AN ANALYSIS OF THE INFLUENCE OF THE TEXTILE MATERIAL DOUBLING PROCESS BY THERMOFUSING ON VAPOR PERMEABILITY

To confer shape and volume parameters, to ensure dimensional stability of surfaces and contours, some parts of clothing are doubled using the process of thermofusion with certain woven or nonwoven chemicalized materials. A priority in the work of producers of fabrics and textiles is to ensure comfort parameters and functions of apparel products are met and respected. Clothing products should ensure optimum insulation, air permeability, moisture absorption and transfer in order to give the wearer wellbeing and safety. In this paper we propose to analyze the influence of the technological process of doubling on the vapour permeability of the doubled assembly, compared with the permeability of the non-doubled material. As materials made of natural fibers are increasingly required, we focused on two natural fiber fabrics – 100% linen and 100% cotton - and a mixed natural fiber material – 64% linen, 34% viscose and 2% elastane. They were each doubled using thermofusion with woven or nonwoven chemicalized materials composed of wool mixed with polyamide. Laboratory measurements allow us to conclude to what extent the vapor permeability of the thermofused assemblies is influenced

FOOTWEAR DIVERSIFICATION BY TYPIFICATION OF COMPONENT PARTS

Diversification of a footwear product, constructively designed in a basic model, can be assured by putting into practice several diversification criteria. With this respect, the paper presents the results of the research on the diversification of a footwear product by typification of component parts. Thus, starting from a leisure time model of men shoe with vamp and whole quarters, diversification was made by detailing the basic patterns of the uppers. The detailing of the basic drawing of the uppers was made so that the outer contour of the two parts (the vamp and quarter) remains unchanged even in the case of patterns consisting of several components. Also, the vamp-quarter merging line will keep its position on the shoe last, its length, and its configuration unchanged. Under these circumstances, by detailing the vamp and the quarter, several variants of these fragmented parts resulted, which are considered typified parts. The use of typified parts for uppers will ensure the diversification of the basic model. The analysis of the resulting model variants led to highlighting the influence of the number of component parts of the uppers and of the set area on the usage index of the leather surface and the specific consumption at cutting

Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer

The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker

Evidence for the tongue of ionization under northward interplanetary magnetic field conditions

[1] The activities of the International Ionospheric Tomography Community open up new possibilities of simultaneously imaging the large-scale spatial structure of the ionosphere in different longitude sectors. In the study, tomography receiver chains in Scandinavia and Greenland were used to provide a wide view of the plasma density structure in the winter, magnetic postnoon sector under conditions of stable, positive interplanetary magnetic field B z component. The spatial distributions of the plasma are discussed in light of a high-latitude plasma convection pattern pertinent to the conditions, which is supported by DMSP flow measurements. The observations are consistent with a tongue of dayside photoionization being drawn antisunward by the convection pattern to form an arc of enhanced plasma density around the periphery of the polar cap

Modelling the tongue-of-ionisation using CTIP with SuperDARN electric potential input: verification by radiotomography

Electric potential patterns obtained by the SuperDARN radar network are used as input to the Coupled Thermosphere-Ionosphere-Plasmasphere model, in an attempt to improve the modelling of the spatial distribution of the ionospheric plasma at high latitudes. Two case studies are considered, one under conditions of stable IMF <I>B<sub>z</sub></I> negative and the other under stable IMF <I>B<sub>z</sub></I> positive. The modelled plasma distributions are compared with sets of well-established tomographic reconstructions, which have been interpreted previously in multi-instrument studies. For IMF <I>B<sub>z</sub></I> negative both the model and observations show a tongue-of-ionisation on the nightside, with good agreement between the electron density and location of the tongue. Under <I>B<sub>z</sub></I> positive, the SuperDARN input allows the model to reproduce a spatial plasma distribution akin to that observed. In this case plasma, unable to penetrate the polar cap boundary into the polar cap, is drawn by the convective flow in a tongue-of-ionisation around the periphery of the polar cap

Comparison of hypofractionation and standard fractionation for post-prostatectomy salvage radiotherapy in patients with persistent PSA: single institution experience

Background: Hypofractionated post-prostatectomy radiotherapy is emerging practice, however with no randomized evidence so far to support it’s use. Additionally, patients with persistent PSA after prostatectomy may have aggressive disease and respond less well on standard salvage treatment. Herein we report outcomes for conventionally fractionated (CFR) and hypofractionated radiotherapy (HFR) in patients with persistent postprostatectomy PSA who received salvage radiotherapy to prostate bed. Methods: Single institution retrospective chart review was performed after Institutional Review Board approval. Between May 2012 and December 2016, 147 patients received salvage postprostatectomy radiotherapy. PSA failure-free and metastasis-free survival were calculated using Kaplan–Meier method. Cox regression analysis was performed to test association of fractionation regimen and other clinical factors with treatment outcomes. Early and late toxicity was assessed using Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Results: Sixty-nine patients who had persistent PSA (≥ 0.1 ng/mL) after prostatectomy were identified. Median follow-up was 67 months (95% CI 58–106 months, range, 8–106 months). Thirty-six patients (52.2%) received CFR, 66 Gy in 33 fractions, 2 Gy per fraction, and 33 patients (47.8%) received HFR, 52.5 Gy in 20 fractions, 2.63 Gy per fraction. Forty-seven (68%) patients received androgen deprivation therapy (ADT). 5-year PSA failure- and metastasis-free survival rate was 56.9% and 76.9%, respectively. Thirty patients (43%) experienced biochemical failure after salvage radiotherapy and 16 patients (23%) experienced metastatic relapse. Nine patients (13%) developed metastatic castration-resistant disease and died of advanced prostate cancer. Median PSA failure-free survival was 72 months (95% CI; 41–72 months), while median metastasis-free survival was not reached. Patients in HFR group were more likely to experience shorter PSA failure-free survival when compared to CFR group (HR 2.2; 95% CI 1.0–4.6, p = 0.04). On univariate analysis, factors significantly associated with PSA failure-free survival were radiotherapy schedule (CFR vs HFR, HR 2.2, 95% CI 1.0–4.6, p = 0.04), first postoperative PSA (HR 1.02, 95% CI 1.0–1.04, p = 0.03), and concomitant ADT (HR 3.3, 95% CI 1.2–8.6, p = 0.02). On multivariate analysis, factors significantly associated with PSA failure-free survival were radiotherapy schedule (HR 3.04, 95% CI 1.37–6.74, p = 0.006) and concomitant ADT (HR 4.41, 95% CI 1.6–12.12, p = 0.004). On univariate analysis, factors significantly associated with metastasis-free survival were the first postoperative PSA (HR 1.07, 95% CI 1.03–1.12, p = 0.002), seminal vesicle involvement (HR 3.48, 95% CI 1.26–9.6,p = 0.02), extracapsular extension (HR 7.02, 95% CI 1.96–25.07, p = 0.003), and surgical margin status (HR 2.86, 95% CI 1.03–7.97, p = 0.04). The first postoperative PSA (HR 1.04, 95% CI 1.00–1.08, p = 0.02) and extracapsular extension (HR 4.24, 95% CI 1.08–16.55, p = 0.04) remained significantly associated with metastasis-free survival on multivariate analysis. Three patients in CFR arm (8%) experienced late genitourinary grade 3 toxicity. Conclusions: In our experience, commonly used hypofractionated radiotherapy regimen was associated with lower biochemical control compared to standard fractionation in patients with persistent PSA receiving salvage radiotherapy. Reason for this might be lower biological dose in HFR compared to CFR group. However, this observation is limited due to baseline imbalances in ADT use, ADT duration and Grade Group distribution between two radiotherapy cohorts. In patients with persistent PSA post-prostatectomy, the first postoperative PSA is an independent risk factor for treatment failure. Additional studies are needed to corroborate our observations