Impact of Nucleon-Nucleon Bremsstrahlung Rates Beyond One-Pion Exchange

Neutrino-pair production and annihilation through nucleon-nucleon bremsstrahlung is included in current supernova simulations by rates that are based on the one-pion-exchange approximation. Here we explore the consequences of bremsstrahlung rates based on a modern nuclear interactions for proto-neutron star cooling and the corresponding neutrino emission. We find that despite a reduction of the bremsstrahlung emission by a factor of 2-5 in the neutrinospheric region, models with the improved treatment exhibit only $\lesssim$5% changes of the neutrino luminosities and an increase of $\lesssim$0.7 MeV of the average energies of the radiated neutrino spectra, with the largest effects for the antineutrinos of all flavors and at late times. Overall, the proto-neutron star cooling evolution is slowed down modestly by $\lesssim$0.5-1 s.Comment: 11 pages, 7 figures, minor changes and additions, to appear in Phys. Rev.

Lock and Dam No. 26 R, Lock Cofferdam, Construction Sequencing

Construction of a new lock and dam to replace existing Locks and Dam No. 26 required construction to be accomplished in three separate stages. Each portion of the new structure would be constructed inside cellular cofferdams. The construction of each cofferdam would require model tests to determine compatibility with design flow requirements relative to constructability of coffercells, scour of riverbed material, and navigation of river vessels. Compatibility of the lock cofferdam geometry was verified using model studies along with sequence for construction of the cofferdam cells. Construction of the second stage cofferdam was successfully completed in December 1985, followed by dewatering and construction of the 1,200 foot lock structure

Protracted Protection to \u3ci\u3ePlasmodium berghei\u3c/i\u3e Malaria Is Linked to Functionally and Phenotypically Heterogeneous Liver Memory CD\u3csup\u3e8+\u3c/sup\u3e T Cells\u3csup\u3e1\u3c/sup\u3e

We previously demonstrated that protection induced by radiation-attenuated (y) Plasmodium berghei sporozoites is linked to MHC class I-restricted CD8+ T cells specific for exoerythrocytic-stage Ags, and that activated intrahepatic memory CD8+ T cells are associated with protracted protection. In this study, we further investigated intrahepatic memory CD8+ T cells to elucidate mechanisms required for their maintenance. Using phenotypic markers indicative of activation (CD44, CD45RB), migration (CD62L), and IFN-y production, we identified two subsets of intrahepatic memory CD8+ T cells: the CD44highCD45RBlowCD62LlowCD122low phenotype, representing the dominant effector memory set, and the CD44highCD45RBhighCD62Llow/highCD122high phenotype, representing the central memory set. Only the effector memory CD8+ T cells responded swiftly to sporozoite challenge by producing sustained IFN-y; the central memory T cells responded with delay, and the IFN-y reactivity was short-lived. In addition, the subsets of liver memory CD8+ T cells segregated according to the expression of CD122 (IL-15R) in that only the central memory CD8+ T cells were CD122high, whereas the effector memory CD8+ T cells were CD122low. Moreover, the effector memory CD8+ T cells declined as protection waned in mice treated with primaquine, a drug that interferes with the formation of liver-stage Ags. We propose that protracted protection induced by P. berghei radiation-attenuated sporozoites depends in part on a network of interactive liver memory CD8+ T cell subsets, each representing a different phase of activation or differentiation, and the balance of which is profoundly affected by the repository of liver-stage Ag and IL-15

What a medical school chair wants from the dean

Economic pressure has led the evolution of the role of the medical school dean from a clinician educator to a health care system executive. In addition, other dynamic requirements also have likely led to changes in their leadership characteristics. The most important relationship a dean has is with the chairs, yet in the context of the dean's changing role, little attention has been paid to this relationship. To frame this discussion, we asked medical school chairs what characteristics of a dean's leadership were most beneficial. We distributed a 26-question survey to 885 clinical and basic science chairs at 41 medical schools. These chairs were confidentially surveyed on their views of six leadership areas: evaluation, barriers to productivity, communication, accountability, crisis management, and organizational values. Of the 491 chairs who responded (response rate = 55%), 88% thought that their dean was effective at leading the organization, and 89% enjoyed working with their dean. Chairs indicated that the most important area of expertise of a dean is to define a strategic vision, and the most important value for a dean is integrity between words and deeds. Explaining the reasons behind decisions, providing good feedback, admitting errors, open discussion of complex or awkward topics, and skill in improving relations with the teaching hospital were judged as desirable attributes of a dean. Interestingly, only 23% of chairs want to be a dean in the future. Financial acumen was the least important skill a chair thought a dean should hold, which is in contrast to the skill set for which many deans are hired and evaluated. After reviewing the literature and analyzing these responses, we assert that medical school chairs want their dean to maintain more traditional leadership than that needed by a health care system executive, such as articulating a vision for the future and keeping their promises. Thus, there appears to be a mismatch between what medical school chairs perceive they need from their dean and how the success of a dean is evaluated

T0RTT: Non-Interactive Immediate Forward-Secret Single-Pass Circuit Construction

Maintaining privacy on the Internet with the presence of powerful adversaries such as nation-state attackers is a challenging topic, and the Tor project is currently the most important tool to protect against this threat. The circuit construction protocol (CCP) negotiates cryptographic keys for Tor circuits, which overlay TCP/IP by routing Tor cells over n onion routers. The current circuit construction protocol provides strong security guarantees such as forward secrecy by exchanging O(n^2) messages. For several years it has been an open question if the same strong security guarantees could be achieved with less message overhead, which is desirable because of the inherent latency in overlay networks. Several publications described CCPs which require only O(n) message exchanges, but significantly reduce the security of the resulting Tor circuit. It was even conjectured that it is impossible to achieve both message complexity O(n) and forward secrecy immediately after circuit construction (so-called immediate forward secrecy). Inspired by the latest advancements in zero round-trip time key exchange (0-RTT), we present a new CCP protocol Tor 0-RTT (T0RTT). Using modern cryptographic primitives such as puncturable encryption allow to achieve immediate forward secrecy using only O(n) messages. We implemented these new primitives to give a first indication of possible problems and how to overcome them in order to build practical CCPs with O(n) messages and immediate forward secrecy in the future

Raccoon Attack: Finding and Exploiting Most-Significant-Bit-Oracles in TLS-DH(E)

Diffie-Hellman key exchange (DHKE) is a widely adopted method for exchanging cryptographic key material in realworld protocols like TLS-DH(E). Past attacks on TLS-DH(E) focused on weak parameter choices or missing parameter validation. The confidentiality of the computed DH share, the premaster secret, was never questioned; DHKE is used as a generic method to avoid the security pitfalls of TLS-RSA. We show that due to a subtle issue in the key derivation of all TLS-DH(E) cipher suites in versions up to TLS 1.2, the premaster secret of a TLS-DH(E) session may, under certain circumstances, be leaked to an adversary. Our main result is a novel side-channel attack, named Raccoon attack, which exploits a timing vulnerability in TLS-DH(E), leaking the most significant bits of the shared Diffie-Hellman secret. The root cause for this side channel is that the TLS standard encourages non-constant-time processing of the DH secret. If the server reuses ephemeral keys, this side channel may allow an attacker to recover the premaster secret by solving an instance of the Hidden Number Problem. The Raccoon attack takes advantage of uncommon DH modulus sizes, which depend on the properties of the used hash functions. We describe a fully feasible remote attack against an otherwisesecure TLS configuration: OpenSSL with a 1032-bit DH modulus. Fortunately, such moduli are not commonly used on the Internet. Furthermore, with our large-scale scans we have identified implementation-level issues in production-grade TLS implementations that allow for executing the same attack by directly observing the contents of server responses, without resorting to timing measurements

Insulin doseresponse curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes.

To determine whether the insulin dose-response curves for suppression of endogenous glucose production (EGP) and stimulation of splanchnic glucose uptake (SGU) differ in nondiabetic humans and are abnormal in type 2 diabetes, 14 nondiabetic and 12 diabetic subjects were studied. Glucose was clamped at ϳ9.5 mmol/l and endogenous hormone secretion inhibited by somatostatin, while glucagon and growth hormone were replaced by an exogenous infusion. Insulin was progressively increased from ϳ150 to ϳ350 and ϳ700 pmol/l by means of an exogenous insulin infusion, while EGP, SGU, and leg glucose uptake (LGU) were measured using the splanchnic and leg catheterization methods, combined with a [3-3 H]glucose infusion. In nondiabetic subjects, an increase in insulin from ϳ150 to ϳ350 pmol/l resulted in maximal suppression of EGP, whereas SGU continued to increase (P < 0.001) when insulin was increased to ϳ700 pmol/l. In contrast, EGP progressively decreased (P < 0.001) and SGU progressively increased (P < 0.001) in the diabetic subjects as insulin increased from ϳ150 to ϳ700 pmol/l. Although EGP was higher (P < 0.01) in the diabetic than nondiabetic subjects only at the lowest insulin concentration, SGU was lower (P < 0.01) in the diabetic subjects at all insulin concentrations tested. On the other hand, in contrast to LGU and overall glucose disposal, the increment in SGU in response to both increments in insulin did not differ in the diabetic and nondiabetic subjects, implying a right shifted but parallel dose-response curve. These data indicate that the dose-response curves for suppression of glucose production and stimulation of glucose uptake differ in nondiabetic subjects and are abnormal in people with type 2 diabetes. Taken together, these data also suggest that agents that enhance SGU in diabetic patients (e.g. glucokinase activators) are likely to improve glucose tolerance. Diabete

Planned Marketing Adaptation and Multinationals' Choices Between Acquisitions and Greenfields

International marketing studies have extensively examined the antecedents of firms' marketing standardization/ adaptation decisions. However, it is unclear whether such decisions, once planned, codetermine the choice between buying and building foreign subsidiaries. Analyzing a sample of 150 foreign entries by Dutch firms, the authors find that the level of marketing adaptation planned for a wholly owned subsidiary is positively related to the likelihood that the subsidiary will be established through an acquisition rather than through a greenfield investment. Moreover, the authors find substantial evidence that this positive relationship is stronger for firms that (1) are establishing relatively larger subsidiaries, (2) have less experience with the industry entered, or (3) are entering less developed countries. The findings show that firms pursuing higher levels of marketing adaptation assign more value to the marketing adaptation advantages of acquisitions over greenfields, especially if the risks associated with implementing the planned adaptation level are high. In addition, firms typically strive for a fit between their international marketing strategy and their mode of foreign establishment. (authors' abstract