Interaction of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats

Patients with schizophrenia smoke cigarettes at a higher rate than the general population. We hypothesized that a factor in this comorbidity is sensitivity to the reinforcing and reinforcement- enhancement effects of nicotine. Phencyclidine (PCP) was used to model behavioral changes resembling negative symptoms of schizophrenia in rats. USVs in rats have been used to measure emotional states, with 50 kHz USVs indicating positive states and 22 kHz indicating negative. Total and categorized numbers of 22 and 50 kHz ultrasonic vocalizations (USVs) and USVs during a visual stimulus (e.g. a potential measure of reinforcement-enhancement) were examined in rats following .injection ofh PCP (2.0 mg/kg), and/or nicotine (0.2 or 0.4 mg/kg) daily for 7 days. PCP was then discontinued and all rats received nicotine (0.2 mg/kg and 0.4 mg/kg) and PCP (2.0 mg/kg) on 3 challenge days. PCP acutely decreased 50 kHz vocalizations while repeated nicotine potentiated rates of vocalizations, with similar patterns during light presentations. Rats in the PCP and nicotine combination groups made more 50 kHz vocalizations compared to control groups on challenge days. We conclude that PCP may produce a reward deficit that is shown by decreased 50 kHz USVs, and behaviors post-PCP exposure may best model the comorbidity between schizophrenia and nicotine

Dynamical Ne K Edge and Line Variations in the X-Ray Spectrum of the Ultra-compact Binary 4U 0614+091

We observed the ultra-compact binary candidate 4U 0614+091 for a total of 200 ksec with the high-energy transmission gratings onboard the \chandra X-ray Observatory. The source is found at various intensity levels with spectral variations present. X-ray luminosities vary between 2.0$\times10^{36}$ \ergsec and 3.5$\times10^{36}$ \ergsec. Continuum variations are present at all times and spectra can be well fit with a powerlaw component, a high kT blackbody component, and a broad line component near oxygen. The spectra require adjustments to the Ne K edge and in some occasions also to the Mg K edge. The Ne K edge appears variable in terms of optical depths and morphology. The edge reveals average blue- and red-shifted values implying Doppler velocities of the order of 3500 \kms. The data show that Ne K exhibits excess column densities of up to several 10$^{18}$ cm$^{-2}$. The variability proves that the excess is intrinsic to the source. The correponding disk velocities also imply an outer disk radius of the order of $< 10^9$ cm consistent with an ultra-compact binary nature. We also detect a prominent soft emission line complex near the \oviii L$\alpha$ position which appears extremely broad and relativistic effects from near the innermost disk have to be included. Gravitationally broadened line fits also provide nearly edge-on angles of inclination between 86 and 89$^{\circ}$. The emissions appear consistent with an ionized disk with ionization parameters of the order of 10$^4$ at radii of a few 10$^7$ cm. The line wavelengths with respect to \oviiia\ are found variably blue-shifted indicating more complex inner disk dynamics.Comment: 24 pages, 8 figures, submitted to the Astrophyscial Main Journa

Weakly correlated electrons on a square lattice: a renormalization group theory

We study the weakly interacting Hubbard model on the square lattice using a one-loop renormalization group approach. The transition temperature T_c between the metallic and (nearly) ordered states is found. In the parquet regime, (T_c >> |mu|), the dominant correlations at temperatures below T_c are antiferromagnetic while in the BCS regime (T_c << |mu|) at T_c the d-wave singlet pairing susceptibility is most divergent.Comment: 12 pages, REVTEX, 3 figures included, submitted to Phys. Rev. Let

On the metal-insulator transition in the two-chain model of correlated fermions

The doping-induced metal-insulator transition in two-chain systems of correlated fermions is studied using a solvable limit of the t-J model and the fact that various strong- and weak-coupling limits of the two-chain model are in the same phase, i.e. have the same low-energy properties. It is shown that the Luttinger-liquid parameter K_\rho takes the universal value unity as the insulating state (half-filling) is approached, implying dominant d-type superconducting fluctuations, independently of the interaction strength. The crossover to insulating behavior of correlations as the transition is approached is discussed.Comment: 7 pages, 1 figur

k mer

Motivation: De novo transcriptome assembly is an integral part for many RNA-seq workflows. Common applications include sequencing of non-model organisms, cancer or meta transcriptomes. Most de novo transcriptome assemblers use the de Bruijn graph (DBG) as the underlying data structure. The quality of the assemblies produced by such assemblers is highly influenced by the exact word length k. As such no single kmer value leads to optimal results. Instead, DBGs over different kmer values are built and the assemblies are merged to improve sensitivity. However, no studies have investigated thoroughly the problem of automatically learning at which kmer value to stop the assembly. Instead a suboptimal selection of kmer values is often used in practice. Results: Here we investigate the contribution of a single kmer value in a multi-kmer based assembly approach. We find that a comparative clustering of related assemblies can be used to estimate the importance of an additional kmer assembly. Using a model fit based algorithm we predict the kmer value at which no further assemblies are necessary. Our approach is tested with different de novo assemblers for datasets with different coverage values and read lengths. Further, we suggest a simple post processing step that significantly improves the quality of multi-kmer assemblies. Conclusion: We provide an automatic method for limiting the number of kmer values without a significant loss in assembly quality but with savings in assembly time. This is a step forward to making multi-kmer methods more reliable and easier to use. Availability and Implementation:A general implementation of our approach can be found under: https://github.com/SchulzLab/KREATION. Supplementary information: Supplementary data are available at Bioinformatics online. Contact: [email protected]

A possible phase diagram of a t-J ladder model

We investigate a t-J ladder model by numerical diagonalization method. By calculating correlation functions and assuming the Luttinger liquid relation, we obtained a possible phase diagram of the ground state as a function of J/t and electron density $n$. We also found that behavior of correlation functions seems to consist with the prediction of Luttinger liquid relation. The result suggests that the superconducting phase appear in the region of $J/t \displaystyle{ \mathop{>}_{\sim}} 0.5$ for high electron density and $J/t \displaystyle{ \mathop{>}_{\sim}} 2.0$ for low electron density.Comment: Latex, 10 pages, figures available upon reques