpreted as a tendency. Other influencing factors, such as time of day and weather conditions, were not considered

South Atlantic Crossing (SACROSS) - Cruise No. M133: 15.12.2016-13.01.2017, Cape Town (South Africa)-Stanley (Falklands)

The cruise M133 SACROSS (South Atlantic Crossing) was a multidisciplinary ocean survey of the South Atlantic gyre roughly along 34.5° S. This transect is covered by the international SAMOC moored array and also the path of the internationally agreed AX18 XBT line. Most of the measurements were based on using underway methods including near-surface water sampling for the determination of SST, and SSS as well as shipboard ADCP current observations. Moreover, an underway CTD allowed to sample the upper 300-400 m every hour. Chemical analysis of surface waters as well as atmospheric parameter were of scientific interest to both compare different regions with each other but also to document long term trends. At the western and eastern boundary current regime full water column water mass properties were measured. Upper ocean 10-700m plankton assemblages allow improving the calibration of sediment proxies. Water samples for later lab-based biodiversity analysis were taken. A number of smaller student projects were carried out as part of a global ocean learning and capacity building effort. Finally, continuous swath bathymetry mapping was made, and a number of floats and drifters were launched in support of the global ocean observing system arrays. The cruise was very successful, all objectives were reached, and the measurements were carried out as planned

Soft Law as a New Mode of Governance: A Legal Perspective

After a brief review of the history and typology of soft law in public international law, we approach the concept deductively. We reject the binary view and subscribe to the continuum view. Building on the idea of graduated normativity and on the prototype theory of concepts, we submit that soft law is in the penumbra of law. It can be distinguished from purely political documents more or less readily, depending on its closeness to the prototype of law. Insights gained by the study of public international soft law are relevant to EC and EU soft law despite some differences between those legal orders. European soft law is created by institutions, Member States, and private actors. The legal effects of soft law acts can be clustered according to their relation to hard law. Both practical and normative considerations motivate reliance on soft law. An examination of the soft legal consequences of a disregard of soft law shows that compliance control mechanisms for hard and soft international law are converging. Moreover, some factors of compliance are independent of the theoretical hardness or softness of a given norm. In a legal policy perspective, the proliferation of soft law carries both dangers and benefits. Especially soft acts with a lawplus function do not weaken the respective regimes, but perfect them