Australian Consumers' Concerns and Preferences for Food Policy Alternatives

Results from a 2007 Australian consumer survey conducted at a large farmers market are used to explore the hypothesis that consumers who are more concerned about certain types of food labeling information, particularly information related to food production attributes, are more likely to support policies which help develop farmers markets and support mandatory labeling policies. Product information and attributes such as Country-of-Origin, No Growth Hormones Used, Free Range and Animals Treated Humanely and Environmentally-friendly appear to be very important to consumers. It appears that respondents want increased government involvement in developing consistent food labelling standards for these attributes and support mandatory food labelling policies, however, respondents are split between whether third-parties or the Australian government should oversee regulation of the program. Some respondents appear to view a mandatory labelling policy as a method to improve competitiveness and sustainability of small food producers who want to use labelling to differentiate themselves. Respondents also tended to support the government subsidizing the development of farmers markets. Respondents viewed FM as an opportunity to gain additional information or purchase foods that have credence attributes such as pesticide-free. Thus, policies supporting FM may help alleviate market failures related to asymmetric information and lack of choice.market failure, consumers, farmers markets, labelling, Agricultural and Food Policy,

Teachers\u27 Perceptions and Experiences Consulting with School Counselors: A Qualitative Study

School counselor–teacher consultation is an efficient strategy for school counselors to indirectly serve students on their caseload. Teachers\u27 perceptions are crucial in examining this consultation process. This qualitative study examined elementary school teachers\u27 perceptions and experiences of school counselor–teacher consultation. The researchers identified three themes: (a) school counselors prioritizing relationships, (b) school counselors taking initiative, and (c) school counselors\u27 specialization. The researchers discuss implications for school counseling practice, including strategies for facilitating consultation with teachers

An Evaluation of Distinct Volumetric and Functional MRI Contributions Toward Understanding Age and Task Performance: A Study in the Basal Ganglia

Prior work by our group and others has implicated the basal ganglia as important in age-related differences in tasks involving motor response control. The present study used structural and functional MRI approaches to analyze this region of interest (ROI) toward better understanding the contributions of structural and functional MRI measures to understanding age-related and task performance-related cognitive differences. Eleven healthy elders were compared with 11 healthy younger adults while they completed the “go” portion of a complex Go/No-go task. Separate ROI\u27s in the bilateral caudate (C) and putamen/globus pallidus (PGp) were studied based upon previous findings of age-related functional MRI differences in basal ganglia for this portion of the task. Structural volumes and functional activation (in percent area under the curve during correct responses) were independently extracted for these ROI\u27s. Results showed that age correlated with ROI volume in bilateral PGp and C, while multiple task performance measures correlated with functional activation in the left PGp. The Go/No-go task measures were also significantly correlated with traditional attention and executive functioning measures. Importantly, fMRI activation and volumes from each ROI were not significantly inter-correlated. These findings suggest that structural and functional MRI make unique contributions to the study of performance changes in aging

Modelling foraging movements of diving predators : A theoretical study exploring the effect of heterogeneous landscapes on foraging efficiency

Peer reviewedPublisher PD

Peer Victimization in Students who are Deaf and Hard of Hearing: Exploring Educational Placement

Forty-five American students who are Deaf/hard of hearing (SWD/HOH) in grades 5-12 completed a survey assessing their experiences with peer victimization. Almost four-fifths reported victimizing peers over the past two months, and almost 90% reported being the victim of peer victimization during that same timeframe. The most commonly reported types of peer victimization were verbal and relational aggression. Students who attended a Deaf-only campus reported greater mean victimization than those attending magnet programs located in general education schools. The results highlight the need for evidence-based programs that address peer victimization among SWD/HOH

Five-minute Apgar score and educational outcomes: retrospective cohort study of 751 369 children

Background: The Apgar score is used worldwide for assessing the clinical condition and short-term prognosis of newborn infants. Evidence for a relationship with long-term educational outcomes is conflicting. We investigated whether Apgar score at 5 min after birth was associated with additional support needs (ASN) and educational attainment. Methods: Data on pregnancy, delivery and later educational outcomes for children attending Scottish schools between 2006 and 2011 were collated by linking individual-level data from national educational and maternity databases. The relationship between Apgar score and overall ASN, type-specific ASN and educational attainment was assessed using binary, multinomial and generalised ordinal logistic regression models, respectively. Missing covariate data were imputed. Results: Of the 751 369 children eligible, 9741 (1.3%) had a low or intermediate Apgar score and 49 962 (6.6%) had ASN. Low Apgar score was independently associated with overall ASN status (adjusted OR for Apgar ≤3, OR 1.52 95% CI 1.35 to 1.70), as well as ASN due to cognitive (OR 1.26, 95% CI 1.09 to 1.47), sensory (OR 2.49 95% CI 1.66 to 3.73) and motor (OR 3.57, 95% CI 2.86 to 4.47) impairments. There was a dose-response relationship between Apgar score and overall ASN status: of those scoring 0–3, 10.1% had ASN, compared with 9.1% of those scoring 4–7 and 6.6% of those scoring 7–10. A low Apgar score was associated with lower educational attainment, but this was not robust to adjustment for confounders. Conclusions: Apgar scores are associated with long-term as well as short-term prognoses, and with educational as well as clinical outcomes at the population level

University Students’ Coping Behaviours and Perceived Parental Depression: The Role of Hope and Implications for Counsellors

Research has shown links between perceived parental depressive symptomology and young adults’ depressive symptoms (Rounding & Jacobson, 2013). Hope has been linked to fewer depressive symptoms and to greater adaptive coping behaviours (Chang & DeSimone, 2001). The relation between perceived parental depression, hope, and undergraduate university students’ coping behaviours was examined. Participants were 223 undergraduates (51 males, 172 females) aged 17 to 24. Beyond perceived parental depression, hope predicted higher levels of religion/spirituality, active coping, and planning, and predicted lower levels of humour and behavioural disengagement. Implications for counselling clients at risk for intergenerational depression are discussed. La recherche a démontré qu’il existe des liens entre la symptomatologie de la dépression parentale perçue et les symptômes dépressifs chez les jeunes adultes (Rounding & Jacobson, 2013). On a établi un lien entre l’espoir et une diminution des symptômes de dépression et une amélioration des comportements adaptatifs (Chang & DeSimone, 2001). On a examiné la relation entre la dépression parentale perçue, l’espoir, et les comportements d’adaptation chez les étudiants universitaires de premier cycle. Les participants comptent 223 universitaires de premier cycle (51 hommes, 172 femmes) de 17 à 24 ans. Au-delà de la dépression parentale perçue, le facteur espoir a permis de prédire des niveaux plus élevés de religion/spiritualité, d’adaptation active, et de planification, tout en permettant de prédire des niveaux plus faibles sur le plan de l’humeur et du désengagement comportemental. On y discute des implications pour les clients en counseling à risque de la dépression intergénérationnelle

Effects of Landscape Composition and Configuration on Migrating Songbirds: Inference from an Individual-Based Model

The behavior of long-distance migrants during stopover is constrained by the need to quickly and safely replenish energetic reserves. Replenishing fuel stores at stopover sites requires adjusting to unfamiliar landscapes with little to no information about the distribution of resources. Despite their critical importance to the success of songbird migration, the effects of landscape composition and configuration on fuel deposition rates (FDR [g/d]), the currency of migration, has not been tested empirically. Our objectives were to understand the effects of heterogeneous landscapes on FDR of forest-dwelling songbirds during spring migration. The results of field experiments were used to parameterize a spatially explicit, individual-based model of forest songbird movement and resulting FDR. Further field experiments were used to validate the results from the individual-based model. In simulation experiments, we altered a Gulf South landscape in a factorial design to predict the effects of future patterns under different scenarios of land use change in which the abundance of high-quality hardwood habitat and the spatial aggregation of habitat varied. Simulated FDR decreased as the amount of hardwood in the landscape decreased from 41% to 22% to 12%. Further, migrants that arrived in higher-quality habitat types gained more mass. Counter to our expectations, FDR was higher with lower spatial aggregation of habitat. Differences in refueling rates may be most influenced by whether or not an individual experiences an initial searching cost after landing in poor-quality habitat. Therefore, quickly locating habitat with sufficient food resources at each stopover may be the most important factor determining a successful migration. Our findings provide empirical evidence for the argument that hardwood forest cover is a primary determinant of the quality of a stopover site in this region. This study represents the first effort to empirically quantify FDRs based on the configuration of landscapes

The MicroRNA, miR‐18a, Regulates NeuroD and Photoreceptor Differentiation in the Retina of Zebrafish

During embryonic retinal development, six types of retinal neurons are generated from multipotent progenitors in a strict spatiotemporal pattern. This pattern requires cell cycle exit (i.e. neurogenesis) and differentiation to be precisely regulated in a lineage‐specific manner. In zebrafish, the bHLH transcription factor NeuroD governs photoreceptor genesis through Notch signaling but also governs photoreceptor differentiation though distinct mechanisms that are currently unknown. Also unknown are the mechanisms that regulate NeuroD and the spatiotemporal pattern of photoreceptor development. Members of the miR‐17‐92 microRNA cluster regulate CNS neurogenesis, and a member of this cluster, miR‐18a, is predicted to target neuroD mRNA. The purpose of this study was to determine if, in the developing zebrafish retina, miR‐18a regulates NeuroD and if it plays a role in photoreceptor development. Quantitative RT‐PCR showed that, of the three miR‐18 family members (miR‐18a, b, and c), miR‐18a expression most closely parallels neuroD expression. Morpholino oligonucleotides and CRISPR/Cas9 gene editing were used for miR‐18a loss‐of‐function (LOF) and both resulted in larvae with more mature photoreceptors at 70 hpf without affecting cell proliferation. Western blot showed that miR‐18a LOF increases NeuroD protein levels and in vitro dual luciferase assay showed that miR‐18a directly interacts with the 3′ UTR of neuroD. Finally, tgif1 mutants have increased miR‐18a expression, less NeuroD protein and fewer mature photoreceptors, and the photoreceptor deficiency is rescued by miR‐18a knockdown. Together, these results show that, independent of neurogenesis, miR‐18a regulates the timing of photoreceptor differentiation and indicate that this occurs through post‐transcriptional regulation of NeuroD.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147840/1/dneu22666.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147840/2/dneu22666_am.pd

Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1

Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form of the only CYP17A1 inhibitor approved by the Food and Drug Administration, binds the catalytic heme iron, nonselectively impeding both reactions and ultimately causing undesirable corticosteroid imbalance. Some nonsteroidal inhibitors reportedly inhibit the lyase reaction more than the preceding hydroxylase reaction, which would be clinically advantageous, but the mechanism is not understood. Thus, the nonsteroidal inhibitors seviteronel and orteronel and the steroidal inhibitors abiraterone and galeterone were compared with respect to their binding modes and hydroxylase versus lyase inhibition. Binding studies and X-ray structures of CYP17A1 with nonsteroidal inhibitors reveal coordination to the heme iron like the steroidal inhibitors. (S)-seviteronel binds similarly to both observed CYP17A1 conformations. However, (S)-orteronel and (R)-orteronel bind to distinct CYP17A1 conformations that differ in a region implicated in ligand entry/exit and the presence of a peripheral ligand. To reconcile these binding modes with enzyme function, side-by-side enzymatic analysis was undertaken and revealed that neither the nonsteroidal seviteronel nor the (S)-orteronel inhibitors demonstrated significant lyase selectivity, but the less potent (R)-orteronel was 8- to 11-fold selective for lyase inhibition. While active-site iron coordination is consistent with competitive inhibition, conformational selection for binding of some inhibitors and the differential presence of a peripheral ligand molecule suggest the possibility of CYP17A1 functional modulation by features outside the active site