N-[(E)-Quinoxalin-2-ylmethyl­idene]-1H-indazol-5-amine

In the title mol­ecule, C16H11N5, the mean planes of the quinoxaline and indazole fragments form a dihedral angle of 10.62 (5)°. In the crystal, weak inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into zigzag chains extending in the [001] direction. The crystal packing also exhibits π–π inter­actions [centroid–centroid distances of 3.7080 (2) and 3.8220 (5) Å], which form stacks of the mol­ecules parallel to the a axis

(Z)-2-Amino-3-[(E)-benzyl­ideneamino]but-2-enedinitrile

The asymmetric unit of the title compound, C11H8N4, contains two independent mol­ecules. In the crystal structure, inter­molecular N—H⋯N hydrogen bonds link mol­ecules into ribbons extended in the [100] direction

N,N′-Bis[(E)-quinoxalin-2-ylmethyl­idene]­ethane-1,2-diamine

In the mol­ecule of the title compound, C20H16N6, the central C—C bond lies on a crystallographic inversion centre. The quinoxalidine ring is nearly planar, with a maximum deviation of 0.021 (2) Å from the mean plane. The crystal structure is stabilized by inter­molecular C—H⋯N inter­actions, leading to the formation of a layer-like structure, which extends along the a axis

Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

Nuclear lamin filaments and associated proteins form a nucleoskeletal (“lamina”) network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans. Lamina defects cause human disease (“laminopathies”) and are linked to aging. Barrier-to-autointegration factor (BAF) is a mobile and essential component of the nuclear lamina that binds directly to histones, lamins and LEM-domain proteins, including the inner nuclear membrane protein emerin, and has roles in chromatin structure, mitosis and gene regulation. To understand BAF's mechanisms of action, BAF associated proteins were affinity-purified from HeLa cell nuclear lysates using BAF-conjugated beads, and identified by tandem mass spectrometry or independently identified and quantified using the iTRAQ method. We recovered A- and B-type lamins and core histones, all known to bind BAF directly, plus four human transcription factors (Requiem, NonO, p15, LEDGF), disease-linked proteins (e.g., Huntingtin, Treacle) and several proteins and enzymes that regulate chromatin. Association with endogenous BAF was independently validated by co-immunoprecipitation from HeLa cells for seven candidates including Requiem, poly(ADP-ribose) polymerase 1 (PARP1), retinoblastoma binding protein 4 (RBBP4), damage-specific DNA binding protein 1 (DDB1) and DDB2. Interestingly, endogenous BAF and emerin each associated with DDB2 and CUL4A in a UV- and time-dependent manner, suggesting BAF and emerin have dynamic roles in genome integrity and might help couple DNA damage responses to the nuclear lamina network. We conclude this proteome is a rich source of candidate partners for BAF and potentially also A- and B-type lamins, which may reveal how chromatin regulation and genome integrity are linked to nuclear structure

Myctophids in the Arabian Sea and its Systematics

The northern Arabian Sea is the habitat of large mid-water fish stocks (Gjøsæter, 1984). These stocks reside all along the outer edges of the coastal zone of the Arabian Peninsula, off Pakistan, and the Gulf of Oman. Doubtless there are also sizeable stocks off Somalia and northern India. Off the Arabian Peninsula and in the Gulf of Oman these stocks are dominated by myctophids, mostly by Benthosema pterotum, although Benthosema fibulatum, Diaphus arabicus (Kinzer et al.1993), Myctophum spinosum, and Symbolophorus evermanni are occasional large contributors. Possibly the B. pterotum population is the largest, localized fish stock in the world, amounting to 100 million tons! It has been suggested that this very large stock of the one species derives from the very small stocks of all other fish; for some reason B. pterotum and other myctophids are the competitive dominants (GLOBEC, 1993)

Transition metal complexes of quinoxaline based Schiff base ligands: Synthesis,characterization and catalytic activity study

Schiff base complexes of transition metal ions have played a significant role in coordination chemistry.The convenient route of synthesis and thermal stability of Schiff base complexes have contributed significantly for their possible applications in catalysis,biology,medicine and photonics.Significant variations in cataltytic activity with structure and type are observed for these complexes.The thesis deals with synthsis and characterization of transition metal complexes of quinoxaline based Schiff base ligands and their catalytic activity study.The Schiff bases synthesized in the present study are quinoxaline-2-carboxalidine-2-amino-5-methylphenol,3-hydroxyquinoxaline-2-carboxalidine-2-amino-5-methylphenol,quinoxaline-2-aminothiophenol.They provide great structural diversity during complexation.To the best of our knowledge, the transition metal complexes of quinoxaline based Schiff bases are poorly utilised in academic and industrial research.Dept.of Applied Chemistry,Cochin University of Science and Technolog

A study on the effectiveness of formal and teacher initiated student mentoring in B-Schools in Kerala

School of Management Studies,Cochin University of Science and Technolog

Oxidation kinetics of nickel nano crystallites obtained by controlled thermolysis of diaquabis(ethylenediamine) nickel(II) nitrate

The metal complex, [Ni(en)2(H2O)2](NO3)2 (en = ethylenediamine), was decomposed in a static furnace at 200 C by autogenous decomposition to obtain phase pure metallic nickel nanocrystallites. The nickel metal thus obtained was studied by XRD, IR spectra, SEM and CHN analysis. The nickel crystallites are in the nanometer range as indicated by XRD studies. The IR spectral studies and CHN analyses show that the surface is covered with a nitrogen containing species. Thermogravimetric mass gain shows that the product purity is high (93%). The formed nickel is stable and resistant to oxidation up to 350 C probably due to the coverage of nitrogen containing species. Activation energy for the oxidation of the prepared nickel nanocrystallites was determined by non-isothermal methods and was found to depend on the conversion ratio. The oxidation kinetics of the nickel crystallites obeyed a Johnson–Mehl–Avrami mechanism probably due to the special morphology and crystallite strain present on the metal

(Z)-2-Amino-3-[(E )-benzylideneamino]but-2-enedinitrile

The asymmetric unit of the title compound, C11H8N4, contains two independent molecules. In the crystal structure, intermolecular N—H.....N hydrogen bonds link molecules into ribbons extended in the [100] directio