1,539 research outputs found

    Desenvolvimento socioambiental: um passo com o projeto Rondon

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    Trabalho apresentado no II Congresso Nacional do PROJETO RONDON, realizado em Florianópolis, SC, no período de 23 a 25 de setembro de 2015 - Universidade Federal de Santa Catarina.Este trabalho relata as atividades desenvolvidas durante a Operação Velho Monge do Projeto Rondon realizada no município de Peritoró-MA junto à equipe da UTFPR câmpus Pato Branco dentro da área temática de meio ambiente. As atividades ocorreram durante o período de 20 de janeiro à 01 de fevereiro de 2014. Foram ofertadas à comunidade do município oficinas de Tratamento de Água e Higiene, Fabricação de Sabão Caseiro Utilizando Óleos e Gorduras Residuais e Fabricação de Papel Reciclado, esta última com foco no público infantil. A oficina de Tratamento de Água e Higiene foi acompanhada por grande parte do corpo de agentes comunitários de saúde de Peritoró e moradores locais e a oficina de Fabricação de Sabão Caseiro por vários moradores. Diversas comunidades do município foram atendidas com as oficinas, tanto na área urbana quanto rural, tendo sido executadas em locais públicos como escolas municipais e no centro paroquial. Foi confeccionado e entregue aos participantes de todas as oficinas uma cartilha didática para uso como material de apoio contendo informações necessárias para futuras aplicações dos conhecimentos adquiridos. Além de auxiliar no desenvolvimento de soluções para problemas técnicos e sociais do município, também foi possível através da relação entre conhecimentos acadêmico-científicos e populares um significativo avanço qualitativo na formação do acadêmico

    Taxonomy for Industrial Cluster Decarbonization: An Analysis for the Italian Hard-to-Abate Industry

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    The share of industry in final global energy consumption was more than 30% in 2020, of which, the hard-to-abate sectors accounted for almost 60% of total final consumption in industry. Similarly, in Europe, industry accounts for around 25% of final energy consumption. In order to reduce the impact of industry in energy consumption and greenhouse gas emissions, Europe has set many policies that support and regulate the sector, including pricing carbon emissions in a cap-and-trade scheme called the European Emission Trading Scheme (EU ETS). According to the EU ETS, in 2021 the verified emissions of all stationary installations were around 1.3 billion tons of carbon dioxide equivalent emissions. In 2021, the total allocated allowances amounted to around 1 billion tons of carbon dioxide equivalent emissions, half of which were freely allocated. After reviewing the existing modeling approaches for industrial clusters and the available datasets, and assessing the energy consumption and carbon dioxide emissions at plant level using a geographical information system approach (GIS), a taxonomy for industrial cluster decarbonization was introduced. This taxonomy shows that describing industry as sets of clustered installations rather than based on the conventional sectoral economic classification provides more insights into energy transition. First, the cluster description provides a more accurate techno-economic assessment based on a finer characterization of economies of scale compared to traditional energy systems models. Second, the industrial clustering approach may more realistically show the feasibility, in addition to the costs and benefits from coupling industry with transport (e.g., industrial fleets and logistics) or buildings (e.g., city scale), due to a more detailed representation of the energy sources and sinks

    Gene expression profiling of Mycobacterium avium subsp. paratuberculosis in simulated multi-stress conditions and within THP-1 cells reveals a new kind of interactive intramacrophage behaviour

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    Recent studies have identified in Mycobacterium avium subsp. paratuberculosis (MAP), already known as a pathogen in ruminants, a potential zoonotic agent of some autoimmune diseases in humans. Therefore, considering the possible risk for public health, it is necessary a thorough understanding of MAP's gene expression during infection of human host as well as the identification of its immunogenic and/or virulence factors for the development of appropriate diagnostic and therapeutic tools.In order to characterize MAP's transcriptome during macrophage infection, we analyzed for the first time the whole gene expression of a human derived strain of MAP in simulated intraphagosomal conditions and after intracellular infection of the human macrophage cell line THP-1 by using the DNA-microarray technology. Results showed that MAP shifts its transcriptome to an adaptive metabolism for an anoxic environment and nutrient starvation. It up-regulates several response factors to oxidative stress or intracellular conditions and allows, in terms of transcription, a passive surface peptidoglycan spoliation within the macrophage along with an intensification of the anabolic activity for lipidic membrane structures.These results indicate a possible interactive system between MAP and its host cell based on the internal mimicry unlike other intracellular pathogens, bringing new hypothesis in the virulence and pathogenicity of MAP and its importance in human health

    Variabilità spazio-temporale della microalga <i>Chrysophaeum taylorii</i> Lewis &amp; Bryan lungo le coste nord-orientali della Sardegna = Spatio-temporal variabilty of the microalga <i>Chrysophaeum taylorii</i> Lewis &amp; Bryan along North-Eastern Sardinian coasts

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    In the summer months of 2010 the cell density of the alien benthic microalga Chrysophaeum taylorii Lewis &amp; Bryan (Pelagophyceae) was assessed on hard benthic substrates in sixteen study sites along the north-eastern coast of Sardinia in order to obtain useful information on spatial and temporal variations of the species in the area during summer

    The close relationship between the Golgi trafficking machinery and protein glycosylation

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    La glicosilazione è la più comune modifica post-traduzionale delle proteine; media la loro corretta piegatura e stabilità, nonché il loro trasporto attraverso il trasporto secretorio. I cambiamenti nei glicani legati all'N e all'O sono stati associati a molteplici condizioni patologiche tra cui disturbi congeniti della glicosilazione, malattie infiammatorie e cancro. La glicosilazione della glicoproteina al Golgi coinvolge l'azione coordinata di centinaia di glicosiltransferasi e glicosidasi, che vengono mantenute nella posizione corretta attraverso il traffico di vescicole retrograde tra le cisterne di Golgi. In questa recensione, descriviamo il macchinario molecolare coinvolto nel traffico di vescicole e nel tethering presso l'apparato di Golgi e gli effetti delle mutazioni nel contesto della biosintesi dei glicani e delle malattie umane.Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases

    Natural radioactivity in Sardinian granite dimension stones

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    http://www.fe.infn.it/u/mantovani/CV/Proceedings/Puccini_10b.pd
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