The chemical potential of the electron gas on a one dimensional lattice

The chemical potential of the electron gas on a one-dimensional lattice is determined within the discrete Hubbard model. The result will have applications in studies of transport properties of quasi one-dimensional organic conductors such as the Bechgaard salts.Comment: 4 pages,plain TeX,presented at the 9 National Congress of Yugoslav Physicists,held in May 1995.,and published in the proceedings.The author can be contacted at: [email protected]

Causes of limited survival of microencapsulated pancreatic islet grafts

Successful transplantation of pancreatic tissue has been demonstrated to be an efficacious method of restoring glycemic control in type 1 diabetic patients. To establish graft acceptance patients require lifelong immunosuppression, which in turn is associated with severe deleterious side effects. Microencapsulation is a technique that enables the transplantation of pancreatic islets in the absence of immunosuppression by protecting the islet tissue through a mechanical barrier. This protection may even allow for the transplantation of animal tissue, which opens the perspective of using animal donors as a means to solve the problem of organ shortage. Microencapsulation is not yet applied in clinical practice, mainly because encapsulated islet graft survival is limited. In the present review we discuss the principal causes of microencapsulated islet graft failure, which are related to a lack of biocompatibility, limited immunoprotective properties, and hypoxia. Next to the causes of encapsulated islet graft failure we discuss possible improvements in the encapsulation technique and additional methods that could prolong encapsulated islet graft survival. Strategies that may well support encapsulated islet grafts include co-encapsulation of islets with Sertoli cells, the genetic modification of islet cells, the creation of an artificial implantation site, and the use of alternative donor sources. We conclude that encapsulation in combination with one or more of these additional strategies may well lead to a simple and safe transplantation therapy as a cure for diabetes

Positioning of nuclei in the secondary mycelium of Schizophyllum commune in relation to differential gene expression

In this paper we propose a novel type of gene regulation in the MATA not equal MATB not equal heterokaryon of Schizophyllum commune by means of differential positioning of the nuclei. It was found that binucleate hyphae with juxtaposed nuclei secrete SC4 hydrophobin (abundant during fruit-body formation), while SC3 (abundant during aerial hyphae formation in both mono- and dikaryons) appeared to be absent. Certain growth conditions disrupted the binucleate state in that the compatible nuclei became separated at a considerable distance. Under these conditions SC4 was not secreted while SC3 was secreted to a high degree. Disruption of the binucleate state was earlier observed in developing aerial hyphae which secrete SC3. Apparently when the nuclei are in close proximity the dikaryon-expressed genes are switched on by interaction of the products of the MATA and MATB mating-type genes, while SC3 is suppressed by interacting products of the MATB genes, as occurs in the common MATA heterokaryon (MATA = MATB not equal). Growth conditions that lead to disruption of the binucleate state apparently result in abolishment of interaction between the MATB mating-type genes, Under these conditions, dikaryon-specific mRNAs do not accumulate in the MATA not equal MATB not equal heterokaryon, while SC3 mRNA becomes highly abundant. (C) 1998 Academic Press