3,270 research outputs found
Self-duality of the D1-D5 near-horizon
We explore fermionic T-duality and self-duality in the geometry AdS3 x S3 x
T4 in type IIB supergravity. We explicitly construct the Killing spinors and
the fermionic T-duality isometries and show that the geometry is self-dual
under a combination of two bosonic AdS3 T-dualities, four fermionic T-dualities
and either two additional T-dualities along T4 or two T-dualities along S3. In
addition, we show that the presence of a B-field acts as an obstacle to
self-duality, a property attributable to S- duality and fermionic T-duality not
commuting. Finally, we argue that fermionic T-duality may be extended to CY2 =
K3, a setting where we cannot explicitly construct the Killing spinors.Comment: 24 pages, references added, changes made to reinforce the point that
S-duality and fermionic T-duality generically do not commute, version
accepted to JHE
The Conformal Manifold of Chern-Simons Matter Theories
We determine perturbatively the conformal manifold of N=2 Chern-Simons matter
theories with the aim of checking in the three dimensional case the general
prescription based on global symmetry breaking, recently introduced. We discuss
in details few remarkable cases like the N=6 ABJM theory and its less
supersymmetric generalizations with/without flavors. In all cases we find
perfect agreement with the predictions of global symmetry breaking
prescription.Comment: 1+17 pages, 1 figure, references adde
Методи оцінки ризиків в інформаційній системі аналізу екологічного стану басейну малої ріки
В інформаційній системі аналізу стану басейну малої ріки запропоновано методи оцінки ризиків на основі імовірнісних та статистичних оцінок, формалізації моделі гри з природою, прогнозування процесів підтоплення земель з використанням ланцюгів Маркова, розглянуто багато критеріальні моделі ризиків.In informational and analytical system of the small rivers’ ecological condition estimation the methods of risks modelling on the basis of likelihood and statistical estimations, formalization of models of game with nature, risk modelling and forecasting processes flooded lands using Markov chains are offered, multicriteria models of risks are considered
Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.
BACKGROUND: The recently published Clinical Practice Guidelines (CPGs) for the treatment of stages I-IV periodontitis provided evidence-based recommendations for treating periodontitis patients, defined according to the 2018 classification. Peri-implant diseases were also re-defined in the 2018 classification. It is well established that both peri-implant mucositis and peri-implantitis are highly prevalent. In addition, peri-implantitis is particularly challenging to manage and is accompanied by significant morbidity. AIM: To develop an S3 level CPG for the prevention and treatment of peri-implant diseases, focusing on the implementation of interdisciplinary approaches required to prevent the development of peri-implant diseases or their recurrence, and to treat/rehabilitate patients with dental implants following the development of peri-implant diseases. MATERIALS AND METHODS: This S3 level CPG was developed by the European Federation of Periodontology, following methodological guidance from the Association of Scientific Medical Societies in Germany and the Grading of Recommendations Assessment, Development and Evaluation process. A rigorous and transparent process included synthesis of relevant research in 13 specifically commissioned systematic reviews, evaluation of the quality and strength of evidence, formulation of specific recommendations, and a structured consensus process involving leading experts and a broad base of stakeholders. RESULTS: The S3 level CPG for the prevention and treatment of peri-implant diseases culminated in the recommendation for implementation of various different interventions before, during and after implant placement/loading. Prevention of peri-implant diseases should commence when dental implants are planned, surgically placed and prosthetically loaded. Once the implants are loaded and in function, a supportive peri-implant care programme should be structured, including periodical assessment of peri-implant tissue health. If peri-implant mucositis or peri-implantitis are detected, appropriate treatments for their management must be rendered. CONCLUSION: The present S3 level CPG informs clinical practice, health systems, policymakers and, indirectly, the public on the available and most effective modalities to maintain healthy peri-implant tissues, and to manage peri-implant diseases, according to the available evidence at the time of publication
Forecasting Player Behavioral Data and Simulating in-Game Events
Understanding player behavior is fundamental in game data science. Video
games evolve as players interact with the game, so being able to foresee player
experience would help to ensure a successful game development. In particular,
game developers need to evaluate beforehand the impact of in-game events.
Simulation optimization of these events is crucial to increase player
engagement and maximize monetization. We present an experimental analysis of
several methods to forecast game-related variables, with two main aims: to
obtain accurate predictions of in-app purchases and playtime in an operational
production environment, and to perform simulations of in-game events in order
to maximize sales and playtime. Our ultimate purpose is to take a step towards
the data-driven development of games. The results suggest that, even though the
performance of traditional approaches such as ARIMA is still better, the
outcomes of state-of-the-art techniques like deep learning are promising. Deep
learning comes up as a well-suited general model that could be used to forecast
a variety of time series with different dynamic behaviors
Fermions and Type IIB Supergravity On Squashed Sasaki-Einstein Manifolds
We discuss the dimensional reduction of fermionic modes in a recently found
class of consistent truncations of type IIB supergravity compactified on
squashed five-dimensional Sasaki-Einstein manifolds. We derive the lower
dimensional equations of motion and effective action, and comment on the
supersymmetry of the resulting theory, which is consistent with N=4 gauged
supergravity in , coupled to two vector multiplets. We compute fermion
masses by linearizing around two vacua of the theory: one that breaks
N=4 down to N=2 spontaneously, and a second one which preserves no
supersymmetries. The truncations under consideration are noteworthy in that
they retain massive modes which are charged under a U(1) subgroup of the
-symmetry, a feature that makes them interesting for applications to
condensed matter phenomena via gauge/gravity duality. In this light, as an
application of our general results we exhibit the coupling of the fermions to
the type IIB holographic superconductor, and find a consistent further
truncation of the fermion sector that retains a single spin-1/2 mode.Comment: 43 pages, 2 figures, PDFLaTeX; v2: added references, typos corrected,
minor change
5D gravity and the discrepant G measurements
It is shown that 5D Kaluza-Klein theory stabilized by an external bulk scalar
field may solve the discrepant laboratory G measurements. This is achieved by
an effective coupling between gravitation and the geomagnetic field.
Experimental considerations are also addressed.Comment: 13 pages, to be published in: Proceedings of the 18th Course of the
School on Cosmology and Gravitation: The gravitational Constant. Generalized
gravitational theories and experiments (30 April-10 May 2003, Erice). Ed. by
G. T. Gillies, V. N. Melnikov and V. de Sabbata, (Kluwer), 13pp. (in print)
(2003
Anti-α-glucose-based glycan IgM antibodies predict relapse activity in multiple sclerosis after the first neurological event
Background There is no specific serum-based biomarker for the diagnosis or prognosis of relapsing-remitting multiple sclerosis (RRMS).
Objective We investigated whether levels of IgM antibodies to Glc(alpha 1,4) Glc(alpha) (GAGA4) or to a panel of four glucose-based glycans could differentiate MS from other neurological diseases (OND) or predict risk of early relapse following first presentation (FP) of RRMS.
Methods Retrospective analysis of 440 sera samples of three cohorts: A) FP-RRMS (n = 44), OND (n = 44); B) FP-RRMS (n = 167), OND (n = 85); and C) FP (n = 100). Anti-GAGA4 IgM levels were measured by enzyme immunoassay in cohort-A and cohort-B. Cohort-C IgM antibodies to glucose-based glycan panel were measured by immunofluorescence.
Results FP-RRMS had higher levels of anti-GAGA4 IgM than OND patients (cohort-A, P = 0.01; cohort-B, P = 0.0001). Sensitivity and specificity were 27% and 97% for cohort-A; and 26% and 90% for cohort-B, respectively. In cohort-C, 58 patients experienced early relapse (= 24 months), and 11 did not experience second attack during follow-up. Kaplan-Meier curves demonstrated decrease in time to next relapse for patients positive for the antibody panel (P = 0.02, log rank).
Conclusions Serum anti-GAGA4 IgM discerns FP-RRMS patients from OND patients. Higher levels of serum anti-alpha-glucose IgM in FP patients predict imminent early relapse. Multiple Sclerosis 2009; 15: 422-430. http://msj.sagepub.co
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