868 research outputs found
Video signal processing system uses gated current mode switches to perform high speed multiplication and digital-to-analog conversion
Video signal processor uses special-purpose integrated circuits with nonsaturating current mode switching to accept texture and color information from a digital computer in a visual spaceflight simulator and to combine these, for display on color CRT with analog information concerning fading
Local RBF approximation for scattered data fitting with bivariate splines
In this paper we continue our earlier research [4] aimed at developing effcient methods of local approximation suitable for the first stage of a spline based two-stage scattered data fitting algorithm. As an improvement to the pure polynomial local approximation method used in [5], a hybrid polynomial/radial basis scheme was considered in [4], where the local knot locations for the RBF terms were selected using a greedy knot insertion algorithm. In this paper standard radial local approximations based on interpolation or least squares are considered and a faster procedure is used for knot selection, signicantly reducing the computational cost of the method. Error analysis of the method and numerical results illustrating its performance are given
Proton Wires in an Electric Field: the Impact of Grotthuss Mechanism on Charge Translocation
We present the results of the modeling of proton translocation in finite
H-bonded chains in the framework of two-stage proton transport model. We
explore the influence of reorientation motion of protons, as well as the effect
of electric field and proton correlations on system dynamics. An increase of
the reorientation energy results in the transition of proton charge from the
surrounding to the inner water molecules in the chain. Proton migration along
the chain in an external electric field has a step-like character, proceeding
with the occurrence of electric field threshold-type effects and drastic
redistribution of proton charge. Electric field applied to correlated chains
induces first a formation of ordered dipole structures for lower field
strength, and than, with a further field strength increase, a stabilization of
states with Bjerrum D-defects. We analyze the main factors responsible for the
formation/annihilation of Bjerrum defects showing the strong influence of the
complex interplay between reorientation energy, electric field and temperature
in the dynamics of proton wire.Comment: 28 pages, 9 figure
Comparison of Single-Element and Multi-Element Oxygen/RP-1 Oxidizer-Rich Staged-Combustion Injector Hot-Fire Test Results
As part of the Combustion Stability Tool Development project funded by the Air Force Space and Missile Systems Center, the NASA Marshall Space Flight Center designed, fabricated, assembled and hot-fire tested an oxygen/hydrocarbon propellant multi-element integrated test article that included an oxidizer-rich oxygen/hydrocarbon propellant preburner and a staged-combustion main injector. Also as part of this project, the Air Force Research Laboratory fabricated single-element main injectors of the same designs as used in the NASA multi-element injectors, and tested them in a staged-combustion integrated test article that used an oxidizer-rich oxygen/hydrogen propellant preburner. Final results of the multi-element and single-element staged-combustion main injector test programs are described in companion papers at this JANNAF meeting. The design, development, and preliminary test results of these main injectors have also been described in previous JANNAF papers. The main injector element designs were all based on relatively conventional gas-centered swirl coaxial injector element configurations such as used in Russian RD-170 and NK-33 engines, and planned for use in future U.S.-built experimental engine systems such as the Hydrocarbon Boost program demonstration engine. Four different elements were tested in both the multi-element and single-element main injectors, at similar combustion chamber pressures, chamber contraction ratios, and mixture ratios. Variations of the element features included recess depth, fuel gap width, and the presence of the sleeve separating the swirling fuel flow from the axial oxidizer flow. This paper compares the hydraulics, combustion performance, stability, and compatibility characteristics of the single-element and multi-element injectors operated at similar conditions. The single-element hardware is shown to have captured a significant level of the operability of the multi-element hardware
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A Data Driven Approach to Profile Potential SARS-CoV-2 Drug Interactions Using TylerADE
We use a data driven approach on a cleaned adverse drug reaction database to determine the reaction severity of several covid-19 drug combinations currently under investigation. We further examine their safety for vulnerable populations such as individuals 65 years and older. Our key findings include 1. hydroxychloroquine/chloroquine are associated with increased adverse drug event severity versus other drug combinations already not recommended by NIH treatment guidelines, 2. hydroxychloroquine/azithromycin are associated with lower adverse drug event severity among older populations, 3. lopinavir/ritonavir had lower adverse reaction severity among toddlers and 4. the combination of azithromycin, hydroxychloroquine and tocilizumab is safer than its component drugs. While our approach does not consider drug efficacy, it can help prioritize clinical trials for drug combinations by focusing on those with the lowest reaction severity and thus increase potential treatment options for covid-19 patients
Measurements design and phenomena discrimination
The construction of measurements suitable for discriminating signal
components produced by phenomena of different types is considered. The required
measurements should be capable of cancelling out those signal components which
are to be ignored when focusing on a phenomenon of interest. Under the
hypothesis that the subspaces hosting the signal components produced by each
phenomenon are complementary, their discrimination is accomplished by
measurements giving rise to the appropriate oblique projector operator. The
subspace onto which the operator should project is selected by nonlinear
techniques in line with adaptive pursuit strategies
Transfinite thin plate spline interpolation
Duchon's method of thin plate splines defines a polyharmonic interpolant to
scattered data values as the minimizer of a certain integral functional. For
transfinite interpolation, i.e. interpolation of continuous data prescribed on
curves or hypersurfaces, Kounchev has developed the method of polysplines,
which are piecewise polyharmonic functions of fixed smoothness across the given
hypersurfaces and satisfy some boundary conditions. Recently, Bejancu has
introduced boundary conditions of Beppo Levi type to construct a semi-cardinal
model for polyspline interpolation to data on an infinite set of parallel
hyperplanes. The present paper proves that, for periodic data on a finite set
of parallel hyperplanes, the polyspline interpolant satisfying Beppo Levi
boundary conditions is in fact a thin plate spline, i.e. it minimizes a Duchon
type functional
Self-energy limited ion transport in sub-nanometer channels
The current-voltage characteristics of the alpha-Hemolysin protein pore
during the passage of single-stranded DNA under varying ionic strength, C, are
studied experimentally. We observe strong blockage of the current, weak
super-linear growth of the current as a function of voltage, and a minimum of
the current as a function of C. These observations are interpreted as the
result of the ion electrostatic self-energy barrier originating from the large
difference in the dielectric constants of water and the lipid bilayer. The
dependence of DNA capture rate on C also agrees with our model.Comment: more experimental material is added. 4 pages, 7 figure
Achieving geodetic motion for LISA test masses: ground testing result
The low-frequency resolution of space-based gravitational wave observatories
such as LISA (Laser Interferometry Space Antenna) hinges on the orbital purity
of a free-falling reference test mass inside a satellite shield. We present
here a torsion pendulum study of the forces that will disturb an orbiting test
mass inside a LISA capacitive position sensor. The pendulum, with a measured
torque noise floor below 10 fNm/sqrt{Hz} from 0.6 to 10 mHz, has allowed
placement of an upper limit on sensor force noise contributions, measurement of
the sensor electrostatic stiffness at the 5% level, and detection and
compensation of stray DC electrostatic biases at the mV level.Comment: 4 pages (revtex4) with 4 figure
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