9 research outputs found
The Utility of Human Milk Oligosaccharides against Group B Streptococcus Infections of Reproductive Tissues and Cognate Adverse Pregnancy Outcomes
- Author
- Publication venue
- American Chemical Society
- Publication date
- 01/08/2023
- Field of study
A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/03/2020
- Field of study
Group B Streptococcus is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the utility of antibiotics.Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to which GBS is intrinsically resistant. Reductions in the MIC of TMP reached as high as 512-fold across a diverse panel of isolates. To better understand HMOs’ mechanism of action, we characterized the metabolic response of GBS to HMO treatment using ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UPLC-HRMS/MS) analysis. These data showed that when challenged by HMOs, GBS undergoes significant perturbations in metabolic pathways related to the biosynthesis and incorporation of macromolecules involved in membrane construction. This study represents reports the metabolic characterization of a cell that is perturbed by HMOs
Macrophytes and metaphyton as habitats for insects in temporary and permanent tropical aquatic ecosystems
- Author
- Azim ME
- Chambers PA
- CONABIO
- Courthey GW
- Cranston PS
- Dos Santos AM
- Elías-Gutiérrez M
- Ferrington LCJ
- García-Bedoya D.
- Goldsborough G
- Goldsborough LG
- Ibarra C
- Lot A
- Mccafferty WP
- Merdiz G
- Merrit RW
- Merritt R
- Novelo-Gutiérrez R.
- Novelo-Gutiérrez R.
- Olmstend I
- Polhemus JT
- Reynolds CS
- Schuyler AE
- SEMARNAP
- Tennesen kJ
- Thomas SM
- Thomaz SM
- Wallace JL
- Waltz RD
- White DS
- Zambrano L
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Invented lands/discovered pasts: The westward expansion of myth and history
- Author
- A B McCullough
- A Wylie
- A Wylie
- A Wylie
- A Wylie
- A Wylie
- A Wylie
- B G Trigger
- B G Trigger
- C E J Chambers
- C G Hempel
- C Kluckhohn
- C Kluckhohn
- C P Russell
- C R Fish
- C Wissler
- D H Thomas
- D H Thomas
- D H Thomas
- D J Haraway
- D L Clarke
- D L Hardesty
- D L Hardesty
- E West
- F Suppes
- G J Farris
- G J Farris
- H Glassie
- I Hodder
- J C Harrington
- J D Prown
- J E Fitting
- J Friedman
- J G Costello
- J G Costello
- J S Murray
- J S Murray
- J S Murray
- J S Murray
- J Tompkins
- J V Sciscenti
- J V Sciscenti
- J W Bennett
- J W Olsen
- K Deagan
- K Deagan
- K G Lightfoot
- K Karklins
- K V Flannery
- L R Binford
- L R Binford
- L R Binford
- L White Jr.
- M A Wylie
- M Bungé
- M P Leone
- M Praetzellis
- M Purser
- O Klimko
- P N Limerick
- P N Limerick
- R Ascher
- R B Dixon
- R B Dixon
- R B Dixon
- R B Dixon
- R B Dixon
- R B Dixon
- R G Collingwood
- R G Collingwood
- R Handsman
- R Harré
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- R L Schuyler
- R S Greenwood
- R S Greenwood
- R White
- S L DeVore
- S South
- T R Hester
- T S Kuhn
- W Cronon
- W R Swagerty
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Impacts of Saltwater Incursion on Plant Communities, Anaerobic Microbial Metabolism, and Resulting Relationships in a Restored Freshwater Wetland
- Author
- A Sutton-Grier
- AA Snow
- AE Santoro
- AE Schuyler
- AH Baldwin
- AJ Burgin
- Amy J. Burgin
- Ashley M. Helton
- B Kayranli
- B McCune
- B Steudel
- B Sundby
- B Sundby
- BC Crump
- C Craft
- CB Craft
- CJF Braak ter
- CM Crain
- CS Hopkinson
- D Emerson
- D Scharfy
- DA Adams
- DR Lovley
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- EE Roden
- EH Stanley
- FY Wang
- GA Meehl
- GB Noe
- GJ Taylor
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- H Fossing
- HJ Poffenbarger
- I Brettar
- IA Mendelssohn
- J Braun-Blanquet
- JE Kostka
- JE Perry III
- JG Engels
- JK Keller
- JL Meyer
- JL Morse
- JT Westrich
- JX Yang
- KL Lowe
- KN Hopfensperger
- Kristine N. Hopfensperger
- LG Chambers
- M Ardón
- M Ardón
- MD Bertness
- ME Hines
- ML Jackson
- MS Koch
- MW Palmer
- NB Weston
- NB Weston
- PJ Mulholland
- PJ Sharpe
- PJ Sharpe
- RD DeLaune
- RL Simpson
- RMM Crawford
- RW Howarth
- RW Howarth
- SC Neubauer
- SC Neubauer
- SC Neubauer
- SC Neubauer
- SC Pennings
- SK Dodla
- Valerie A. Schoepfer
- W Armstrong
- WE Odum
- WK Michener
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Late Cretaceous Aquatic Plant World in Patagonia, Argentina
- Author
- A Archangelsky
- A Ardolino
- A Cattaneo
- A Cruickshank
- A Iglesias
- AE Schuyler
- AM Albino
- AR Schultz
- B Mohr
- B Van Geel
- C Blanc-Louvel
- C Coiffard
- C Martin-Closas
- C Náñez
- CC Hoffman
- CCL Fiori
- CJ Heusser
- Dana L. Royer
- DH Mai
- DJ Batten
- DJ Batten
- DJ Batten
- DJ Batten
- DJP Swift
- DM Johnson
- DR Lawver
- E Alonso Paz
- E Estrada-Ruiz
- E Koch
- EE McIver
- EJ Hermsen
- Elizabeth Hermsen
- G Cambon
- GA Janauer
- GE Crow
- GW Rothwell
- GW Rougier
- H Schneider
- H Wang
- J Franzese
- J Gallego
- J Kvaček
- J Sterli
- JB Grace
- JC Horne
- JE Sanders
- JF Bonaparte
- JP O'Gorman
- JP O'Gorman
- JS Metzgar
- JW Thieret
- JW Thieret
- KM Flynn
- LB Golovneva
- LD Stamp
- M Dettman
- M Finlayson
- MA Gandolfo
- MA Gandolfo
- MA Gandolfo
- MA Gandolfo
- María A. Gandolfo
- María C. Zamaloa
- MC Zamaloa
- MC Zamaloa
- ME Collinson
- ME Collinson
- MV Guler
- N Malumián
- N. Rubén Cúneo
- NR Cúneo
- P Lacoul
- PA Chambers
- PA Zippi
- R Boyd
- R Lupia
- R Pascual
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- Y Li
- Z Gasparini
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- Z Kvaček
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Moving Beyond Mindfulness: Defining Equanimity as an Outcome Measure in Meditation and Contemplative Research
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- Manning Wendy
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- Martinelli Phylis Cancilla
- Masaoka
- Masaoka Mark
- Mason Sarah R
- Masumoto
- Mathews Anne J
- Matute-Bianchi Maria Eugenia
- McAfee Ward M
- McCallus Joseph Patrick
- McCullough David Willis
- McCunn Ruthanne Lum
- McDonald
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- McGhee Patricia A
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- McKinzie Edith Kawelohea
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- Michael
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- Momoko
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- Myers Judy
- Myers K.M.
- Nachman Elizabeth
- Nagoshi C.T. F.M.
- Nagoshi Craig T
- Nakanishi D.T.
- Nakayama Takeshi
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- Nation
- National
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- National Science Foundation.
- Netzer Dick
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- Newcomb Michael D
- Newcomb Michael D. G.J.
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- Ngor
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- Nomura Gail M
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- Ogawa Dennis M
- Ogawa Yuri
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- Okazaki
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- Omatsu Glenn
- Omi
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- Orfield
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- Orfield Gary
- Osako Masako M
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- Park
- Park Christine
- Parker
- Parrish R.G.
- Paskowski M.
- Payton Carolyn R
- Payton Robert L
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- Perea Jacob Evanjelisto
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- Peters David
- Peters Gary L
- Peters Gary L
- Peterson Sally
- Pham T.N.
- Philp Kenneth R
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- Pouesi Daniel I
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- Powell Robert G
- Powers Stephen
- Powers Stephen
- Pozo S.
- Praetzellis Adrian
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- Puette Bill
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- Qmatsu Glenn
- Quigg Agnes
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- Report
- Rescorla Leslie
- Reyes Vince
- Reyes Vince
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- Roos Patricia A
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- Ryan Angela Shen
- Rynearson Ann M
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- St. Andrews B.A.
- Stack John F
- Stanley J.C.
- State of the County Los Angeles 1987. Los Angeles
- Stavig G.R.
- Stein M.L.
- Steinberg Laurence
- Steiner Dale R
- Steingasser Jean
- Stephens Michael
- Stern Bernard W
- Stewart Frank
- Stolarik M.
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- Stoneburner Bryan C
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- Strom Robert
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- Sue David
- Suh Hyuk-Kyo
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- Suzuki Peter T
- Swartout Robert R
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- Takaki Ronald
- Tan Thomas
- Tanaka Ronald
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- Tran Thanh Van
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- Trotter Rhonda
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- Tsuchida Nobuya
- Tsukamoto Mary
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- Vellela
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- Viray Manuel A
- Viviano Frank
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- Wada Yori
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- Waldinger Roger D
- Walls Thomas K
- Wang Wayne
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- Washington Michael
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- Weeks Charles J. Jr.
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- Wendt Albert
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- Westermeyer Joseph
- Whang Minsun Sung
- White C.
- White Virginia
- Whitehead John S
- Wiley Richard
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- Williams R.A. Jr.
- Wilson William H
- Wolf Charlotte
- Wolf Susan
- Wolfram Walt
- Woll Allen L
- Won-Doornink Myong Jin
- Wong H.K.
- Wong Jerry
- Wong Marshall J
- Wong Shawn
- Wong Shelley Diane
- Wong-Chu Jim
- WongHo Leung
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- Wright Doris J
- Wright Ian
- Yamane Tokio
- Yao E.L.
- Yao E.L.
- Yao Esther Lee
- Yee Barbara W
- Yeung Alexander
- Yoneda Karl Goso
- Yoo Suisun
- Young Rosalie F
- Yu Diane C
- Yu Eui-Young
- Yu Eui-Young
- Yuan D.Y.
- Yuen Shirley Mark
- Zanger Virginia Vogel
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