Representation, Narrative, and “Truth”: Literary and Historical Epistemology in 19th-Century France

My thesis examines the fluid boundaries between French historical and literary writing in the 19th century, and the shifts in “historical consciousness” that occurred in both fields as the century progressed. I examine three exemplary French writers—Jules Michelet, a historian, and Honore de Balzac and Emile Zola, both novelists—considering each primarily as a historical thinker, regardless of whether they considered themselves to be one. I argue that as the 19th century progressed, the broad shift in French institutions towards positivist epistemological and explanatory frameworks was reflected in literature, as well as in history. Both disciplines, one increasingly academic and one primarily cultural, were affected in strikingly similar ways by the influence of positivism and scientism, providing a distinct aesthetic and rhetorical lens through which the impact of post-1848 positivism can be understood. As positivism infiltrated the practice of history, pushing the discipline farther into the realm of science, so too did it affect the historical thinking of prominent novelists. Additionally, I argue that the shift in historical consciousness reflects broader social fragmentation as France vacillated between various forms of government and their attendant social ideologies across the century. As political regimes and ideologies came and went, novelists, like historians, turned to rationalist frameworks, rather than idealistic or metaphysical ones, to explain their rapidly evolving political, social, and cultural moments. In addition to analyzing the impact these shifts had on historical consciousness in France, my thesis attempts to understand how historical thinking changes in response to shifts in institutional authority and ideology

Elimination of pain improves specificity of clinical diagnostic criteria for adult chronic rhinosinusitis

Objective Determine whether the elimination of pain improves accuracy of clinical diagnostic criteria for adult chronic rhinosinusitis. Study Design Retrospective cohort study. Methods History, symptoms, nasal endoscopy, and computed tomography (CT) results were analyzed for 1,186 adults referred to an academic otolaryngology clinic with presumptive diagnosis of chronic rhinosinusitis. Clinical diagnosis was rendered using the 1997 Rhinosinusitis Taskforce (RSTF) Guidelines and a modified version eliminating facial pain, ear pain, dental pain, and headache. Results Four hundred seventy-nine subjects (40%) met inclusion criteria. Among subjects positive by RSTF guidelines, 45% lacked objective evidence of sinonasal inflammation by CT, 48% by endoscopy, and 34% by either modality. Applying modified RSTF diagnostic criteria, 39% lacked sinonasal inflammation by CT, 38% by endoscopy, and 24% by either modality. Using either abnormal CT or endoscopy as the reference standard, modified diagnostic criteria yielded a statistically significant increase in specificity from 37.1% to 65.1%, with a nonsignificant decrease in sensitivity from 79.2% to 70.3%. Analysis of comorbidities revealed temporomandibular joint disorder, chronic cervical pain, depression/anxiety, and psychiatric medication use to be negatively associated with objective inflammation on CT or endoscopy. Conclusion Clinical diagnostic criteria overestimate the prevalence of chronic rhinosinusitis. Removing facial pain, ear pain, dental pain, and headache increased specificity without a concordant loss in sensitivity. Given the high prevalence of sinusitis, improved clinical diagnostic criteria may assist primary care providers in more accurately predicting the presence of inflammation, thereby reducing inappropriate antibiotic use or delayed referral for evaluation of primary headache syndromes. Level of Evidence4. Laryngoscope, 127:1011-1016, 201

Analysis of the effects of baffles on combustion instability

An analytical model has been developed for predicting the effects of baffles on combustion instability. This model has been developed by coupling an acoustic analysis of the wave motion within baffled chambers with a model for the oscillatory combustion response of a propellant droplet developed by Heidmann. A computer program was developed for numerical solution of the resultant coupled equations. Diagnostic calculations were made to determine the reasons for the improper prediction. These calculations showed that the chosen method of representing the combustion response was a very poor approximation. At the end of the program, attempts were made to minimize this effect but the model still improperly predicts the stability trends. Therefore, it is recommended that additional analysis be done with an improved approximation

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Considerable evidence suggests that the formation of long-term memories requires a critical period of new protein synthesis. Recently, the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction. Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area

Primary Biliary Cirrhosis with Systemic Sclerosis

Two patients with combinedbilian/ cirrhosis and scleroderma are described. Both patients also presented features of the CRST syndrome, namely Raynaud\u27s phenomenon, and telangiectasiae. Nine previously reported cases are reviewed and the clinical data suggest that a common underlying immunologic basis may account for both clinical conditions

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-PAINT

In the brain, the strength of each individual synapse is defined by the complement of proteins present or the "local proteome." Activity-dependent changes in synaptic strength are the result of changes in this local proteome and posttranslational protein modifications. Although most synaptic proteins have been identified, we still know little about protein copy numbers in individual synapses and variations between synapses. We use DNA-point accumulation for imaging in nanoscale topography as a single-molecule super-resolution imaging technique to visualize and quantify protein copy numbers in single synapses. The imaging technique provides near-molecular spatial resolution, is unaffected by photobleaching, enables imaging of large field of views, and provides quantitative molecular information. We demonstrate these benefits by accessing copy numbers of surface AMPA-type receptors at single synapses of rat hippocampal neurons along dendritic segments