765 research outputs found
Implementation of interconnect simulation tools in spice
Accurate computer simulation of high speed digital computer circuits and communication circuits requires a multimode approach to simulate both the devices and the interconnects between devices. Classical circuit analysis algorithms (lumped parameter) are needed for circuit devices and the network formed by the interconnected devices. The interconnects, however, have to be modeled as transmission lines which incorporate electromagnetic field analysis. An approach to writing a multimode simulator is to take an existing software package which performs either lumped parameter analysis or field analysis and add the missing type of analysis routines to the package. In this work a traditionally lumped parameter simulator, SPICE, is modified so that it will perform lossy transmission line analysis using a different model approach. Modifying SPICE3E2 or any other large software package is not a trivial task. An understanding of the programming conventions used, simulation software, and simulation algorithms is required. This thesis was written to clarify the procedure for installing a device into SPICE3E2. The installation of three devices is documented and the installations of the first two provide a foundation for installation of the lossy line which is the third device. The details of discussions are specific to SPICE, but the concepts will be helpful when performing installations into other circuit analysis packages
High-Performance Computing for the Electromagnetic Modeling and Simulation of Interconnects
The electromagnetic modeling of packages and interconnects plays a very important role in the design of high-speed digital circuits, and is most efficiently performed by using computer-aided design algorithms. In recent years, packaging has become a critical area in the design of high-speed communication systems and fast computers, and the importance of the software support for their development has increased accordingly. Throughout this project, our efforts have focused on the development of modeling and simulation techniques and algorithms that permit the fast computation of the electrical parameters of interconnects and the efficient simulation of their electrical performance
The effect on actin ATPase of phalloidin and tetramethylrhodamine phalloidin
AbstractActin polymerization has been studied in the absence of excess nucleotide. Using G-actin ATP monomers, it was shown that mechanical shearing stimulates ATP hydrolysis. The procedures used enabled the detection of differential effects of phalloidin and tetramethylrhodamine-phalloidin, on the Pi-release step of the actin ATPase. It is concluded that tetramethylrhodamine, in contrast to phalloidin, accelerates Pi-release from actin filaments
Using macroinvertebrate community composition to distinguish between natural and anthropogenic sedimentation
Excess fine sediment from human activity is a major pollutant to streams across the U.S.; however, distinguishing human-induced sedimentation from natural fine sediment is complex. The U.S. Environmental Protection Agency recently implemented a protocol for the quantitative field assessment of human-induced sedimentation using measurements of stream geomorphology. Macroinvertebrate community composition, streambed sediment stability, and sediment composition were studied at 49 sites in the James River watershed in central Virginia. Sediment composition was found to be a stronger driver of community composition than sediment stability. Although I was not able to show that macroinvertebrate metrics were related to sediment stability independently of actual fine sediment composition, some metrics, including percent Ephemeridae, a family of burrowing mayflies (order = Ephemeroptera) show promise as valuable tools for regional biologists and resource managers to discriminate among streams considered impaired for sediment pollution
Multi-wavelength observations of 2HWC J1928+177: dark accelerator or new TeV gamma-ray binary?
2HWC J1928+177 is a Galactic TeV gamma-ray source detected by the High
Altitude Water Cherenkov (HAWC) Observatory up to ~ 56 TeV. The HAWC source,
later confirmed by H.E.S.S., still remains unidentified as a dark accelerator
since there is no apparent supernova remnant or pulsar wind nebula detected in
the lower energy bands. The radio pulsar PSR J1928+1746, coinciding with the
HAWC source position, has no X-ray counterpart. Our SED modeling shows that
inverse Compton scattering in the putative pulsar wind nebula can account for
the TeV emission only if the unseen nebula is extended beyond r ~ 4 [arcmin].
Alternatively, TeV gamma rays may be produced by hadronic interactions between
relativistic protons from an undetected supernova remnant associated with the
radio pulsar and a nearby molecular cloud G52.9+0.1. NuSTAR and Chandra
observations detected a variable X-ray point source within the HAWC error
circle, potentially associated with a bright IR source. The X-ray spectra can
be fitted with an absorbed power-law model with cm and and exhibit
long-term X-ray flux variability over the last decade. If the X-ray source,
possibly associated with the IR source (likely an O star), is the counterpart
of the HAWC source, it may be a new TeV gamma-ray binary powered by collisions
between the pulsar wind and stellar wind. Follow-up X-ray observations are
warranted to search for diffuse X-ray emission and determine the nature of the
HAWC source.Comment: accepted to ApJ, 8 pages, 7 figure
Nurses\u27 Alumnae Association Bulletin - Volume 5 Number 8
Calling All Nurses
Financial Report
Calendar of Events
Lest You Forget!
Attention
Review of the Alumnae Association Meetings
President\u27s Report
Barton Memorial Division
Oxygen Therapy
Welcome, White Haven Alumnae
Clinical Use of Penicillin in Infections of the Ears, Nose and Throat
Address - Graduation of Nurses, 1945
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The Blood that Kills
The Story of Malaria
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Capping Exercises
The Economic Security Program of the Pennsylvania State Nurses\u27 Association
The Clara Melville Scholarship Fund
Card of Thanks
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Jefferson Medical College Hospital School of Nursing Faculty
Jefferson Hospital Gray Lady Unite, A.R.R.
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The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
Prion strains are characterized by differences in the outcome of disease, most notably incubation period and neuropathological features. While it is established that the disease specific isoform of the prion protein, PrPSc, is an essential component of the infectious agent, the strain-specific relationship between PrPSc properties and the biological features of the resulting disease is not clear. To investigate this relationship, we examined the amplification efficiency and conformational stability of PrPSc from eight hamster-adapted prion strains and compared it to the resulting incubation period of disease and processing of PrPSc in neurons and glia. We found that short incubation period strains were characterized by more efficient PrPSc amplification and higher PrPSc conformational stabilities compared to long incubation period strains. In the CNS, the short incubation period strains were characterized by the accumulation of N-terminally truncated PrPSc in the soma of neurons, astrocytes and microglia in contrast to long incubation period strains where PrPSc did not accumulate to detectable levels in the soma of neurons but was detected in glia similar to short incubation period strains. These results are inconsistent with the hypothesis that a decrease in conformational stability results in a corresponding increase in replication efficiency and suggest that glia mediated neurodegeneration results in longer survival times compared to direct replication of PrPSc in neurons
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