Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru

The objective of this study was to determine the etiology of febrile illnesses among patients from October 1, 1993 through September 30, 1999, in the urban community of Iquitos in the Amazon River Basin of Peru. Epidemiological and clinical data as well as blood samples were obtained from consenting patients at hospitals, health clinics and private residences. Samples were tested for arboviruses in cell cultures and for IgM and IgG antibodies by ELISA. Blood smears were examined for malaria, and sera were tested for antibodies to Leptospira spp. by ELISA and microscopic agglutination. Among 6,607 febrile patients studied, dengue viruses caused 14.6% of the cases, and Venezuelan equine encephalitis virus caused 2.5%, Oropouche virus 1.0%, Mayaro virus 0.4%, and other arboviruses caused 0.2% of the cases. Also, 22.9% of 4,844 patients tested were positive for malaria, and of 400 samples tested, 9% had evidence of acute leptospirosis. Although the study was not designed to assess the importance of these pathogens as a cause of human morbidity in the total population, these results indicate that arboviruses, leptospirosis, and malaria were the cause of approximately 50% of the febrile cases. Although the arboviruses that were diagnosed can produce asymptomatic infections, our findings increased the overall understanding of the relative health burden of these infections, as well as baseline knowledge needed for designing and implementing further studies to better assess the health impact and threat of these pathogens in the Amazon Basin of Peru

Human impacts on suspended sediment and turbidity in the River Murray, South Eastern Australia: Multiple lines of evidence

European settlement has led to increased loads of fine suspended sediment (SS) entering the River Murray, Australia's largest, and arguably, most important river. The River Murray's anthropogenic sediment history can be divided into four periods with varying source areas, sediment loads, and seasonal patterns. The Aboriginal period (before 1840) was characterized by clear water at summer low‐flows in the River Murray and its southern tributaries, with more sediment coming from the northern catchment than the southern, and the Darling River being turbid at all flows. There is little evidence that Aboriginal burning resulted in any measurable increase in SS. SS loads peaked in the 1870s and 1880s (the gold and gully period, 1850–1930) as valley floors were incised by gullies (mostly in northern tributaries), and gold sluicing flushed huge amounts of sludge into southern tributaries. Sedimentation in wetlands and on floodplains increased by 2–10 times in this period, and the biota in wetlands switched from clear water to turbid water communities. In the hiatus period (1930–1960) sediment supply from gullies and gold mining waned and low flow SS concentrations returned to low levels. Dam construction through the 1960s and 1970s (the regulation period, 1960 on) disconnected the River Murray from catchment derived sediment. Despite this, SS levels increased again: now largely derived from instream sources including bank erosion from long duration summer irrigation flows, the spread of bottom‐feeding carp (Cyprinus carpio), and wave erosion from boats. Erosion switched from winter to summer dominated. Significant investment in securing water for the environment in the Murray‐Darling Basin could be complemented by addressing in‐channel sediment sources in the River Murray itself to reduce turbidity. Overall, European era SS concentrations remain relatively low with small sediment delivery to the ocean (0.1 Mt per annum), despite high catchment erosion rates. This is due to poor sediment delivery efficiency through the low‐gradient landscape