Neural precursor cells tune striatal connectivity through the release of IGFBPL1

The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity

Prefazione

Il volume ha accompagnato una esposizione sulla vita e le opere di Giuseppe Pellizza ideata, per il centenario della morte dell'artista, in collaborazione coll'Istituto di Cultura Italiano di New York e che dopo New York ha fatto tappa anche a Londra e Torton

L'Autoritat del sistema clàssic

Conferència d'Aurora Scotti, arquitecte i professora titular d'Història de l'Arquitectura al Politecnico de Milà, presentada per Josep Mª Rovira, Director del Curs CUIMP

Giuseppe Pellizza da Volpedo. Il taccuino n.10. Paesaggi e figure

none1A. ScottiScotti, Auror