12 research outputs found
Of Bounces, Branes and Bounds
Some recent studies have considered a Randall-Sundrum-like brane world
evolving in the background of an anti-de Sitter Reissner-Nordstrom black hole.
For this scenario, it has been shown that, when the bulk charge is
non-vanishing, a singularity-free ``bounce'' universe will always be obtained.
However, for the physically relevant case of a de Sitter brane world, we have
recently argued that, from a holographic (c-theorem) perspective, such brane
worlds may not be physically viable. In the current paper, we reconsider the
validity of such models by appealing to the so-called ``causal entropy bound''.
In this framework, a paradoxical outcome is obtained: these brane worlds are
indeed holographically viable, provided that the bulk charge is not too small.
We go on to argue that this new finding is likely the more reliable one.Comment: 15 pages, Revtex; references added and very minor change
Branonium
We study the bound states of brane/antibrane systems by examining the motion
of a probe antibrane moving in the background fields of N source branes. The
classical system resembles the point-particle central force problem, and the
orbits can be solved by quadrature. Generically the antibrane has orbits which
are not closed on themselves. An important special case occurs for some
Dp-branes moving in three transverse dimensions, in which case the orbits may
be obtained in closed form, giving the standard conic sections but with a
nonstandard time evolution along the orbit. Somewhat surprisingly, in this case
the resulting elliptical orbits are exact solutions, and do not simply apply in
the limit of asymptotically-large separation or non-relativistic velocities.
The orbits eventually decay through the radiation of massless modes into the
bulk and onto the branes, and we estimate this decay time. Applications of
these orbits to cosmology are discussed in a companion paper.Comment: 34 pages, LaTeX, 4 figures, uses JHEP
Cosmological Spacetimes from Negative Tension Brane Backgrounds
We identify a time-dependent class of metrics with potential applications to
cosmology, which emerge from negative-tension branes. The cosmology is based on
a general class of solutions to Einstein-dilaton-Maxwell theory, presented in
{hep-th/0106120}. We argue that solutions with hyperbolic or planar symmetry
describe the gravitational interactions of a pair of negative-tension
-branes. These spacetimes are static near each brane, but become
time-dependent and expanding at late epoch -- in some cases asymptotically
approaching flat space. We interpret this expansion as being the spacetime's
response to the branes' presence. The time-dependent regions provide explicit
examples of cosmological spacetimes with past horizons and no past naked
singularities. The past horizons can be interpreted as S-branes. We prove that
the singularities in the static regions are repulsive to time-like geodesics,
extract a cosmological `bounce' interpretation, compute the explicit charge and
tension of the branes, analyse the classical stability of the solution (in
particular of the horizons) and study particle production, deriving a general
expression for Hawking's temperature as well as the associated entropy.Comment: 43 pages, 8 figures. Published versio
Pretreatment and early intratreatment prediction of clinicopathologic response of head and neck cancer to chemoradiotherapy using 1H-MRS
A Glass Half Full? Enduring Small Business Frustrations under the Consumer Review Fairness Act of 2016
Predicting response to neoadjuvant chemotherapy in primary breast cancer using volumetric helical perfusion computed tomography: a preliminary study
To investigate whether CT-derived vascular parameters in primary breast cancer predict complete pathological response (pCR) to neoadjuvant chemotherapy (NAC).Twenty prospective patients with primary breast cancer due for NAC underwent volumetric helical perfusion CT to derive whole tumour regional blood flow (BF), blood volume (BV) and flow extraction product (FE) by deconvolution analysis. A pCR was achieved if no residual invasive cancer was detectable on pathological examination. Relationships between baseline BF, BV, FE, tumour size and volume, and pCR were examined using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was performed to assess the parameter best able to predict response. Intra- and inter-observer variability was assessed using Bland-Altman statistics.Seventeen out of 20 patients completed NAC with four achieving a pCR. Baseline BF and FE were higher in patients who achieved a pCR compared with those who did not (P = 0.032); tumour size and volume were not significantly different (P > 0.05). ROC analysis revealed that BF and FE were able to identify responders effectively (AUC = 0.87; P = 0.03). There was good intra- and inter-observer agreement.Primary breast cancers which exhibited higher levels of perfusion before treatment were more likely to achieve a pCR to NAC.aEuro cent CT-derived vascular parameters may be useful in breast cancer treatment.aEuro cent Perfusion CT can help predict response to neoadjuvant chemotherapy in breast cancer.aEuro cent Baseline blood flow and flow extraction product are higher in complete pathological responders.</p