Genoviz Software Development Kit: Java tool kit for building genomics visualization applications

<p>Abstract</p> <p>Background</p> <p>Visualization software can expose previously undiscovered patterns in genomic data and advance biological science.</p> <p>Results</p> <p>The Genoviz Software Development Kit (SDK) is an open source, Java-based framework designed for rapid assembly of visualization software applications for genomics. The Genoviz SDK framework provides a mechanism for incorporating adaptive, dynamic zooming into applications, a desirable feature of genome viewers. Visualization capabilities of the Genoviz SDK include automated layout of features along genetic or genomic axes; support for user interactions with graphical elements (Glyphs) in a map; a variety of Glyph sub-classes that promote experimentation with new ways of representing data in graphical formats; and support for adaptive, semantic zooming, whereby objects change their appearance depending on zoom level and zooming rate adapts to the current scale. Freely available demonstration and production quality applications, including the Integrated Genome Browser, illustrate Genoviz SDK capabilities.</p> <p>Conclusion</p> <p>Separation between graphics components and genomic data models makes it easy for developers to add visualization capability to pre-existing applications or build new applications using third-party data models. Source code, documentation, sample applications, and tutorials are available at <url>http://genoviz.sourceforge.net/</url>.</p

Early and persistent ‘extreme delta brush’ in a patient with anti-NMDA receptor encephalitis

Since its original description in 2007, anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis associated with an ovarian teratoma is an increasingly recognized etiology of previously unexplained encephalopathy and encephalitis. Extreme delta brush (EDB) is a novel electroencephalogram (EEG) finding seen in many patients with anti-NMDAR encephalitis. The presence of this pattern is associated with a more prolonged illness, although the specificity of this pattern is unclear. Additionally, the frequency and sensitivity of EDB in anti-NMDAR encephalitis and its implications for outcome have yet to be determined. We report a patient with early evidence of extreme delta brush and persistence of this pattern 17.5 weeks later with little clinical improvement

Early and persistent \u27extreme delta brush\u27 in a patient with anti-NMDA receptor encephalitis

Since its original description in 2007, anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis associated with an ovarian teratoma is an increasingly recognized etiology of previously unexplained encephalopathy and encephalitis. Extreme delta brush (EDB) is a novel electroencephalogram (EEG) finding seen in many patients with anti-NMDAR encephalitis. The presence of this pattern is associated with a more prolonged illness, although the specificity of this pattern is unclear. Additionally, the frequency and sensitivity of EDB in anti-NMDAR encephalitis and its implications for outcome have yet to be determined. We report a patient with early evidence of extreme delta brush and persistence of this pattern 17.5. weeks later with little clinical improvement. © 2014 The Authors

Évaluation de la performance de la génération d'idées à l'aide d'utilisateurs avant-gardistes, dans le cadre du développement de nouveaux produits

International audienceLes techniques traditionnelles de génération d'idées, fondées sur les contributions de clients, consistent généralement à collecter de l'information sur des besoins en nouveaux produits à partir d'un ensemble de clients typiques ou alors choisis de façon aléatoire. L'approche faisant appel aux « utilisateurs pionniers » s'en démarque. Elle consiste à collecter des informations sur les besoins et les solutions émanant d'utilisateurs à la pointe des nouveautés sur le marché cible, ainsi qu'à partir de clients d'autres marchés rencontrant le même type de problématique mais plus accentuée. Cet article fait part d'une expérimentation naturelle conduite dans l'entreprise 3M, sur l'impact du processus de génération d'idées à l'aide d'utilisateurs pionniers (UP) comparé à des méthodes plus traditionnelles. 3M est renommé pour ses capacités d'innovation, nous trouvons d'ailleurs que le processus UP semble améliorer ces capacités. Les ventes annuelles du produit moyen financé généré par le projet UP chez 3M sont projetées de façon conservatrice à 146 millions de dollars après cinq ans (plus de huit fois supérieures aux prévisions de ventes des idées de produit générées à partir du projet « traditionnel »). Il est projeté que chaque projet UP financé créera une nouvelle gamme majeure de produit pour une division particulière de 3M. Il en découle que les divisions qui financent des idées de projet UP projettent leur meilleur taux de génération de gamme majeure de produit depuis les cinquante dernières années

QTc-prolongation in posterior circulation stroke

BACKGROUND AND PURPOSE: To evaluate the relationship between infarct location and QTc-prolongation in patients with posterior circulation strokes. METHODS: Admission electrocardiograms (ECG) of 131 patients among a prospective sample of 407 consecutive adult patients in the New England Medical Center Posterior Circulation Registry were retrospectively analyzed. The QT interval (ms) was measured and corrected using Bazett\u27s formula (QTcBazett) as well as linear regression functions (QTcLinear). QTcBazett \u3e 440 ms and QTcLinear \u3e /= 450 ms for men ( \u3e /=460 ms for women) were considered prolonged. Multivariable linear and logistic regression analyses were used to identify independent predictors of the QTc. RESULTS: Overall, 34% of patients had a prolonged QTcBazett and 7% had a prolonged QTcLinear noted on the admission ECG. There was a significant association between temporal lobe infarction and QTcBazett and QTcLinear (p \u3c 0.001 for both) in multivariable linear regression analyses adjusting for demographics, ECG parameters, and preadmission medication use. In multivariable logistic regression analysis, temporal lobe infarction emerged as an independent predictor of prolonged QTcBazett (p = 0.009) and QTcLinear (p = 0.008), respectively. Sensitivity analyses excluding patients with transient ischemic attack yielded similar results. Exploratory analyses indicated that patients with temporal lobe infarction had worse functional 30-day outcomes in multivariable logistic regression (p = 0.022). However, there was no significant association between QTc and 30-day functional outcome. CONCLUSIONS: QTc-prolongation is common after posterior circulation stroke and associated with temporal lobe infarction. Prospective studies are needed to confirm these preliminary findings and to examine potential long-term consequences

Business Models Innovation through New Customer Roles: A Design-Driven Case Study

Business models as relational devices governing transactions with the customers and stakeholders identify new rules of customer engagement and their impact on business model innovations in design-intensive industries. These industries, framed as the locus of "cultural innovation", see the customer as a product 'sense giver'. In this setting, new customer roles are explored through a case study based on a fast-growing company operating in the furniture sector. The case study highlights three main customer roles that impact business models: (i) the customer as a market bridge; (ii) the customer context as a company "showroom,"; (iii) the customer as an external company design lab