1,237 research outputs found
Fibroblasts in liver cancer: functions and therapeutic translation
Accumulation of fibroblasts in the premalignant or malignant liver is a characteristic feature of liver cancer, but has not been therapeutically leveraged despite evidence for pathophysiologically relevant roles in tumour growth. Hepatocellular carcinoma is a largely non-desmoplastic tumour, in which fibroblasts accumulate predominantly in the pre-neoplastic fibrotic liver and regulate the risk for hepatocellular carcinoma development through a balance of tumour-suppressive and tumour-promoting mediators. By contrast, cholangiocarcinoma is desmoplastic, with cancer-associated fibroblasts contributing to tumour growth. Accordingly, restoring the balance from tumour-promoting to tumour-suppressive fibroblasts and mediators might represent a strategy for hepatocellular carcinoma prevention, whereas in cholangiocarcinoma, fibroblasts and their mediators could be leveraged for tumour treatment. Importantly, fibroblast mediators regulating hepatocellular carcinoma development might exert opposite effects on cholangiocarcinoma growth. This Review translates the improved understanding of tumour-specific, location-specific, and stage-specific roles of fibroblasts and their mediators in liver cancer into novel and rational therapeutic concepts.Copyright © 2023 Elsevier Ltd. All rights reserved
ECC2K-130 on NVIDIA GPUs
Abstract. Computations of small discrete logarithms are feasible even in "secure" groups, and are used as subroutines in several cryptographic protocols in the literature. For example, the Boneh-Goh-Nissim degree-2-homomorphic public-key encryption system uses generic square-root discrete-logarithm methods for decryption. This paper shows how to use a small group-specific table to accelerate these subroutines. The cost of setting up the table grows with the table size, but the acceleration also grows with the table size. This paper shows experimentally that computing a discrete logarithm in an interval of order takes only 1.93
Perturbation of Tunneling Processes by Mechanical Degrees of Freedom in Mesoscopic Junctions
We investigate the perturbation in the tunneling current caused by
non-adiabatic mechanical motion in a mesoscopic tunnel junction. A theory
introduced by Caroli et al. \cite{bi1,bi2,bi3} is used to evaluate second order
self-energy corrections for this non-equilibrium situation lacking
translational invariance. Inelastic signatures of the mechanical degrees of
freedom are found in the current-voltage characteristics. These give
rise to sharp features in the derivative spectrum, .Comment: 22 pages LaTeX + 3 uuencoded PS picture
A Simple Method to Check the Reliability of Annual Sunspot Number in the Historical Period 1610-1847
A simple method to detect inconsistencies in low annual sunspot numbers based
on the relationship between these values and the annual number of active days
is described. The analysis allowed for the detection of problems in the annual
sunspot number series clustered in a few specific periods and unambiguous,
namely: i) before Maunder minimum, ii) the year 1652 during the Maunder
minimum, iii) the year 1741 in Solar Cycle -1, and iv) the so-called "lost"
solar cycle in 1790s and subsequent onset of the Dalton Minimum.Comment: 15 pages, 3 figures, to be published in Solar Physic
Aharonov-Bohm cages in two-dimensional structures
We present an extreme localization mechanism induced by a magnetic field for
tight-binding electrons in two-dimensional structures. This spectacular
phenomenon is investigated for a large class of tilings (periodic,
quasiperiodic, or random). We are led to introduce the Aharonov-Bohm cages
defined as the set of sites eventually visited by a wavepacket that can, for
particular values of the magnetic flux, be bounded. We finally discuss the
quantum dynamics which exhibits an original pulsating behaviour.Comment: 4 pages Latex, 3 eps figures, 1 ps figur
Capture of particles of dust by convective flow
Interaction of particles of dust with vortex convective flows is under
theoretical consideration. It is assumed that the volume fraction of solid
phase is small, variations of density due to nonuniform distribution of
particles and those caused by temperature nonisothermality of medium are
comparable. Equations for the description of thermal buoyancy convection of a
dusty medium are developed in the framework of the generalized Boussinesq
approximation taking into account finite velocity of particle sedimentation.
The capture of a cloud of dust particles by a vortex convective flow is
considered, general criterion for the formation of such a cloud is obtained.
The peculiarities of a steady state in the form of a dust cloud and backward
influence of the solid phase on the carrier flow are studied in detail for a
vertical layer heated from the sidewalls. It is shown that in the case, when
this backward influence is essential, a hysteresis behavior is possible. The
stability analysis of the steady state is performed. It turns out that there is
a narrow range of governing parameters, in which such a steady state is stable.Comment: 14 pages, 10 figures, published in Physics of Fluid
Is it enough to be willing to win or do you have to be smart? The relationship between competitive worldviews, cognitive abilities, and applicant faking in personality tests
Recent research has highlighted competitive worldviews as a key predictor of faking—the intentional distortion of answers by candidates in the selection context. According to theoretical assumptions, applicants’ abilities, and especially their cognitive abilities, should influence whether faking motivation, triggered by competitive worldviews, can be turned into successful faking behavior. Therefore, we examined the influence of competitive worldviews on faking in personality tests and investigated a possible moderation of this relationship by cognitive abilities in three independent high school and university student samples (N1 = 133, N2 = 137, N3 = 268). Our data showed neither an influence of the two variables nor of their interaction on faking behavior. We discuss possible reasons for these findings and give suggestions for further research
Approximation of excitonic absorption in disordered systems using a compositional component weighted CPA
Employing a recently developed technique of component weighted two particle
Green's functions in the CPA of a binary substitutional alloy we
extend the existing theory of excitons in such media using a contact potential
model for the interaction between electrons and holes to an approximation which
interpolates correctly between the limits of weak and strong disorder. With our
approach we are also able to treat the case where the contact interaction
between carriers varies between sites of different types, thus introducing
further disorder into the system. Based on this approach we study numerically
how the formation of exciton bound states changes as the strengths of the
contact potentials associated with either of the two site types are varied
through a large range of parameter values.Comment: 27 pages RevTeX (preprint format), 13 Postscript figure file
The Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction across a tunneling junction out of equilibrium
The Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction between two magnetic
- spin impurities across a tunneling junction is studied when the system
is driven out of equilibrium through biasing the junction. The nonequilibrium
situation is handled with the Keldysh time-loop perturbation formalism in
conjunction with appropriate coupling methods for tunneling systems due to
Caroli and Feuchtwang. We find that the presence of a nonequilibrium bias
across the junction leads to an interference of several fundamental
oscillations, such that in this tunneling geometry, it is possible to tune the
interaction between ferromagnetic and antiferromagnetic coupling at a fixed
impurity configuration, simply by changing the bias across the junction.
Furthermore, it is shown that the range of the RKKY interaction is altered out
of equilibrium, such that in particular the interaction energy between two
slabs of spins scales extensively with the thickness of the slabs in the
presence of an applied bias.Comment: 38 pages revtex preprint; 5 postscript figures; submitted to Phys.
Rev.
- …