A practice-led approach to facial animation research

In facial expression research, it is well established that certain emotional expressions are universally recognized. Studies into the observer perception of dynamic expressions have built upon this research by highlighting the importance of particular facial regions, timings, and temporal configurations to perception and interpretation. In many studies, the stimuli for such studies have been generated through posing by non-experts or performances by trained actors. However, skilled character animators are capable of crafting recognizable, believable emotional facial expressions as a part of their professional practice. ‘Emotional Avatars’ was conceived as an interdisciplinary research project which would draw upon the knowledge of animation practice and emotional psychology. The aim of the project was to jointly investigate the artistic generation and observer perception of emotional expression animation to determine whether the nuances of emotional facial expression could be artistically choreographed to enhance audience interpretation

Holocene variations in the Scottish marine radiocarbon reservoir effect

We assessed the evidence for variations in the marine radiocarbon reservoir effect (MRE) at coastal, archaeological Iron Age sites in north and west Scotland by comparing AMS measurements of paired marine and terrestrial materials (4 pairs per context). DeltaR values were calculated from measurements on material from 3 sites using 6 sets of samples, all of which were deposited around 2000 BP. The weighted mean of the DeltaR determinations was -79 +/- 17 C-14 yr, which indicates a consistent, reduced offset between atmospheric and surface ocean C-14 specific activity for these sites during this period, relative to the present day (DeltaR = similar to0 C-14 yr). We discuss the significance of this revised AR correction by using the example of wheelhouse chronologies at Hornish Point and their development in relation to brochs. In addition, we assess the importance of using the concepts of MRE correction and AR variations when constructing chronologies using C-14 measurements made on materials that contain marine- derived carbon

Random billiards with wall temperature and associated Markov chains

By a random billiard we mean a billiard system in which the standard specular reflection rule is replaced with a Markov transition probabilities operator P that, at each collision of the billiard particle with the boundary of the billiard domain, gives the probability distribution of the post-collision velocity for a given pre-collision velocity. A random billiard with microstructure (RBM) is a random billiard for which P is derived from a choice of geometric/mechanical structure on the boundary of the billiard domain. RBMs provide simple and explicit mechanical models of particle-surface interaction that can incorporate thermal effects and permit a detailed study of thermostatic action from the perspective of the standard theory of Markov chains on general state spaces. We focus on the operator P itself and how it relates to the mechanical/geometric features of the microstructure, such as mass ratios, curvatures, and potentials. The main results are as follows: (1) we characterize the stationary probabilities (equilibrium states) of P and show how standard equilibrium distributions studied in classical statistical mechanics, such as the Maxwell-Boltzmann distribution and the Knudsen cosine law, arise naturally as generalized invariant billiard measures; (2) we obtain some basic functional theoretic properties of P. Under very general conditions, we show that P is a self-adjoint operator of norm 1 on an appropriate Hilbert space. In a simple but illustrative example, we show that P is a compact (Hilbert-Schmidt) operator. This leads to the issue of relating the spectrum of eigenvalues of P to the features of the microstructure;(3) we explore the latter issue both analytically and numerically in a few representative examples;(4) we present a general algorithm for simulating these Markov chains based on a geometric description of the invariant volumes of classical statistical mechanics

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance

Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses. The balance between these two opposing effects is critical in the context of transplantation. Here, we report that female mice deficient in C1q (C1qa(−/−)) or C3 (C3(−/−)) reject male syngeneic grafts (HY incompatible) at an accelerated rate compared with WT mice. Intranasal HY peptide administration, which induces tolerance to syngeneic male grafts in WT mice, fails to induce tolerance in C1qa(−/−) or C3(−/−) mice. The rejection of the male grafts correlated with the presence of HY D(b)Uty-specific CD8(+) T cells. Consistent with this, peptide-treated C1qa(−/−) and C3(−/−) female mice rejecting male grafts exhibited more antigen-specific CD8(+)IFN-γ(+) and CD8(+)IL-10(+) cells compared with WT females. This suggests that accumulation of IFN-γ- and IL-10-producing T cells may play a key role in mediating the ongoing inflammatory process and graft rejection. Interestingly, within the tolerized male skin grafts of peptide-treated WT mice, IFN-γ, C1q and C3 mRNA levels were higher compared to control female grafts. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance

Transient deactivation of dorsal premotor cortex or parietal area 5 impairs feedback control of the limb in macaques

We can generate goal-directed motor corrections with surprising speed, but their neural basis is poorly understood. Here, we show that temporary cooling of dorsal premotor cortex (PMd) impaired both spatial accuracy and the speed of corrective responses, whereas cooling parietal area 5 (A5) impaired only spatial accuracy. Simulations based on optimal feedback control (OFC) models demonstrated that “deactivation” of the control policy (reduction in feedback gain) and state estimation (reduction in Kalman gain) caused impairments similar to that observed for PMd and A5 cooling, respectively. Furthermore, combined deactivation of both cortical regions led to additive impairments of individual deactivations, whereas reducing the amount of cooling to PMd led to impairments in response speed but not spatial accuracy, both also predicted by OFC models. These results provide causal support that frontoparietal circuits beyond primary somatosensory and motor cortices are involved in generating goal-directed motor corrections

Is comparability of C-14 dates an issue?: A status report on the fourth international radiocarbon intercomparison

For more than 15 years, the radiocarbon community has participated in a series of laboratory intercomparisons in response to the issue of comparability of measurements as perceived within the wider user communities (Scott et al. 1990; Rozanski et al. 1992; Guiliksen and Scott 1995; Scott et al. 1997).<br/> In this report, we provide an update on the current C-14 laboratory intercomparison and reflect on future issues linked to the laboratory intercomparison program, not least those resulting from a significant growth in the number of accelerator mass spectrometry (AMS) facilities providing routine dating of small samples (milligram size)

Rapid analysis of formic acid, acetic acid, and furfural in pretreated wheat straw hydrolysates and ethanol in a bioethanol fermentation using atmospheric pressure chemical ionisation mass spectrometry.

Atmospheric pressure chemical ionisation mass spectrometry (APCI-MS) offers advantages as a rapid analytical technique for the quantification of three biomass degradation products (acetic acid, formic acid and furfural) within pretreated wheat straw hydrolysates and the analysis of ethanol during fermentation. The data we obtained using APCI-MS correlated significantly with high-performance liquid chromatography analysis whilst offering the analyst minimal sample preparation and faster sample throughput

Some problems in the study of the chronology of the ancient nomadic cultures in Eurasia (9th - 3rd centuries BC)

This research is focused on the chronological investigations of ancient nomads belonging to the Scythian cultures which occupied the steppe and forest-steppe zones of Eurasia during the 9th-3rd centuries BC. The 14C dates for the pre-scythian and early scythian time in both Europe and Asia are presented and compared to their chronological position based on archaeological evidence. The first 14C dates have been produced for the Scythian time monuments located in the Lower Volga River basin, Urals and Transurals regions. Their chronological positions are compared with the position of the monuments of Southern Siberia and Central Asia. It was shown that the nomadic cultures belonging to the Scythian culture began to exist over the wide territory of Eurasia from the 9th-8th centuries cal BC and there are some monuments which may be synchronous to the Arzhan royal barrow (the oldest monument known). A list of new 14C dates and a map of the monuments are presented

Knowledge and Perceptions of Latent Tuberculosis Infection among Chinese Immigrants in a Canadian Urban Centre

Background. Since most tuberculosis (TB) cases in immigrants to British Columbia (BC), Canada, develop from latent TB infection (LTBI), treating immigrants for LTBI can contribute to the eradication of TB. However, adherence to LTBI treatment is a challenge that is influenced by knowledge and perceptions. This research explores Chinese immigrants\u27 knowledge and perceptions towards LTBI in Greater Vancouver. Methods. This mixed methods study included a cross-sectional patient survey at BC\u27s Provincial TB clinics and two focus group discussions (FGDs) with Chinese immigrants. Data from FGDs were coded and analyzed in Simplified Chinese. Codes, themes, and selected quotes were then translated into English. Results. The survey identified a mean basic knowledge score: 40.0% (95% CI: 38.3%, 41.7%). FGDs confirmed that Chinese immigrants\u27 knowledge of LTBI was low, and they confused it with TB disease to the extent of experiencing LTBI associated stigma. Participants also expressed difficulties navigating the health system which impeded testing and treatment of LTBI. Online videos were the preferred format for receiving health information. Conclusion. We identified striking gaps in knowledge surrounding an LTBI diagnosis. Concerns of stigma may influence acceptance and adherence of LTBI treatment in Chinese immigrants. Integrating these findings into routine health care is recommended