2,700 research outputs found
Bi-Lipschitz geometry of weighted homogeneous surface singularities
We show that a weighted homogeneous complex surface singularity is metrically
conical (i.e., bi-Lipschitz equivalent to a metric cone) only if its two lowest
weights are equal. We also give an example of a pair of weighted homogeneous
complex surface singularities that are topologically equivalent but not
bi-Lipschitz equivalent.Comment: 5 pages. Added result that nonhomogeneous cyclic quotients are not
conica
Exercise with Blood Flow Restriction: An Updated Evidence-Based Approach for Enhanced Muscular Development
A growing body of evidence supports the use of moderate blood flow restriction (BFR) combined with low-load resistance exercise to enhance hypertrophic and strength responses in skeletal muscle. Research also suggests that BFR during low-workload aerobic exercise can result in small but significant morphological and strength gains, and BFR alone may attenuate atrophy during periods of unloading. While BFR appears to be beneficial for both clinical and athletic cohorts, there is currently no common consensus amongst scientists and practitioners regarding the best practice for implementing BFR methods. If BFR is not employed appropriately, there is a risk of injury to the participant. It is also important to understand how variations in the cuff application can affect the physiological responses and subsequent adaptation to BFR training. The optimal way to manipulate acute exercise variables, such as exercise type, load, volume, inter-set rest periods and training frequency, must also be considered prior to designing a BFR training programme. The purpose of this review is to provide an evidence-based approach to implementing BFR exercise. These guidelines could be useful for practitioners using BFR training in either clinical or athletic settings, or for researchers in the design of future studies investigating BFR exercise
Galois covers of the open p-adic disc
This paper investigates Galois branched covers of the open -adic disc and
their reductions to characteristic . Using the field of norms functor of
Fontaine and Wintenberger, we show that the special fiber of a Galois cover is
determined by arithmetic and geometric properties of the generic fiber and its
characteristic zero specializations. As applications, we derive a criterion for
good reduction in the abelian case, and give an arithmetic reformulation of the
local Oort Conjecture concerning the liftability of cyclic covers of germs of
curves.Comment: 19 pages; substantial organizational and expository changes; this is
the final version corresponding to the official publication in Manuscripta
Mathematica; abstract update
Electronic structure and ferroelectricity in SrBi2Ta2O9
The electronic structure of SrBi2Ta2O9 is investigated from first-principles,
within the local density approximation, using the full-potential linearized
augmented plane wave (LAPW) method. The results show that, besides the large
Ta(5d)-O(2p) hybridization which is a common feature of the ferroelectric
perovskites, there is an important hybridization between bismuth and oxygen
states. The underlying static potential for the ferroelectric distortion and
the primary source for ferroelectricity is investigated by a lattice-dynamics
study using the Frozen Phonon approach.Comment: 17 pages, 7 figures. Phys. Rev. B, in pres
Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes important for long-lasting forms of synaptic plasticity and memory storage. In the forebrain, the anchoring protein gravin recruits a signaling complex containing PKA, PKC, calmodulin, and PDE4D (phosphodiesterase 4D) to the β2-adrenergic receptor. Here, we show that mice lacking the α-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including β2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, both hippocampal β2-adrenergic receptor phosphorylation by PKA, and learning-induced activation of ERK in the CA1 region of the hippocampus are attenuated in mice lacking gravin-α. We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced β2-adrenergic receptor signaling and ERK activation in the hippocampus in vivo, thereby organizing molecular interactions between glutamatergic and noradrenergic signaling pathways for long-lasting synaptic plasticity, and memory storage
Spin-Orbit Effects on the Shapes of Cross Sections in the 90-Zr(p,p') Reaction at 160 MeV
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Effects of packaging on bone marrow discoloration in beef arm, rib, shoulder blade, and thoracic vertebra bones
Meat retailers have reported bone marrow
discoloration to be a problem, especially in
modified-atmosphere packages (MAP). To
evaluate causes of bone marrow discoloration
in different beef bones and packaging systems, 36 beef arm bones, ribs, shoulder blades, and thoracic vertebrae from USDA Select and Choice carcasses were obtained from a commercial abattoir, cut into 1-inch-thick sections at 4 days postmortem, and packaged into 1) polyvinyl chloride film (PVC) overwrap; 2) high-oxygen (80% O2, 20% CO2) MAP; or 3) ultra-low-oxygen (70% N2, 30% CO2) MAP. Packages were displayed under continuous fluorescent lighting for 4 days at 35.6°F. Ribs, shoulder blades, and thoracic vertebrae packaged in PVC and high-oxygen MAP developed undesirable gray or black discoloration during display. In ultra-low-oxygen MAP, mean visual-color scores were acceptable throughout display. The a* values (larger values equate to redder color) for ribs, shoulder blades, and thoracic vertebrae decreased (P<0.05) over time. Arm-bone marrow had less oxidation and dramatically less total iron and hemoglobin than did marrow from ribs and thoracic vertebrae. The much larger amounts of iron and hemoglobin in ribs and thoracic vertebrae likely correspond to marrow
discoloration. In summary, bone marrow
discoloration occurs in ribs, shoulder blades, and thoracic vertebrae packaged in PVC or high-oxygen MAP. Bones packaged in ultralow- oxygen MAP or arm bones packaged in
PVC or high-oxygen MAP had minimal oxidation
and discoloration
Stress Transmission through Three-Dimensional Ordered Granular Arrays
We measure the local contact forces at both the top and bottom boundaries of
three-dimensional face-centered-cubic and hexagonal-close-packed granular
crystals in response to an external force applied to a small area at the top
surface. Depending on the crystal structure, we find markedly different results
which can be understood in terms of force balance considerations in the
specific geometry of the crystal. Small amounts of disorder are found to create
additional structure at both the top and bottom surfaces.Comment: 9 pages including 9 figures (many in color) submitted to PR
On Love-type waves in a finitely deformed magnetoelastic layered half-space
In this paper, the propagation of Love-type waves in a homogeneously and finitely deformed layered half-space of an incompressible non-conducting magnetoelastic material in the presence of an initial uniform magnetic field is analyzed. The equations and boundary conditions governing linearized incremental motions superimposed on an underlying deformation and magnetic field for a magnetoelastic material are summarized and then specialized to a form appropriate for the study of Love-type waves in a layered half-space. The wave propagation problem is then analyzed for different directions of the initial magnetic field for two different magnetoelastic energy functions, which are generalizations of the standard neo-Hookean and Mooney–Rivlin elasticity models. The resulting wave speed characteristics in general depend significantly on the initial magnetic field as well as on the initial finite deformation, and the results are illustrated graphically for different combinations of these parameters. In the absence of a layer, shear horizontal surface waves do not exist in a purely elastic material, but the presence of a magnetic field normal to the sagittal plane makes such waves possible, these being analogous to Bleustein–Gulyaev waves in piezoelectric materials. Such waves are discussed briefly at the end of the paper
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