428 research outputs found

    Commentary: Tax-Exemption for Hospitals: Towards an Understanding of Community Benefit

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    KNEE POWER IN LOW BACK PAIN SUBJECTS DURING RUNNING

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    The purpose of this study was to examine lower extremity shock absorption between runners with and without low back pain. We compared data from three groups based on low back pain status: current low back pain, resolved pain after a single bout of low back pain and runners who never had low back pain (CTRL). All subjects ran at least 20 km per week and ran on a force treadmill at 3.8 mā€¢s-1 while kinematic and kinetic data were collected. Work was determined from joint power histories during the shock attenuation portion of the stance phase. Individuals with a history of low back pain exhibited less peak knee negative power and negative work suggesting that they exhibited decreased eccentric muscle activity during foot-ground impact. The results of this study suggest that decreased eccentric activity of the muscles crossing the knee joint is associated with individuals who have low back pain and, to a lesser extent, with those who have residual low back pain. We suggest that the decreased eccentric activity can result in the footground impact shock wave moving through the lower extremity with little attenuation to the low back region

    Atomization and Dispersion of a Liquid Jet Injected Into a Crossflow of Air

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    In recent years, environmental regulations have become more stringent, requiring lower emissions of mainly nitrogen oxides (NOx), as well as carbon monoxide (CO) and unburned hydrocarbons (UHC). These regulations have forced the gas turbine industry to examine non-conventional combustion strategies, such as the lean burn approach. The reasoning behind operating under lean conditions is to maintain the temperature of combustion near and below temperatures required for the formation of thermal nitric oxide (NO). To be successful, however, the lean processes require careful preparation of the fuel/air mixture to preclude formation of either locally rich reaction zones, which may give rise to NO formation, or locally lean reaction zones, which may give rise to inefficient fuel processing. As a result fuel preparation is crucial to the development and success of new aeroengine combustor technologies. A key element of the fuel preparation process is the fuel nozzle. As nozzle technologies have developed, airblast atomization has been adopted for both industrial and aircraft gas turbine applications. However, the majority of the work to date has focused on prefilming nozzles, which despite their complexity and high cost have become an industry standard for conventional combustion strategies. It is likely that the new strategies required to meet future emissions goals will utilize novel fuel injector approaches, such as radial injection. This thesis proposes and demonstrates an experiment to examine, on a mechanistic level (i.e., the physics of the action), the processes associated with the atomization, evaporation, and dispersion of a liquid jet introduced, from a radial, plain-jet airblast injector, into a crossflow of air. This understanding requires the knowledge not only of what factors influence atomization, but also the underlying mechanism associated with liquid breakup and dispersion. The experimental data acquired identify conditions and geometries for improved performance of radial airblast injectors

    Exploring the Demand for Retirement Planning Advice: The Role of Financial Literacy

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    This research extends previous literature on the relationship between financial literacy and financial advice seeking in three ways: (1) we examine financial planner use specifically within the context of retirement planning, (2) we incorporate Hustonā€™s (2010) framework of financial literacy, and (3) we use longitudinal data to investigate the initiation, maintenance, and termination of financial planner use. Results from the 2010 and 2012 National Longitudinal Survey of Youth 1979 (NLSY79) show a positive association between the components of financial literacy and financial planner use for retirement planning

    Household Use of Financial Planners: Measurement Considerations for Researchers

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    Citation: Heckman, Stuart J. and Seay, Martin C and Kim, Kyoung Tae and Letkiewicz, Jodi, Household Use of Financial Planners: Measurement Considerations for Researchers (November 2, 2016). Financial Services Review, Vol. 25, p. 427-446, 2016.Using the Certified Financial Planner (CFP) Boardā€™s definition of financial planning, this paper evaluates the validity of the measures of financial planner use in publicly available datasets. A review of Financial Services Review, Journal of Personal Finance, Journal of Financial Planning, Journal of Family and Economic Issues, Journal of Consumer Affairs, and Journal of Financial Counseling and Planning identified seven datasets that were commonly used to investigate financial planner use. Of these, the two most promising measures were found in the Survey of Consumer Finances and the National Longitudinal Study of Youth (1979). However, an evaluation of these measures raises significant concerns related to their validity. This article critically evaluates these measures and provides insights into the development of better measures of financial planner use for the future

    The Sonora Brown Dwarf Atmosphere and Evolution Models. I. Model Description and Application to Cloudless Atmospheres in Rainout Chemical Equilibrium

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    We present a new generation of substellar atmosphere and evolution models , appropriate for application to studies of L-, T-, and Y-type brown dwarfs and self-luminous extrasolar planets. The models describe the expected temperature-pressure proļ¬les and emergent spectra of atmospheres in radiative-convective equilibrium with effective temperatures and gravities within the ranges ā‰¤ Teff ā‰¤ 2400 K and . These ranges encompass masses from about 0.5 to 85 Jupiter masses for a set of metallicities ([M/H] = āˆ’ 0.5 to + 0.5),C/O ratios (from 0.5 to 1.5 times that of solar), and ages. These models expand the diversity of model atmospheres currently available, notably to cooler effective temperatures and greater ranges in C/O. Notable improvements from past such models include updated opacities and atmospheric chemistry. Here we describe our modeling approach and present our initial tranche of models for cloudless, chemical equilibrium atmospheres. We compare the modeled spectra, photometry, and evolution to various data sets

    Rumen and Serum Metabolomes in Response to Endophyte-Infected Tall Fescue Seed and Isoflavone Supplementation in Beef Steers

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    Fescue toxicosis impacts beef cattle production via reductions in weight gain and muscle development. Isoflavone supplementation has displayed potential for mitigating these effects. The objective of the current study was to evaluate isoflavone supplementation with fescue seed consumption on rumen and serum metabolomes. Angus steers (n = 36) were allocated randomly in a 2 Ɨ 2 factorial arrangement of treatments including endophyte-infected (E+) or endophyte-free (Eāˆ’) tall fescue seed, with (P+) or without (Pāˆ’) isoflavones. Steers were provided a basal diet with fescue seed for 21 days, while isoflavones were orally administered daily. Following the trial, blood and rumen fluid were collected for metabolite analysis. Metabolites were extracted and then analyzed by UPLC-MS. The MAVEN program was implemented to identify metabolites for MetaboAnalyst 4.0 and SAS 9.4 statistical analysis. Seven differentially abundant metabolites were identified in serum by isoflavone treatment, and eleven metabolites in the rumen due to seed type (p \u3c 0.05). Pathways affected by treatments were related to amino acid and nucleic acid metabolism in both rumen fluid and serum (p \u3c 0.05). Therefore, metabolism was altered by fescue seed in the rumen; however, isoflavones altered metabolism systemically to potentially mitigate detrimental effects of seed and improve animal performance

    Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH receptor binding, and TRH responses in neurons of rat brainstem

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    We investigated the postnatal development of the thyrotropin-releasing hormone (TRH)-containing raphe system in the brainstem of neonatal rats. Postnatal changes in TRH expression in nucleus (n.) raphe obscurus (ROb) and n. raphe pallidus (RPa) were evaluated by in situ hybridization using an 35S-labeled oligonucleotide probe complementary to TRH precursor mRNA. TRH mRNA expression was low at birth [postnatal day 0 (P0)], but was clearly evident by P7 and increased from that time to reach sustained high levels from P14 to P28. Consistent with this postnatal increase in TRH expression, we found increases in the density of TRH-immunoreactive (IR) fibers, which are derived from ROb and RPa, in the hypoglossal nucleus (nXII). TRH-IR fibers in nXII were very sparse at P0, but increased markedly over the first 2 postnatal weeks. The change in TRH innervation of nXII was closely matched by concomitant increases in 3H-methyl-TRH binding in nXII; specific TRH binding increased from very low levels at birth to high levels of P14. Finally, we recorded intracellularly the electrophysiological responses to TRH of hypoglossal motoneurons (HMs; n = 42) of neonatal rats (P0- P21) in a brainstem slice preparation. The response of neonatal HMs to TRH, in contrast to adult HMs, was highly variable. In some neonatal HMs, even at P0, TRH caused a depolarization with a decrease in input conductance (GN) that was characteristic of the response of all adult HMs. However, in other neonatal HMs, TRH was either without effect or caused a slight depolarization with no apparent change in GN, responses that were unlike those of adult HMs. A response was considered typical (i.e., ā€œadult-likeā€) if GN decreased to < 85% of control. The percentage of cells responding in a typical manner increased progressively from 25% at P0-P2 to 100% after P11. In addition, we found that the density of TRH-sensitive current (normalized to cell capacitance) increased with postnatal age in HMs that responded in a typical manner, suggesting that expression of the TRH-sensitive conductance is also developmentally regulated. Together, these data indicate that the TRH raphe neuronal system of the rat brainstem is not fully mature at the time of birth but develops over the first few postnatal weeks. This was true of levels of TRH mRNA in caudal raphe nuclei, density of TRH-IR fibers and 3H-methyl-TRH binding in nXII, and also the manner and magnitude of electrophysiological responses of HMs to exogenously applied TRH

    Genome-Wide Identification, Classification, and Expression Analysis of Autophagy-Associated Gene Homologues in Rice (Oryza sativa L.)

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    Autophagy is an intracellular degradation process for recycling macromolecules and organelles. It plays important roles in plant development and in response to nutritional demand, stress, and senescence. Organisms from yeast to plants contain many autophagy-associated genes (ATG). In this study, we found that a total of 33 ATG homologues exist in the rice [Oryza sativa L. (Os)] genome, which were classified into 13 ATG subfamilies. Six of them are alternatively spliced genes. Evolutional analysis showed that expansion of 10 OsATG homologues occurred via segmental duplication events and that the occurrence of these OsATG homologues within each subfamily was asynchronous. The Ka/Ks ratios suggested purifying selection for four duplicated OsATG homologues and positive selection for two. Calculating the dates of the duplication events indicated that all duplication events might have occurred after the origin of the grasses, from 21.43 to 66.77 million years ago. Semi-quantitative RTā€“PCR analysis and mining the digital expression database of rice showed that all 33 OsATG homologues could be detected in at least one cell type of the various tissues under normal or stress growth conditions, but their expression was tightly regulated. The 10 duplicated genes showed expression divergence. The expression of most OsATG homologues was regulated by at least one treatment, including hormones, abiotic and biotic stresses, and nutrient limitation. The identification of OsATG homologues showing constitutive expression or responses to environmental stimuli provides new insights for in-depth characterization of selected genes of importance in rice
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