An Analysis of Adult Educators’ Experiences with Professional Development Activities

This study was designed to explore Adult Basic Education (ABE), Adult Secondary Education (ASE), and English as a Second Language (ESL) teachers’ experiences with professional development. The study sought to determine whether adult learning principles were evident in the facilitation of professional development activities. The study instrument was administered online to members of the Coalition on Adult Basic Education (COABE), with a total of n=348 respondents to the survey. The survey consisted of demographic questions, questions related to professional development experiences, and an open response question. The majority of respondents were teachers/instructors (n=232, 66.7%), held a master’s degree (n=187, 54.4%), and did not have adult education certification/licensure (n=205, 59.1%). Exploratory factor analysis (EFA) was utilized to identify adult learning principles that were perceived by ABE, ASE, and ESL teachers who attended professional development. Seven factors emerged to explain 67.11% of the total variance among 32 items on the instrument. The first factor in the exploratory factor analysis indicated that during professional development, ABE, ASE, and ESL teachers learned new skills and strategies for working with adult learners that were applicable to their classroom instruction. The other factors had fewer items and were less defined. To describe how the learning environment impacted ABE, ASE, and ESL teachers’ professional development experiences, a one-way between-groups analysis of variance (ANOVA) was conducted. Results indicated no statistically significant difference among the groups. To compare perceptions of facilitator skills and abilities that impacted ABE, ASE, and ESL teachers’ professional development experiences, a one-way between-groups analysis of variance (ANOVA) was used. Data analysis indicated differences existed between ASE and ESL groups on two items

Pathological changes within the cerebral vasculature in Alzheimer's disease:New perspectives

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the contribution of cerebral amyloid angiopathy and non‐amyloid small vessel disease in AD, and the accompanying changes to the density, maintenance and remodelling of vessels (including alterations to the composition and function of the cerebrovascular basement membrane). We consider how abnormalities of the constituent cells of the neurovascular unit – particularly of endothelial cells and pericytes – and impairment of the blood‐brain barrier (BBB) impact on the pathogenesis of AD. We also discuss how changes to the cerebral vasculature are likely to impair Aβ clearance – both intra‐periarteriolar drainage (IPAD) and transport of Aβ peptides across the BBB, and how impaired neurovascular coupling and reduced blood flow in relation to metabolic demand increase amyloidogenic processing of APP and the production of Aβ. We review the vasoactive properties of Aβ peptides themselves, and the probable bi‐directional relationship between vascular dysfunction and Aβ accumulation in AD. Lastly, we discuss recent methodological advances in transcriptomics and imaging that have provided novel insights into vascular changes in AD, and recent advances in assessment of the retina that allow in vivo detection of vascular changes in the early stages of AD

Evaluation of Voting with Form Dropout Techniques for Ballot Vote Counting

Vote counting accuracy has become a well-known issue in the vote collection process. Digital image processing techniques can be incorporated in the analysis of printed election ballots. Current image processing techniques in the vote collection process are heavily dependent on the anticipated, geometric positioning of the vote. These techniques don’t account for markings made outside of the requested field of input. Using various form dropout techniques, however, every mark on the form can be extracted and used by the machine to make an intelligent decision. Most methods will still miss a few marks and result in a few false alarms. This paper explores methods of voting between the results of the different mark extraction methods to improve recognition. To provide diversity a simple image subtraction technique is paired with a distance transform and a morphology based algorithm. The result has a higher detection rate and a lower false alarm rate

Blood flow analysis of the aortic arch using computational fluid dynamics in a coupled 3D-0D framework

Regions of the aortic arch affected by an aneurysm or dissection may require surgical intervention using vascular grafts, which includes a means of reperfusing the supra-aortic branch vessels, comprised of the left subclavian artery (LSA), left common carotid artery (LCCA) and brachiocephalic artery. Open surgical grafts are widely used in arch reconstruction yet the graft configuration which ensures optimal post-surgical perfusion is currently poorly understood. For example, peripheral organ ischaemia and post-operative malperfusion remain a concern. It is clear, therefore, that enhanced understanding of perfusion in patient-specific cases is critical to improving clinical practice and patient outcome

Perfusion optimisation for vascular grafts design used in the treatment of aortic disease

Regions of the aortic arch affected by an aneurysm or dissection may require surgical intervention using vascular grafts, which includes a means of re-perfusing the supra-aortic branch vessels. However, graft configuration to ensure optimal post-surgical perfusion is currently poorly understood. Therefore, enhanced understanding of perfusion in patient-specific cases is critical to improving clinical practice and patient outcomes. In this work, a combination of computational and experimental models of the aortic arch were created to investigate the pre-surgical haemodynamics of the aortic arch, using a coupled 3D-0D numerical framework to simulate a range of downstream conditions, both healthy and pathological

Fact sheet: Using a terrestrial ecosystem survey to estimate the historical density of ponderosa pine trees in northern Arizona

The Terrestrial Ecosystem Survey (TES) delineates ecosystems according to their climate, geology, soils, and potential natural vegetation (U.S. Forest Service 1986). Land managers and planners can use this information to help interpret site suitability for natural regeneration, reforestation, and revegetation potential as well as site suitability for road building, range and timber, range structures (watering sources), and other land uses. However, the TES can be used for other purposes as Ganey and Benoit (2002) demonstrated in their report about identifying potential habitat for Mexican spotted owl on national forest lands. Similarly, Bell and colleagues (2009) used the TES and its specific survey units (TESU) to analyze the characteristics of the Woolsey plots in northern Arizona - plots the Forest Service established in the early 1900s to examine tree regeneration. In our study, we identified historic ponderosa pine densities on various TES mapping units and then correlated our findings with what the TESU predicted we should find

Artemisia scoparia enhances adipocyte development and endocrine function in vitro and enhances insulin action in vivo

Background: Failure of adipocytes to expand during periods of energy excess can result in undesirable metabolic consequences such as ectopic fat accumulation and insulin resistance. Blinded screening studies have indicated that Artemisia scoparia (SCO) extracts can enhance adipocyte differentiation and lipid accumulation in cultured adipocytes. The present study tested the hypothesis that SCO treatment modulates fat cell development and function in vitro and insulin sensitivity in adipose tissue in vivo. Methods: In vitro experiments utilized a Gal4-PPARγ ligand binding domain (LBD) fusion protein-luciferase reporter assay to examine PPARγ activation. To investigate the ability of SCO to modulate adipogenesis and mature fat cell function in 3T3-L1 cells, neutral lipid accumulation, gene expression, and protein secretion were measured by Oil Red O staining, qRT-PCR, and immunoblotting, respectively. For the in vivo experiments, diet-induced obese (DIO) C57BL/6J mice were fed a high-fat diet (HFD) or HFD containing 1% w/w SCO for four weeks. Body weight and composition, food intake, and fasting glucose and insulin levels were measured. Phospho-activation and expression of insulin-sensitizing proteins in epididymal adipose tissue (eWAT) were measured by immunoblotting. Results: Ethanolic extracts of A. scoparia significantly activated the PPARγ LBD and enhanced lipid accumulation in differentiating 3T3-L1 cells. SCO increased the transcription of several PPARγ target genes in differentiating 3T3-L1 cells and rescued the negative effects of tumor necrosis factor α on production and secretion of adiponectin and monocyte chemoattractant protein-1 in fully differentiated fat cells. DIO mice treated with SCO had elevated adiponectin levels and increased phosphorylation of AMPKα in eWAT when compared to control mice. In SCO-treated mice, these changes were also associated with decreased fasting insulin and glucose levels. Conclusion: SCO has metabolically beneficial effects on adipocytes in vitro and adipose tissue in vivo, highlighting its potential as a metabolically favorable botanical supplement. © 2014 Richard et al

Mojave Applied Ecology Notes Summer 2011

Thoughts on fire possibilities on Mount Charleston, estimating historical densities of Ponderosa pine in northern AZ, over-understory changes in the Spring Mountains, seeding effectiveness in Red Rock Canyon, workshop announcements

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Long-Term Preservation of Cones and Improvement in Visual Function Following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis Caused by Guanylate Cyclase-1 Deficiency

Leber congenital amaurosis (LCA) is a severe retinal dystrophy manifesting from early infancy as poor vision or blindness. Loss-of-function mutations in GUCY2D cause LCA1 and are one of the most common causes of LCA, accounting for 20% of all cases. Human GUCY2D and mouse Gucy2e genes encode guanylate cyclase-1 (GC), which is responsible for restoring the dark state in photoreceptors after light exposure. The Glicy2e(-/-) mouse shows partially diminished rod function, but an absence of cone function before degeneration. Although the cones appear morphologically normal, they exhibit mislocalization of proteins involved in phototransduction. In this study we tested the efficacy of an rAAV2/8 vector containing the human rhodopsin kinase promoter and the human GUCY2D gene. Following subretinal delivery of the vector in Glicy2e(-/-) mice, GC1 protein was detected in the rod and cone outer segments, and in transduced areas of retina cone transducin was appropriately localized to cone outer segments. Moreover, we observed a dose-dependent restoration of rod and cone function and an improvement in visual behavior of the treated mice. Most importantly, cone preservation was observed in transduced areas up to 6 months post injection. To date, this is the most effective rescue of the Glicy2e(-/-) mouse model of LCA and we propose that a vector, similar to the one used in this study, could be suitable for use in a clinical trial of gene therapy for LCA1