Making and Sharing the Commons: Reimagining ‘the West’ as Riverlands, Sydney through a Dialogue between Design and Ethnography

Scholars from the social sciences and humanities are increasingly seeking to improve the relevance and social impact of their research beyond the academy. In this context, ‘designerly’ thinking and methods are being drawn on to inform social change agendas, and a range of new relationships and collaborations are forming around this node of activity. This article critically reflects on this trajectory through a dialogue between ethnography, design and theoretical principles from anthropology and human geography

Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3

BACKGROUND: Previous studies provide evidence that adipokine leptin increases production of catabolic and proinflammatory factors in chondrocytes and serves as a link between obesity and osteoarthritis (OA). However, the magnitude of the response to leptin treatment varies greatly between chondrocytes from different donor patients. In the present study, we investigated the regulatory role of suppressor of cytokine signaling-3 (SOCS-3) in the leptin-induced responses in OA cartilage. METHODS: Cartilage and synovial fluid samples from 97 patients with OA undergoing knee replacement surgery were collected. Cartilage samples were cultured with leptin (10 μg/ml), and the levels of proinflammatory and catabolic factors in synovial fluid and in the cartilage culture media, and SOCS-3 expression in the cartilage were measured. The role of SOCS-3 in leptin signaling was further studied in H4 murine chondrocytes by downregulating SOCS-3 with siRNA. RESULTS: Leptin-induced expression of matrix metalloproteinases MMP-1, MMP-3, MMP-13, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were higher in the cartilage samples with low SOCS-3 expression. Accordingly, downregulation of SOCS-3 by siRNA in H4 chondrocytes led to enhanced leptin-induced expression of MMP-3, MMP-13, IL-6 and iNOS. Synovial fluid leptin was associated positively, and cartilage SOCS-3 negatively with synovial fluid levels of MMPs in a multivariate model in obese (body mass index (BMI) >30 kg/m2) but not in non-obese (BMI <30 kg/m2) patients. CONCLUSIONS: Our results show, for the first time, that SOCS-3 regulates leptin-induced responses in cartilage, and could thus be a future drug target in the treatment or prevention of OA, especially in obese patientsBioMed Central open acces

Funeral Service Employers\u27 Perceptions of Body Art and Hireability

The purpose of this research was to determine whether there were biases among funeral home and cemetery professionals with regards to hiring mortuary science graduates with tattoos. An anonymous survey including a photograph of either a male or female with various degrees of visible body art, ranging from none to extreme, was sent to 1484 members of the International Cemetery, Cremation and Funeral Association. The primary methodology used to determine whether biases existed regarding visible body art were a semantic differential and a hireability scale. The survey was designed to gather information related to the following three research questions: 1. What are employers’ perceptions regarding hireability of individuals based on extent of visible body art? 2. Are there differences in the employers’ perceptions regarding visible body art based on the gender of the individuals in the photographs? 3. What are the differences in perceptions regarding visible body art based on respondent age, gender, and their own extent of visible body art? Of the surveys distributed, responses totaled 151. Due to incomplete information, 74 were discarded. The number of surveys used in the analysis was 77. Results indicated no specific biases of employers\u27 perception towards potential hirees with body art. These results were based on multiple categories, including age and gender of respondent, extent of body art of respondent, and respondent position within their companies. Although the responses were neutral and showed no significant bias towards hirees with body art, mortuary science students should be aware of potential biases of the families served by the funeral homes, including age of the deceased and family members, as well as the conservative nature of the funeral profession