Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients

Introduction: Facial lipoatrophy is a crucial problem of HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Poly-L-lactic acid (PLA), provided as New-Fill(R)/Sculptra(TM), is known as one possible treatment option. In 2004 PLA was approved by the FDA as Sculptra(TM) for the treatment of lipoatrophy of the face in HIV-infected patients. While the first trials demonstrated relevant efficacy, this was to some extent linked to unwanted effects. As the depth of injection was considered relevant in this context, the application modalities of the preparation were changed. The preparation was to be injected more deeply into subcutaneous tissue, after increased dilution. Material and Methods: To test this approach we performed a pilot study following the new recommendations in 14 patients. Results: While the efficacy turned out to be about the same, tolerability was markedly improved. The increase in facial dermal thickness was particularly obvious in those patients who had suffered from lipoatrophy for a comparatively small period of time. Conclusion: With the new recommendations to dilute PLA powder and to inject it into the deeper subcutaneous tissue nodule formation is a minor problem. However, good treatment results can only be achieved if lipoatrophy is not too intense; treatment intervals should be about 2 - 3 weeks. Copyright (C) 2005 S. Karger AG, Basel

Quantum manipulation via atomic-scale magnetoelectric effects

Magnetoelectric effects at the atomic scale are demonstrated to afford unique functionality. This is shown explicitly for a quantum corral defined by a wall of magnetic atoms deposited on a metal surface where spin-orbit coupling is observable. We show these magnetoelectric effects allow one to control the properties of systems placed inside the corral as well as their electronic signatures; they provide alternative tools for probing electronic properties at the atomic scale

Plasmonic nanoparticle monomers and dimers: From nano-antennas to chiral metamaterials

We review the basic physics behind light interaction with plasmonic nanoparticles. The theoretical foundations of light scattering on one metallic particle (a plasmonic monomer) and two interacting particles (a plasmonic dimer) are systematically investigated. Expressions for effective particle susceptibility (polarizability) are derived, and applications of these results to plasmonic nanoantennas are outlined. In the long-wavelength limit, the effective macroscopic parameters of an array of plasmonic dimers are calculated. These parameters are attributable to an effective medium corresponding to a dilute arrangement of nanoparticles, i.e., a metamaterial where plasmonic monomers or dimers have the function of "meta-atoms". It is shown that planar dimers consisting of rod-like particles generally possess elliptical dichroism and function as atoms for planar chiral metamaterials. The fabricational simplicity of the proposed rod-dimer geometry can be used in the design of more cost-effective chiral metamaterials in the optical domain.Comment: submitted to Appl. Phys.

Detection and Cloaking of Molecular Objects in Coherent Nanostructures Using Inelastic Electron Tunneling Spectroscopy

We address quantum invisibility in the context of electronics in nanoscale quantum structures. We make use of the freedom of design that quantum corrals provide and show that quantum mechanical objects can be hidden inside the corral, with respect to inelastic electron scattering spectroscopy in combination with scanning tunneling microscopy, and we propose a design strategy. A simple illustration of the invisibility is given in terms of an elliptic quantum corral containing a molecule, with a local vibrational mode, at one of the foci. Our work has implications to quantum information technology and presents new tools for nonlocal quantum detection and distinguishing between different molecules.Comment: 5 pages, 4 figures, accepted in the Nano Letter

Successful user operation of a superconducting radio-frequency photoelectron gun with Mg cathodes

At the electron linac for beams with high brilliance and low emittance (ELBE) center for high-power radiation sources, the second version of a superconducting radio-frequency (SRF) photoinjector has been put into operation and has been routinely applied for user operation at the ELBE electron accelerator. SRF guns are suitable for generating a continuous wave electron beam with high average currents and high beam brightness. The SRF gun at ELBE has the goal to generate short electron pulses with bunch charges of 200–300 pC at typical repetition rates of 100 kHz for the production of superradiant, coherent terahertz radiation. The SRF gun includes a 3.5-cell, 1.3-GHz niobium cavity and a superconducting solenoid. A support system with liquid nitrogen (LN2) cooling allows the operation of normal-conducting, high quantum efficiency photocathodes. We present the design and performance of the SRF gun as well as beam measurement results of the operation with Mg photocathodes at an acceleration gradient of 8  MV/m (4 MeV kinetic energy). In the last section, we discuss the SRF gun application for production of coherent terahertz radiation at the ELBE facility

Ultra-broadband Light Absorption by a Sawtooth Anisotropic Metamaterial Slab

We present an ultra broadband thin-film infrared absorber made of saw-toothed anisotropic metamaterial. Absorbtivity of higher than 95% at normal incidence is supported in a wide range of frequencies, where the full absorption width at half maximum is about 86%. Such property is retained well at a very wide range of incident angles too. Light of shorter wavelengths are harvested at upper parts of the sawteeth of smaller widths, while light of longer wavelengths are trapped at lower parts of larger tooth widths. This phenomenon is explained by the slowlight modes in anisotropic metamaterial waveguide. Our study can be applied in the field of designing photovoltaic devices and thermal emitters.Comment: 12 pages, 4 picture